{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:30:53Z","timestamp":1786728653375,"version":"build-2736575974"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the difference in mean serum 25-hydroxy vitamin D level between migraineurs and nonmigraineurs, the association between hypovitaminosis D and migraine, and the effects of oral vitamin D supplementation on migraine-related symptoms as compared to placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Relevant databases were searched for observational studies and randomized-controlled trials (RCTs) which evaluated the difference in mean serum 25-hydroxy vitamin D level between migraineurs and nonmigraineurs; the association between hypovitaminosis D and migraine; and the effects of vitamin D supplementation on migraine-frequency, duration, and severity. Pooled mean difference and odds ratio were calculated (random-effects model, RevMan version 5.3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Ten observational studies and two RCTs were included. The serum 25-hydroxy vitamin D level in the migraineurs was significantly lower than that in the nonmigraineurs [mean difference \u2212 4.44 ng\/mL (95% CI: \u22126.11, \u22122.77)] (low-GRADE evidence). Hypovitaminosis D was found to be significantly associated with migraine [OR: 1.95 (95% CI: 1.07, 3.58)] (low-GRADE evidence). As compared to placebo, oral vitamin D supplementation significantly reduced the monthly migraine-frequency [mean difference: \u22122.20 (95% CI: \u22123.04, \u22121.36)]<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>,<\/jats:title>\n                    <jats:p>although it did not reduce the migraine-duration [mean difference: \u221216.00 hours per month (95% CI: \u221242.77, 10.76)] and migraine-severity score [standardized mean difference: \u22120.23 (95% CI: \u22120.79, 0.32)] (moderate-GRADE evidence).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Serum 25-hydroxy vitamin D level was significantly lower in the migraineurs than that in the nonmigraineurs, and hypovitaminosis D was significantly associated with migraine. Oral vitamin D supplementation significantly reduced migraine-frequency, but not its duration and severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.383862","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:21:33Z","timestamp":1692850893000},"page":"655-661","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Vitamin D on Migraine"],"prefix":"10.4103","volume":"71","author":[{"given":"Saibal","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayan","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapan Kumar","family":"Behera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhiya","family":"Selvarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadishkumar","family":"Kamalanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya Prakash","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N Sreekumaran","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20240907","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.npep.2013.10.010","article-title":"CGRP and migraine: Could PACAP play a role too?","volume":"47","author":"Kaiser","year":"2013","journal-title":"Neuropeptides"},{"key":"R2-4-20240907","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1212\/WNL.0b013e3181c777d5","article-title":"Vascular smooth muscle cell dysfunction in patients with migraine","volume":"74","author":"Devor","year":"2010","journal-title":"Neurology"},{"key":"R3-4-20240907","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neurol.2015.11.005","article-title":"Vitamin D deficiency and its role in neurological conditions: A review","volume":"172","author":"Mpandzou","year":"2016","journal-title":"Rev Neurol (Paris"},{"key":"R4-4-20240907","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchemneu.2010.10.001","article-title":"Vitamin D receptor and enzyme expression in dorsal root ganglia of adult female rats: Modulation by Ovarian Hormones","volume":"41","author":"Tague","year":"2011","journal-title":"J Chem Neuroanat"},{"key":"R5-4-20240907","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jchemneu.2004.08.006","article-title":"Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain","volume":"29","author":"Eyles","year":"2005","journal-title":"J Chem Neuroanat"},{"key":"R6-4-20240907","doi-asserted-by":"crossref","first-page":"1273574","DOI":"10.1080\/16546628.2016.1273574","article-title":"The impact of vitamin D supplement intake on vascular endothelial function; a systematic review and meta-analysis of randomized controlled trials","volume":"61","author":"Mazidi","year":"2017","journal-title":"Food Nutr Res"},{"key":"R9-4-20240907","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"R10-4-20240907","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jclinepi.2012.03.013","article-title":"GRADE guidelines: 14. 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