{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:55:28Z","timestamp":1787972128933,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Wilson's disease is a genetic disorder characterized by abnormal accumulation of copper in the brain, liver, eye, and kidney. Various neuropsychiatric manifestations such as dystonia, parkinsonism, choreoathetosis, tremor, ataxia, personality disorders, mood changes, psychosis, cognitive abnormalities, sleep disorders, dystonia, tremor, ataxia, and seizures are known to occur in Wilson's disease. Status epilepticus is a very rare presentation of this disease. Here, we present a case of Wilson's disease occurring in an adolescent, who presented with refractory convulsive status epilepticus. His magnetic resonance imaging of the brain showed bilateral external capsular hyper intensities, with only subtle changes in other brain areas and the only clue to the presence of Wilson's disease was the presence of mildly deranged hepatic enzymes. The 24-h-urinary copper levels were subsequently found to be elevated in this patient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.364078","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T11:28:36Z","timestamp":1671190116000},"page":"2446-2448","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["External Capsular Hyperintensities in Wilson's Disease Presenting with Refractory Status Epilepticus"],"prefix":"10.4103","volume":"70","author":[{"given":"Tandon","family":"Ruchika","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mittal","family":"Madhukar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goyal K","family":"Abhishek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-23-20240907","doi-asserted-by":"crossref","first-page":"15","DOI":"10.5152\/TurkPediatriArs.2016.3080","article-title":"Neurological features and management of Wilson disease in children: An evaluation of 12 cases","volume":"51","author":"Bayram","year":"2016","journal-title":"Turk Pediatri Ars"},{"key":"R2-23-20240907","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/bs.irn.2017.04.010","article-title":"Non motor manifestations of Wilson's disease","volume":"134","author":"Biswas","year":"2017","journal-title":"Int Rev Neurobiol"},{"key":"R3-23-20240907","first-page":"1372","article-title":"MR imaging of heat stroke: External capsule and thalamic T1 shortening and cerebellar injury","volume":"24","author":"Mc Laughlin","year":"2003","journal-title":"Am J 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giant panda and her cub: MRI correlates of Wilson's disease","volume":"74","author":"Liebeskind","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R8-23-20240907","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jns.2012.09.013","article-title":"Characteristics of neurological Wilson's disease without Kayser-Fleischer ring","volume":"323","author":"Youn","year":"2012","journal-title":"J Neurol Sci"},{"key":"R9-23-20240907","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1212\/WNL.46.4.1040","article-title":"Neurologic presentation of Wilson disease without Kayser-Fleischer rings","volume":"46","author":"Demirkiran","year":"1996","journal-title":"Neurology"},{"key":"R10-23-20240907","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.seizure.2010.07.018","article-title":"Partial status epilepticus induced by hypocupremia in a patient with Wilson's disease","volume":"19","author":"Benbir","year":"2010","journal-title":"Seizure"},{"key":"R11-23-20240907","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1684\/epd.2009.0254","article-title":"Status epilepticus in Wilson's disease","volume":"11","author":"Pestana Knight","year":"2009","journal-title":"Epileptic Disord"},{"key":"R12-23-20240907","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jns.2010.01.007","article-title":"Spectrum of epilepsy in Wilson's disease with electroencephalographic, MR imaging and pathological correlates","volume":"291","author":"Prashanth","year":"2010","journal-title":"J Neurol Sci"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.364078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:25:10Z","timestamp":1787757910000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.364078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.364078","relation":{},"ISSN":["0028-3886"],"issn-type":[{"value":"0028-3886","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}