{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:19:21Z","timestamp":1787761161163,"version":"build-2784847793"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      The association between exposure to\n                      <jats:italic toggle=\"yes\">Toxocara canis<\/jats:italic>\n                      and epilepsy is at the best contentious. Most of previous studies were retrospective, community-based, and contradictory to one another. As the impact of a positive association on the magnitude of epilepsy will be huge especially in developing countries where toxocariasis is common owing to poor hygienic practices, this study was carried out to determine whether exposure to\n                      <jats:italic toggle=\"yes\">T. canis<\/jats:italic>\n                      predisposes to development of epilepsy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>\n                      This case-controlled observational study was carried out a tertiary healthcare center in North India on 120 patients with newly diagnosed epilepsy who presented within 3 months of diagnosis. A total of 120 age- and sex-matched individuals from the same community were chosen as controls. Epilepsy was defined according to ILAE 1993 definition. Serological testing for\n                      <jats:italic toggle=\"yes\">T. canis<\/jats:italic>\n                      was carried out using commercially available ELISA kits. All the positive samples were subjected to Western blot testing for confirmation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The prevalence of antibodies to\n                      <jats:italic toggle=\"yes\">T. canis<\/jats:italic>\n                      was similar in cases (16\/120; 13.3%) and controls (16\/120; 13.3%). Among the various risk factors, history of pica was significantly associated with\n                      <jats:italic toggle=\"yes\">T. canis<\/jats:italic>\n                      seropositivity, while lack of hand washing was significantly associated with higher risk of epilepsy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Our study could not find any association between exposure to\n                      <jats:italic toggle=\"yes\">T. canis<\/jats:italic>\n                      and epilepsy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.364076","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T11:28:36Z","timestamp":1671190116000},"page":"2383-2387","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Exposure to Toxocara Canis is not Associated with New-Onset Epilepsy"],"prefix":"10.4103","volume":"70","author":[{"given":"Vivek","family":"Rishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajveer","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Kumar","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Modi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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