{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:04:05Z","timestamp":1787169845426,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Hereditary antithrombin (AT) deficiency is a rare thrombophilia associated with cerebral vein thrombosis (CVT). We report a case study of hereditary AT deficiency causing CVT in three members of a family. A 29-year-old female presented with features of CVT. Her mother and a sister had CVT in the past and investigation for hereditary thrombophilia revealed low blood AT activity in all of them. The index patient (proband) was positive for the\n                      <jats:italic toggle=\"yes\">SERPINC1<\/jats:italic>\n                      gene mutation confirming the diagnosis of hereditary AT deficiency. She recovered well with anticoagulation and was advised to continue it lifelong. Diagnosing hereditary thrombophilia like AT deficiency is important in planning anticoagulation and proper counseling of asymptomatic family members regarding prophylaxis for venous thromboembolism (VTE) in high-risk situations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.388110","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:01:15Z","timestamp":1697612475000},"page":"984-986","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Hereditary Antithrombin Deficiency Presenting with Cerebral Venous Thrombosis in Three Members of a Family"],"prefix":"10.4103","volume":"71","author":[{"given":"V V","family":"Ashraf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K Abdul","family":"Salam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Kizhedath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnan","family":"Puthussery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-22-20240907","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nrneurol.2017.104","article-title":"Cerebral venous thrombosis","volume":"13","author":"Silvis","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"R2-22-20240907","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1055\/s-2007-985754","article-title":"Venous thrombosis at unusual sites and role of thrombophilia","volume":"33","author":"Lussana","year":"2007","journal-title":"Semin Thromb Hemost"},{"key":"R3-22-20240907","first-page":"195","article-title":"Cortical venous thrombosis 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