{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:19:11Z","timestamp":1787840351410,"version":"build-2784847793"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Parinaud syndrome is a dorsal mid-brain syndrome characterized by upgaze paralysis, convergence retraction nystagmus, and pupillary light-near dissociation. Infarctions or hemorrhages involving the mid-brain are the most frequent causes in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To report a novel case of a patient who presented with classical parkinsonian signs and Parinaud syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>Patient data were obtained from medical records from the Department of General Medicine, Burdwan Medical College and Hospital, Burdwan, West Bengal, India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A 62-year-old previously healthy man presented with motor and non-motor symptoms of Parkinson's disease (PD) for the past 6 years. The neurological examination revealed an asymmetric resting tremor of the upper limbs with rigidity, bradykinesia, hypophonia, hypomimia, decreased blinking, and micrographia. The neuro-ophthalmological examination showed Parinaud syndrome. He was treated with levodopa-carbidopa and trihexyphenidyl. After 6 months and 1 year of follow-up, his neurological condition was re-assessed; motor symptoms improved substantially, but Parinaud syndrome persisted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Parinaud syndrome can be a potential manifestation of PD. A detailed neuro-ophthamological examination should be carried out even in patients having a diagnosis of classic PD in whom eye-movement abnormalities are distinctly infrequent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.370439","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:06:41Z","timestamp":1692850001000},"page":"129-131","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Parinaud Syndrome in a Patient with Parkinson's Disease: Causal Association or Co-incidental?"],"prefix":"10.4103","volume":"71","author":[{"given":"Souvik","family":"Dubey","sequence":"first","affiliation":[{"name":"Department of Neuromedicine, Bangur Institute of Neurosciences, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritwik","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Burdwan Medical College & Hospital, Burdwan, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biman Kanti","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine, Bangur Institute of Neurosciences, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Guti\u00e9rrez-Ortiz","sequence":"additional","affiliation":[{"name":"Department of Glaucoma and Neuro-Ophthalmology, University Hospital \u201cPr\u00edncipe de Asturias\u201d, Alcal\u00e1 de Henares;"},{"name":"Department of Glaucoma, \u201dMart\u00ednez de Carneros\u201d Clinic, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Benito-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital \u201c12 de Octubre\u201d"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED)"},{"name":"Department of Medicine, Complutense University, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"R1-20250613","doi-asserted-by":"crossref","first-page":"e792","DOI":"10.1111\/aos.13283","article-title":"Parinaud syndrome: A 25-year (1991-2016) review of 40 consecutive adult cases","volume":"95","author":"Shields","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"R2-20250613","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3389\/fneur.2017.00429","article-title":"Clinical approach to supranuclear brainstem saccadic gaze palsies","volume":"8","author":"Lloyd-Smith Sequeira","year":"2017","journal-title":"Front Neurol"},{"key":"R3-20250613","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/mds.10362","article-title":"Prevalence of PD and other types of parkinsonism in three elderly populations of central Spain","volume":"18","author":"Benito-Le\u00f3n","year":"2003","journal-title":"Mov Disord"},{"key":"R5-20250613","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1093\/brain\/122.9.1637","article-title":"Frontal, midbrain, and striatal dopaminergic function in early and advanced Parkinson's disease A 3D [(18) F] dopa-PET study","volume":"122","author":"Rakshi","year":"1999","journal-title":"Brain"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.370439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:21:09Z","timestamp":1787836869000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.370439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.370439","relation":{},"ISSN":["0028-3886","1998-4022"],"issn-type":[{"value":"0028-3886","type":"print"},{"value":"1998-4022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2022-01-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}