{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:31:09Z","timestamp":1786728669757,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"\n Background:<\/jats:title>\n There is scant literature comparing high tidal volume ventilation (HTV) over low tidal volume (LTV) ventilation in acute traumatic cervical spinal cord injury (CSCI).<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n \n The aim of this prospective randomized controlled parallel-group, single-blinded study was to compare the effect of two different tidal volumes (12\u201315 mL\/kg and 6\u20138 mL\/kg) in CSCI on days to achieve ventilator-free breathing (VFB), PaO\n 2<\/jats:sub>\n \/FIO\n 2<\/jats:sub>\n ratio, the incidence of complications, requirement of vasopressor drugs, total duration of hospital stay, and mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n We enrolled patients with acute high traumatic CSCI admitted to the neurotrauma intensive care unit within 24 h of injury, requiring mechanical ventilation. Participants were randomized to receive either HTV, 12\u201315 mL\/kg (group H) or LTV, 6\u20138 mL\/kg (group L) tidal volume ventilation.<\/jats:p>\n <\/jats:sec>\n \n Results and Conclusions:<\/jats:title>\n \n A total of 56 patients, 28 in each group were analyzed. Patient demographics and injury severity were comparable between the groups. VFB was achieved in 23 and 19 patients in groups H and L, respectively. The median number of days required to achieve VFB was 3 (2, 56) and 8 (2, 50) days,\n P<\/jats:italic>\n = 0.33; PaO\n 2<\/jats:sub>\n : FIO\n 2<\/jats:sub>\n ratio was 364.0 \u00b1 64 and 321.0 \u00b1 67.0,\n P<\/jats:italic>\n = 0.01; the incidence of atelectasis was 25% and 46%,\n P<\/jats:italic>\n = 0.16, respectively, in group H and group L. The hemodynamic parameters and the vasopressor requirement were comparable in both groups. There was no barotrauma. The duration of hospital stay (\n P<\/jats:italic>\n = 0.2) and mortality (\n P<\/jats:italic>\n = 0.2) was comparable in both groups. There was no significant difference in days to achieve ventilator-free breathing with HTV (12\u201315 mL\/kg) ventilation compared to LTV (6\u20138 mL\/kg) ventilation in acute CSCI. The PaO\n 2<\/jats:sub>\n :FiO\n 2<\/jats:sub>\n ratio was higher with the use of 12\u201315 mL\/kg. No difference in mortality and duration of hospital stay was seen in either group.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0028-3886.360926","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:28:48Z","timestamp":1692847728000},"page":"S282-S287","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Different Tidal Volumes for Ventilation in Patients with an Acute Traumatic Cervical Spine Injury"],"prefix":"10.4103","volume":"70","author":[{"given":"Deep","family":"Sengupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Bindra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purva","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maroof A","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-30-20240907","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/10790268.2007.11753946","article-title":"Respiratory management during the first five days after spinal cord injury","volume":"30","author":"Berlly","year":"2007","journal-title":"J Spinal Cord Med"},{"key":"R3-30-20240907","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1310\/sci1804-283","article-title":"Specialized respiratory management for acute cervical spinal cord injury: A retrospective analysis","volume":"18","author":"Wong","year":"2012","journal-title":"Top Spinal Cord Inj Rehabil"},{"key":"R4-30-20240907","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1056\/NEJMoa1301082","article-title":"A trial of intraoperative low-tidal-volume ventilation in abdominal surgery","volume":"369","author":"Futier","year":"2013","journal-title":"N Engl J Med"},{"key":"R5-30-20240907","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/sj.sc.3100818","article-title":"The effect of tidal volumes on the time to wean persons with high tetraplegia from ventilators","volume":"37","author":"Peterson","year":"1999","journal-title":"Spinal Cord"},{"key":"R6-30-20240907","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/sc.2015.145","article-title":"A comparison of high vs standard tidal volumes in ventilator weaning for individuals with sub-acute spinal cord injuries: A site-specific randomized clinical trial","volume":"54","author":"Fenton","year":"2016","journal-title":"Spinal Cord"},{"key":"R7-30-20240907","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome","volume":"342","author":"Brower","year":"2000","journal-title":"N Engl J Med"},{"key":"R8-30-20240907","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1001\/jama.2018.14280","article-title":"Effect of a low vs intermediate tidal volume strategy on ventilator-free days in intensive care unit patients without ARDS: A randomized clinical trial","volume":"320","author":"Simonis","year":"2018","journal-title":"JAMA"},{"key":"R9-30-20240907","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.anclin.2018.09.009","article-title":"Advanced Trauma Life Support\u00ae Update 2019: Management and applications for adults and special populations","volume":"37","author":"Galvagno","year":"2019","journal-title":"Anesthesiol Clin"},{"key":"R11-30-20240907","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15761\/JCIS.1000105","article-title":"Validation of the Broca index as the most practical method to calculate the ideal body weight","volume":"1","author":"Alejandro","year":"2018","journal-title":"J Clin Investig Stud"},{"key":"R12-30-20240907","doi-asserted-by":"crossref","first-page":"665","DOI":"10.4103\/0972-5229.169342","article-title":"Height measurement in the critically ill patient: A tall order in the critical care unit","volume":"19","author":"Venkataraman","year":"2015","journal-title":"Indian J Crit Care Med"},{"key":"R13-30-20240907","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/bjaceaccp\/mkn005","article-title":"Sedation in the intensive care unit","volume":"8","author":"Rowe","year":"2008","journal-title":"Contin Educ Anaesthesia, Crit Care Pain"},{"key":"R14-30-20240907","first-page":"365","article-title":"The new Berlin definition: What is, finally, the ards?","volume":"25","author":"Pneumatikos","year":"2012","journal-title":"Pneumon"},{"key":"R15-30-20240907","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00005382-199621000-00003","article-title":"Radiographic manifestations of lobar atelectasis","volume":"11","author":"Woodring","year":"1996","journal-title":"J Thorac Imaging"},{"key":"R17-30-20240907","first-page":"S38","article-title":"Barotrauma and pneumothorax","volume":"7","author":"Ioannidis","year":"2015","journal-title":"J Thorac Dis"},{"key":"R18-30-20240907","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41393-017-0055-x","article-title":"Discontinuous ventilator weaning of patients with acute SCI","volume":"56","author":"F\u00fcssenich","year":"2018","journal-title":"Spinal Cord"},{"key":"R19-30-20240907","doi-asserted-by":"crossref","first-page":"168757","DOI":"10.1155\/2013\/168757","article-title":"Respiratory management in the patient with spinal cord injury","volume":"2013","author":"Galeiras V\u00e1zquez","year":"2013","journal-title":"Biomed Res Int"},{"key":"R20-30-20240907","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/0888439003251751","article-title":"Respiratory management of pediatric patients with spinal cord injuries: Retrospective review of the duPont experience","volume":"17","author":"Padman","year":"2003","journal-title":"Neurorehabil Neural Repair"},{"key":"R21-30-20240907","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/sc.2017.10","article-title":"Pulmonary outcomes following specialized respiratory management for acute cervical spinal cord injury: A retrospective analysis","volume":"55","author":"Zakrasek","year":"2017","journal-title":"Spinal Cord"},{"key":"R22-30-20240907","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1080\/10790268.2020.1722936","article-title":"High tidal volume ventilation is associated with ventilator-associated pneumonia in acute cervical spinal cord injury","volume":"44","author":"Hatton","year":"2021","journal-title":"J Spinal Cord Med"},{"key":"R23-30-20240907","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/TA.0b013e318251fb34","article-title":"Predicting the need for tracheostomy in patients with cervical spinal cord injury","volume":"73","author":"Leelapattana","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"key":"R24-30-20240907","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1310\/K4Y4-YDXQ-9VNY-F562","article-title":"Acute ventilator management and weaning in individuals with high tetraplegia","volume":"10","author":"Wallbom","year":"2005","journal-title":"Top Spinal Cord Inj Rehabil"},{"key":"R25-30-20240907","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/bja\/71.6.788","article-title":"Re-expansion of atelectasis during general anaesthesia: A computed tomography study","volume":"71","author":"Rothen","year":"1993","journal-title":"Br J Anaesth"},{"key":"R26-30-20240907","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/sc.2010.39","article-title":"The acute respiratory management of cervical spinal cord injury in the first 6 weeks after injury: A systematic review","volume":"49","author":"Berney","year":"2011","journal-title":"Spinal Cord"},{"key":"R27-30-20240907","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41393-018-0196-6","article-title":"Early clinical predictors of pneumonia in critically ill spinal cord injured individuals: A retrospective cohort study","volume":"57","author":"Agostinello","year":"2019","journal-title":"Spinal Cord"},{"key":"R28-30-20240907","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41393-019-0286-0","article-title":"Risk indicators of length of acute hospital stay after traumatic spinal cord injury in South Africa: A prospective, population-based study","volume":"57","author":"Conradsson","year":"2019","journal-title":"Spinal Cord"},{"key":"R29-30-20240907","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1179\/2045772314Y.0000000254","article-title":"Airway complications in traumatic lower cervical spinal cord injury: A retrospective study","volume":"38","author":"Liebscher","year":"2015","journal-title":"J Spinal Cord Med"},{"key":"R30-30-20240907","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s41393-020-0421-y","article-title":"Italian SCI Study Group. Traumatic spinal cord injury in Italy 20 years later: Current epidemiological trend and early predictors of rehabilitation outcome","volume":"58","author":"Franceschini","year":"2020","journal-title":"Spinal Cord"},{"key":"R31-30-20240907","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41394-021-00459-6","article-title":"An investigation of the prolonged requirement (>7 days) of vasopressors in cervical spinal cord injury patients-a retrospective analysis","volume":"7","author":"Mishra","year":"2","journal-title":"Spinal Cord Ser Cases 2021 N"},{"key":"R32-30-20240907","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000382079","article-title":"Mortality and longevity after a spinal cord injury: Systematic review and meta-analysis","volume":"44","author":"Chamberlain","year":"2015","journal-title":"Neuroepidemiology"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.360926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:30:12Z","timestamp":1786725012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.360926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":29,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.360926","relation":{},"ISSN":["0028-3886"],"issn-type":[{"value":"0028-3886","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}