{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:38:44Z","timestamp":1787071124206,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>Acute-onset ophthalmoplegia is a perplexing diagnosis in a young child. When the full-blown picture of ophthalmoplegia, ataxia, and areflexia is evident, the diagnosis of Miller\u2013Fisher syndrome (MFS), a variant of Guillain\u2013Barre syndrome (GBS), is almost certain. However, the same is not true for isolated external ophthalmoplegia as it is etiologically heterogeneous. Only anecdotal case reports of childhood-onset acute ophthalmoplegia exist in the literature. Adult series suggest that acute onset external ophthalmoplegia is often immune-mediated and is secondary to anti-GQ1b antibodies. We present a 30-month-old boy with acute-onset bilateral external ophthalmoplegia with highly elevated serum anti-GQ1b antibodies. The child had a rapid and complete recovery with intravenous immunoglobulin. A review of all published cases of childhood anti-GQ1b antibody syndrome was performed. The case highlights that anti-GQ1b antibody syndrome should be considered even in young children with acute-onset external ophthalmoplegia. The disease has a favorable prognosis. The majority improve on conservative management. Treatment with steroids or IVIG may be considered in some after weighing the risks and benefits.<\/jats:p>","DOI":"10.4103\/0028-3886.359274","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T03:31:06Z","timestamp":1667273466000},"page":"2159-2162","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Acute Isolated External Ophthalmoplegia: Think of Anti-GQ1b Antibody Syndrome"],"prefix":"10.4103","volume":"70","author":[{"given":"Sachendra","family":"Badal","sequence":"first","affiliation":[{"name":"Centre of Excellence and Advanced Research on Childhood Neurodevelopmental Disorders, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Jauhari","sequence":"additional","affiliation":[{"name":"Centre of Excellence and Advanced Research on Childhood Neurodevelopmental Disorders, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Singh","sequence":"additional","affiliation":[{"name":"Centre of Excellence and Advanced Research on Childhood Neurodevelopmental Disorders, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Kamilla","sequence":"additional","affiliation":[{"name":"Centre of Excellence and Advanced Research on Childhood Neurodevelopmental Disorders, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswaroop","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Centre of Excellence and Advanced Research on Childhood Neurodevelopmental Disorders, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheffali","family":"Gulati","sequence":"additional","affiliation":[{"name":"Centre of Excellence and Advanced Research on Childhood Neurodevelopmental Disorders, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"R1-20250926","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1055\/s-0033-1334470","article-title":"Miller Fisher's syndrome","volume":"32","author":"Teener","year":"2013","journal-title":"Semin Neurol"},{"key":"R2-20250926","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1212\/01.wnl.0000324266.95814.74","article-title":"Acute ophthalmoplegia (without ataxia) associated with anti-GQ1b 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