{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:19:12Z","timestamp":1787840352714,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Fibrin glue as an adjunct in peripheral nerve injuries has gained recent popularity. Whether fibrosis and inflammatory processes which are the major hindrances in repair reduce with fibrin glue has more of theoretical support than experimental.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>A prospective nerve repair study was conducted between two different species of rats as donor and recipient. Four comparison groups with 40 rats were outlined with or without fibrin glue in immediate post-injury period with fresh or cold preserved grafts were examined based on histological, macroscopic, functional, and electrophysiological criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There was suture site granuloma along with neuroma formation and inflammatory reaction and severe epineural inflammation in allografts with immediate suturing (Group A), whereas suture site inflammation and epineural inflammation were negligible in cold preserved allografts with immediate suturing (Group B). Allografts with minimal suturing and glue (Group C) had less severe epineural inflammation with less severe suture site granuloma and neuroma formation as compared to first two groups. Continuity of nerve was partial in later group as compared to other two. In fibrin glue only group (Group D), suture site granuloma and neuroma were absent, with negligible epineural inflammation, but continuity nerve was partial to absent in most of the rats with some showing partial continuity. Functionally, microsuturing with or without glue demonstrated significant difference with better SLR and toe spread (p = 0.042) as compared with only glue. Electrophysiologically, NCV was maximum in Group A and least in Group D at 12 weeks. We report significant difference in CMAP and NCV between microsuturing group vs. only glue group (p &lt; 0.05) and also between microsuturing with glue group vs. only glue group (p &lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There may be more data required with proper standardization for adept usage of fibrin glue. Though our results have shown partial success, it nonetheless highlights the lack of sufficient data for widespread glue usage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.370473","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:06:41Z","timestamp":1692850001000},"page":"55-61","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Is Popularity of Fibrin Glue a Misrepresentation? A Comparative Study with Fibrin Glue and Suture Anastomosis in Rat Sciatic Nerve Injury Analysing Functional, Histological, Electrophysiological Parameters"],"prefix":"10.4103","volume":"71","author":[{"given":"Hardik L","family":"Siroya","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, AIIMS, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod B","family":"Kumar","sequence":"additional","affiliation":[{"name":"Consultant Neurosurgeon, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjaya I","family":"Bhat","sequence":"additional","affiliation":[{"name":"Consultant Neurosurgeon, ASTER Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaval P","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences, NIMHANS, Hosur Road, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagavatula I","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences, NIMHANS, Hosur Road, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"R2-20250613","first-page":"Doc14","article-title":"Fibrin glue as a protective tool for microanastomoses in limb reconstructive surgery","volume":"4","author":"Langer","year":"2015","journal-title":"GMS Interdiscip Plast Reconstr Surg DGPW"},{"key":"R3-20250613","first-page":"44","article-title":"Comparison of the never repair with fibrin glue and perineural micro-suture in rat model","volume":"9","author":"Akbari","year":"2020","journal-title":"World J Plast Surg"},{"key":"R5-20250613","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.4103\/1673-5374.156992","article-title":"Fibrin glue repair leads to enhanced axonal elongation during early peripheral nerve regeneration in an in vivo mouse model","volume":"10","author":"Koulaxouzidis","year":"2015","journal-title":"Neural Regen Res"},{"key":"R6-20250613","doi-asserted-by":"crossref","first-page":"21637","DOI":"10.1038\/s41598-020-78481-1","article-title":"A novel nerve transection and repair method in mice: Histomorphometric analysis of nerves, blood vessels, and muscles with functional recovery","volume":"10","author":"Lee","year":"2020","journal-title":"Sci Rep"},{"key":"R7-20250613","first-page":"65","article-title":"Suture versus fibrin glue microneural anastomosis of the femoral nerve in sprague dewly rat model. 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