{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:05:32Z","timestamp":1790867132931,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Mycobacterium abscessus<\/jats:italic>\n                      complex (MabC) has emerged as an important cause of human infections, including meningitis. In the absence of correct microbiological identification, cases of MabC meningitis are treated with conventional anti-tubercular therapy, thereby worsening the outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The current study was conducted to determine the clinical features, antimicrobial susceptibility, and outcome of patients with MabC meningitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>Cerebrospinal fluid specimens processed between 2011 and 2021 were subjected to smear, culture, MALDI TOF identification, hsp65 gene sequencing, and susceptibility testing using Sensititre\u2122 RAPMYCOI plates along with a literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      12 cases of MabC meningitis were identified between 2011 and 2021, 11 of which were\n                      <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                      subspecies\n                      <jats:italic toggle=\"yes\">abscessus<\/jats:italic>\n                      on hsp65 gene sequencing. A pioneer case of meningitis with\n                      <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                      subspecies\n                      <jats:italic toggle=\"yes\">bolletii<\/jats:italic>\n                      was also identified. The common predispositions were TB elsewhere, HIV positivity, and head injury. Two patients had dual infections, both MabC and TB. Ten patients succumbed to infection with a mean survival of 11 months. All isolates were susceptible to amikacin and tigecycline and subspecies\n                      <jats:italic toggle=\"yes\">bolletii<\/jats:italic>\n                      had a higher minimum inhibitory concentration (MIC) than subspecies\n                      <jats:italic toggle=\"yes\">abscessus<\/jats:italic>\n                      . A combined analysis with the available literature, reporting 19 more cases, revealed that the overall mortality of MabC meningitis was 61.3% (19\/31) and that of shunt-associated\/neurosurgical intervention-related MabC meningitis was 66.7% (12\/20). To date, out of 20 MabC meningitis isolates in which subspecies identification was carried, 13 were\n                      <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                      , six were\n                      <jats:italic toggle=\"yes\">M<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">massiliense<\/jats:italic>\n                      , and one was\n                      <jats:italic toggle=\"yes\">M. bolletii<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MabC is an important differential diagnosis of chronic meningitis. Prompt identification and speciation are imperative for targeted therapy, thus improving the overall patient outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.388095","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:01:15Z","timestamp":1697612475000},"page":"946-952","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Mycobacterium abscessus Complex-Associated Chronic Meningitis"],"prefix":"10.4103","volume":"71","author":[{"given":"Kusum","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Shree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallab","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apinderpreet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Modi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20240907","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41579-020-0331-1","article-title":"Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus","volume":"18","author":"Johansen","year":"2020","journal-title":"Nat Rev Microbiol"},{"key":"R2-15-20240907","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/jac\/dkr578","article-title":"Mycobacterium abscessus: A new antibiotic nightmare","volume":"67","author":"Nessar","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"R3-15-20240907","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/microorganisms7030090","article-title":"Mycobacterium abscessus: Environmental bacterium turned clinical nightmare","volume":"7","author":"Lopeman","year":"2019","journal-title":"Microorganisms"},{"key":"R4-15-20240907","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.5588\/ijtld.14.0120","article-title":"The epidemiologic relationship between tuberculosis and nontuberculous mycobacterial disease: A systematic review","volume":"18","author":"Brode","year":"2014","journal-title":"Int J Tuberc Lung Dis"},{"key":"R5-15-20240907","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.3390\/jcm9082541","article-title":"General overview of nontuberculous mycobacteria opportunistic pathogens: Mycobacterium avium and Mycobacterium abscessus","volume":"9","author":"To","year":"2020","journal-title":"J Clin Med"},{"key":"R6-15-20240907","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/jac\/dkr420","article-title":"CNS infections caused by Mycobacterium abscessus complex: Clinical features and antimicrobial susceptibilities of isolates","volume":"67","author":"Lee","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"R7-15-20240907","doi-asserted-by":"crossref","first-page":"510.e1","DOI":"10.1016\/j.wneu.2015.10.068","article-title":"Ventriculoperitoneal shunt infection with Mycobacterium abscessus: A rare cause of ventriculitis","volume":"86","author":"Levy","year":"2016","journal-title":"World Neurosurg"},{"key":"R8-15-20240907","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1099\/ijsem.0.002011","article-title":"Reinstating mycobacterium massiliense and mycobacterium bolletii as species of the Mycobacterium abscessus complex","volume":"67","author":"Adekambi","year":"2017","journal-title":"Int J Syst Evol Microbiol"},{"key":"R9-15-20240907","doi-asserted-by":"crossref","first-page":"16415","DOI":"10.1038\/s41598-020-73607-x","article-title":"Subspecies-specific sequence detection for differentiation of Mycobacterium abscessus complex","volume":"10","author":"Minias","year":"2020","journal-title":"Sci Rep"},{"key":"R10-15-20240907","first-page":"ii1","article-title":"British thoracic society guideline for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)","volume":"72","author":"Haworth","year":"2017","journal-title":"BMJ Open Respir Res"},{"key":"R11-15-20240907","first-page":"1120","article-title":"A case of secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome, complicated with disseminated M. abscessus infection","volume":"47","author":"Asai","year":"2009","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"key":"R12-15-20240907","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.amjms.2016.02.009","article-title":"Mycobacterium abscessus as a cause of chronic meningitis: A rare clinical entity","volume":"351","author":"Baidya","year":"2016","journal-title":"Am J Med Sci"},{"key":"R13-15-20240907","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s15010-018-1141-5","article-title":"Incidental intraoperative diagnosis of Mycobacterium abscessus meningeal infection: A case report and review of the literature","volume":"46","author":"Giovannenze","year":"2018","journal-title":"Infection"},{"key":"R14-15-20240907","first-page":"13","article-title":"Mycobacterium abscessus ventriculoperitoneal shunt infection","volume":"13","author":"Herrera","year":"2021","journal-title":"Cureus"},{"key":"R15-15-20240907","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1212\/WNL.56.6.810","article-title":"Neurologic manifestations of disseminated infection with Mycobacterium abscessus","volume":"56","author":"Liebeskind","year":"2001","journal-title":"Neurology"},{"key":"R16-15-20240907","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1086\/322633","article-title":"Hellinger WC, Chu SY, Palmer R, Alvarez-Elcoro SA. Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid","volume":"33","author":"Maniu","year":"2001","journal-title":"Clin Infect Dis"},{"key":"R17-15-20240907","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/INF.0000000000000520","article-title":"Intracranial Mycobacterium abscessus infection in a healthy toddler","volume":"34","author":"Martin","year":"2015","journal-title":"J Pediatr Infect Dis"},{"key":"R18-15-20240907","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s15010-015-0817-3","article-title":"Mycobacterium abscessus ventriculoperitoneal shunt infection and review of the literature","volume":"44","author":"Montero","year":"2016","journal-title":"Infection"},{"key":"R19-15-20240907","first-page":"e7398","article-title":"Nontuberculous mycobacterial infection in patients with neurosurgical hardware: Two cases and a review of the literature","volume":"12","author":"Padmanaban","year":"2020","journal-title":"Cureus"},{"key":"R20-15-20240907","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S1473-3099(08)70127-0","article-title":"Spectrum of CNS disease caused by rapidly growing mycobacteria","volume":"8","author":"Talati","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"R21-15-20240907","doi-asserted-by":"crossref","first-page":"100051","DOI":"10.1016\/j.tcsw.2021.100051","article-title":"Mycobacterium abscessus biofilms produce an extracellular matrix and have a distinct mycolic acid profile","volume":"7","author":"Dokic","year":"2021","journal-title":"Cell Surf"},{"key":"R22-15-20240907","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.chembiol.2013.11.011","article-title":"Mycolic acids: Structures, biosynthesis, and beyond","volume":"21","author":"Marrakchi","year":"2014","journal-title":"Chem Biol"},{"key":"R23-15-20240907","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fmicb.2020.00359","article-title":"Extreme drug tolerance of Mycobacterium abscessus \u201cPersisters","volume":"11","author":"Yam","year":"2020","journal-title":"\u201d Front Microbiol"},{"key":"R24-15-20240907","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.5588\/ijtld.18.0164","article-title":"High-resolution melting curve analysis of heat shock protein 65 for identification of mycobacterial isolates","volume":"22","author":"Singh","year":"2018","journal-title":"Int J Tuberc Lung Dis"},{"key":"R26-15-20240907","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12348-016-0121-0","article-title":"Ocular mycobacteriosis\u2014dual infection of M. tuberculosis complex with M. fortuitum and M. bovis","volume":"7","author":"Sharma","year":"2017","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"R27-15-20240907","doi-asserted-by":"crossref","first-page":"101990","DOI":"10.1016\/j.tube.2020.101990","article-title":"Xpert MTB\/RIF ultra for the diagnosis of tuberculous meningitis: A diagnostic accuracy study from India","volume":"125","author":"Sharma","year":"2020","journal-title":"Tuberculosis"},{"key":"R28-15-20240907","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.5588\/ijtld.14.0701","article-title":"Failure of the MGIT 960 culture system in the detection of Mycobacterium tuberculosis","volume":"18","author":"Sharma","year":"2014","journal-title":"Int J Tuberc Lung Dis"},{"key":"R29-15-20240907","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1128\/JCM.01239-13","article-title":"Matrix-assisted laser desorption ionization-time of flight mass spectrometry can accurately differentiate between Mycobacterium masilliense (M. abscessus subspecies bolletti) and M. abscessus (Sensu Stricto)","volume":"51","author":"Teng","year":"2013","journal-title":"J Clin Microbiol"},{"key":"R30-15-20240907","doi-asserted-by":"crossref","first-page":"715890","DOI":"10.3389\/fchem.2021.715890","article-title":"An improved method for rapid detection of Mycobacterium abscessus complex based on species-specific lipid fingerprint by routine MALDI-TOF","volume":"9","author":"Jia Khor","year":"2021","journal-title":"Front Chem"},{"key":"R31-15-20240907","doi-asserted-by":"crossref","first-page":"e23775","DOI":"10.1097\/MD.0000000000023775","article-title":"Incidence of nontuberculous mycobacterial disease and coinfection with tuberculosis in a tuberculosis-endemic region: A population-based retrospective cohort study","volume":"99","author":"Lin","year":"2020","journal-title":"Med (Baltimore"},{"key":"R32-15-20240907","doi-asserted-by":"crossref","first-page":"12208","DOI":"10.1038\/s41598-021-91757-4","article-title":"Nationwide surveillance of antimicrobial susceptibility of 509 rapidly growing mycobacteria strains isolated from clinical specimens in Japan","volume":"11","author":"Kamada","year":"2021","journal-title":"Sci Rep"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.388095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:14:08Z","timestamp":1787166848000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.388095"}},"subtitle":["Time to Think Beyond Tuberculosis"],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.388095","relation":{},"ISSN":["0028-3886"],"issn-type":[{"value":"0028-3886","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]}}}