{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:27:38Z","timestamp":1792682858610,"version":"4.5.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The standard recommended and common reconstruction method for spinal tuberculosis is titanium mesh bone graft and autogenous iliac crest. However, these methods have their own disadvantages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy of one-stage posterior debridement with iliac bone graft, titanium mesh bone graft, or nanohydroxyapatite\/polyamide-66 cage in thoracic and lumbar tuberculosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Between January 2013 and December 2018, 57 patients with thoracic or lumbar tuberculosis were treated by interbody bone graft combined with posterior internal fixation after debridement. Thirteen patients were treated with iliac bone graft to construct the stability of the vertebral body, 26 patients were treated with titanium mesh bone graft, and 18 patients were treated with nanohydroxyapatite\/polyamide-66 cage bone graft. The main clinical results were evaluated by intervertebral height, cage subsidence, operation time, operative blood loss, postoperative hospitalization, postoperative complications, visual analog scale (VAS) score, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), American Spinal Injury Association (ASIA) grade, and bone graft fusion time. All the outcomes were recorded and analyzed by statistical methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean follow-up time was 24.5 months. Neurologic function was improved in most patients at the last follow-up. There were significant differences in ESR, CRP, and VAS score between preoperative and postoperative values; however, there were no significant differences in ESR, CRP, and VAS score among the three groups. There were no significant differences in operation time, blood loss, postoperative hospitalization, and postoperative complications among the three groups at discharge. There was no significant difference in ASIA grade among the three groups at the last follow-up. Nanohydroxyapatite\/polyamide-66 cage group had a lower cage subsidence (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.013). The bone graft fusion time of the nanohydroxyapatite\/polyamide-66 cage group was significantly shorter than the iliac bone graft group and the titanium mesh bone graft (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The follow-up outcomes showed that the method involving one-stage posterior debridement and internal fixation, interbody graft, and fusion is an effective and safe surgical method for patients with thoracic and lumbar tuberculosis. The incidence rate of cage subsidence was less and the bone graft fusion time was shorter with nanohydroxyap atite\/polyamide 66 cage when compared with iliac bone graft and titanium mesh bone graft in the surgical treatment of thoracic and lumbar tuberculosis. Nanohydroxyapatite\/polyamide-66 cage has a promising application prospect to be a new bone graft material.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.360908","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:28:48Z","timestamp":1692847728000},"page":"S230-S238","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of Nanohydroxyapatite\/Polyamide-66 Cage, Titanium Mesh, and Iliac Crest in Spinal Reconstruction of the Patients with Thoracic and Lumbar Tuberculosis"],"prefix":"10.4103","volume":"70","author":[{"given":"Dian","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yong","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-22-20240907","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1302\/0301-620X.92B7.24668","article-title":"Tuberculosis of the spine: A fresh look at an old disease","volume":"92","author":"Jain","year":"2010","journal-title":"J Bone Joint Surg Br"},{"key":"R2-22-20240907","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2106\/JBJS.19.00001","article-title":"Tuberculosis of the Spine","volume":"102","author":"Jain","year":"2020","journal-title":"J Bone Joint Surg Am"},{"key":"R3-22-20240907","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1302\/0301-620X.100B4.BJJ-2017-1040.R1","article-title":"Spinal tuberculosis: Review of current management","volume":"100B","author":"Dunn","year":"2018","journal-title":"Bone Joint J"},{"key":"R4-22-20240907","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s11596-016-1622-7","article-title":"One-stage surgical treatment for thoracic and lumbar Spinal tuberculosis by transpedicular fixation, debridement, and combined interbody and posterior fusion via a posterior-only approach","volume":"36","author":"Ran","year":"2016","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"R5-22-20240907","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1007\/s00586-016-4516-2","article-title":"Anterior versus posterior debridement fusion for single-level dorsal tuberculosis: The role of graft-type and level of fixation on determining the outcome","volume":"25","author":"Assaghir","year":"2016","journal-title":"Eur Spine J"},{"key":"R6-22-20240907","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00264-011-1469-2","article-title":"Kyphotic deformity in spinal tuberculosis and its management","volume":"36","author":"Rajasekaran","year":"2012","journal-title":"Int Orthop"},{"key":"R7-22-20240907","doi-asserted-by":"crossref","first-page":"e12471","DOI":"10.1097\/MD.0000000000012471","article-title":"The reasons and clinical treatments of postoperative relapse of Pott's disease","volume":"97","author":"Yin","year":"2018","journal-title":"Medicine (Baltimore"},{"key":"R8-22-20240907","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijsu.2020.05.039","article-title":"Comparison of three different bone graft methods for single segment lumbar tuberculosis: A retrospective single-center cohort study","volume":"79","author":"Du","year":"2020","journal-title":"Int J Surg"},{"key":"R9-22-20240907","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2484\/rcr.v1i1.9","article-title":"Postoperative bone graft displacement: An unusual sign of infection following posterior spinal fusion","volume":"1","author":"Myhre","year":"2015","journal-title":"Radiol Case Rep"},{"key":"R10-22-20240907","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1302\/0301-620X.85B7.13398","article-title":"Cage versus tricortical graft for cervical interbody fusion. 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