{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:58Z","timestamp":1787169838331,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Due to effective treatment of middle ear infections there is a change in etiologies causing lateral sinus thrombosis (LST) and outcome. There is a paucity of literature describing homogenous group of patients with nonseptic LST (NS-LST).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe the clinical profile, risk factors, outcome of patients of NS-LST seen at a single center from South India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials:<\/jats:title>\n                    <jats:p>Prospective, observational study of 100 patients of NS-LST patients, diagnosed by magnetic resonance imaging (MRI) seen at the stroke unit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>During 2 years, 100 patients of NS-LST (isolated: combined: 27:73) (male: female: 44:56), mean age: 31.45 \u00b1 11.13 years, were seen. Subacute presentation (74%) with headache, seizures, focal deficits, and features of raised intracranial pressure were presenting features. Hyperhomocysteinemia (61%), anemia (57%), postpartum state (41%), OCP use (37%), and low VitB12 (32%) were commonly seen risk factors. Imaging with MRI compared withcomputerized tomography (CT) had better diagnostic sensitivity (100% vs. 67%), detection of parenchymal (81% vs. 67%)\/hemorrhagic (79% vs. 74%) lesions, and cortical vein thrombosis (31% vs. 15.46%). Treatment with anticoagulation and supportive therapy resulted in good outcome (mRS (0-2)) at 3 months in 81%. There were four deaths, all during admission (one \u2013 isolated, three \u2013 combined) and 11 patients underwent decompressive surgery. Patients with low GCS level of sensoriumat admission, hemiparesis, combined LST, cerebellar involvement, and decompressive craniectomy had a poor outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This single-center large cohort study of NS-LST patients brings out the clinical features, risk factors (peculiar to developing countries), and the superiority of MRI in the diagnosis. Majority of patients have good outcome, with low mortality with 10% requiring decompressive surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.388114","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:01:15Z","timestamp":1697612475000},"page":"916-922","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Profile and Outcome of Prospective Non-Septic Lateral Sinus Thrombosis Patients from a Stroke Unit of a Developing Country"],"prefix":"10.4103","volume":"71","author":[{"given":"Abbas M.","family":"Mirza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish B.","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subasree","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerendrakumar","family":"Mustare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20240907","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.nrl.2010.09.013","article-title":"Cerebral venous thrombosis: A diagnostic and treatment update","volume":"26","author":"Guenther","year":"2011","journal-title":"Neurologia"},{"key":"R2-10-20240907","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00415-004-0321-7","article-title":"Cerebral venous and sinus thrombosis","volume":"251","author":"Masuhr","year":"2004","journal-title":"J Neurol"},{"key":"R3-10-20240907","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1177\/000331978303401107","article-title":"Cerebral venous and arterial thrombosis in pregnancy and puerperium: A study of 135 patients","volume":"34","author":"Srinivasan","year":"1984","journal-title":"Angiology"},{"key":"R4-10-20240907","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/STROKEAHA.107.509711","article-title":"Isolated lateral sinus thrombosis: A series of 62 patients","volume":"40","author":"Damak","year":"2009","journal-title":"Stroke"},{"key":"R5-10-20240907","first-page":"77","article-title":"Clinical presentations of cerebral vein and sinus thrombosis","volume":"23","author":"Paciaroni","year":"2008","journal-title":"Front NeurolNeurosci"},{"key":"R6-10-20240907","doi-asserted-by":"crossref","first-page":"e2010027","DOI":"10.4084\/mjhid.2010.027","article-title":"Lateralsinusthrombosisin otology: A review","volume":"2","author":"Viswanatha","year":"2010","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"R7-10-20240907","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s12070-011-0199-5","article-title":"Pseudomastoiditis in lateral sinus thrombosis: A rare presentation with review of literature","volume":"63","author":"Thota","year":"2011","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"R8-10-20240907","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/00005537-199705000-00023","article-title":"Nonseptic lateral sinus thrombosis: The otolaryngologic perspective","volume":"107","author":"Rosen","year":"1997","journal-title":"Laryngoscope"},{"key":"R9-10-20240907","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1148\/rg.26si055174","article-title":"Imagingofcerebralvenousthrombosis: Currenttechniques, spectrumoffindings anddiagnostic pitfalls","volume":"26","author":"Leach","year":"2006","journal-title":"Radiographics"},{"key":"R10-10-20240907","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(07)70029-7","article-title":"Cerebral venous thrombosis: An update","volume":"6","author":"Bousser","year":"2007","journal-title":"Lancet Neurol"},{"key":"R14-10-20240907","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11239-017-1518-9","article-title":"Preliminary data on utility of subcutaneous unfractionated heparin in patients with deep cerebral venous thrombosis","volume":"44","author":"Kulkarni","year":"2017","journal-title":"J Thromb Thrombolysis"},{"key":"R15-10-20240907","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/003693305700200504","article-title":"Cerebral vascular accidents in patients over the age of 60. 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