{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:43:05Z","timestamp":1786725785544,"version":"build-2736575974"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>Neuromyelitis Optica (NMO) is a demyelinating disease predominantly involving optic nerves, spinal cord and peri-ventricular regions which are rich in Aquaporin-4 receptors. Aquaporin-4 (AQP4) antibodies are implicated in the pathogenesis of NMO. Association of hydrocephalus (communicating and non communicating) with NMO is very rare. We report a case of 32 years old female patient who presented with 2 months history of progressive headache, visual obscurations and gait imbalance. Clinical examination revealed bilateral papilloedema with preserved visual acuity. She had truncal and gait ataxia. Rest of the examination of nervous system was normal. MRI brain showed non- communicating hydrocephalus and T2 and FLAIR hyperintensities in periventricular and periaqueductal regions. AQP4 antibodies were positive in serum and negative in cerebrospinal fluid(CSF). Ventriculo - peritoneal shunt was placed and she was treated with steroids and azathioprine. Her headache and visual symptoms improved. However, after 8 months she presented with acute optic neuritis of right eye which was treated with intravenous methylprednisolone and plasmapharaesis.<\/jats:p>","DOI":"10.4103\/0028-3886.391387","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T11:07:47Z","timestamp":1704280067000},"page":"1239-1240","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Neuromyelitis Optica Presenting as Non-Communicating Hydrocephalus: A Case Report"],"prefix":"10.4103","volume":"71","author":[{"given":"Shalesh","family":"Rohatgi","sequence":"first","affiliation":[{"name":"Department of Neurology, Dr D Y Patil Medical College, Hospital and Research Center, Dr DY Patil Vidyapeeth Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajwal","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dr D Y Patil Medical College, Hospital and Research Center, Dr DY Patil Vidyapeeth Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Nirhale","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dr D Y Patil Medical College, Hospital and Research Center, Dr DY Patil Vidyapeeth Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Naphade","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dr D Y Patil Medical College, Hospital and Research Center, Dr DY Patil Vidyapeeth Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sravya","family":"Kotharu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dr D Y Patil Medical College, Hospital and Research Center, Dr DY Patil Vidyapeeth Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dr D Y Patil Medical College, Hospital and Research Center, Dr DY Patil Vidyapeeth Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"R1-20260511","article-title":"Unexplained hydrocephalus in a patient with neuromyelitis optica","author":"Gratton","year":"2013","journal-title":"North American Neuro-Ophthalmology Society Annual Meeting, San Antonio,"},{"key":"R2-20260511","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1212\/WNL.0000000000000428","article-title":"Hydrocephalus in neuromyelitis optica","volume":"82","author":"Clardy","year":"2014","journal-title":"Neurology"},{"key":"R3-20260511","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.wneu.2019.05.177","article-title":"Acute hydrocephalus resulting from neuromyelitis optica: A case report and review of the literature","volume":"129","author":"Close","year":"2019","journal-title":"World Neurosurg"},{"key":"R4-20260511","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00401-017-1682-1","article-title":"Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica","volume":"133","author":"Guo","year":"2017","journal-title":"Acta Neuropathol"},{"key":"R5-20260511","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1007\/s00415-020-10122-z","article-title":"Role of aquaporins in hydrocephalus: What do we know and where do we stand? A systematic review","volume":"268","author":"de Laurentis","year":"2021","journal-title":"J Neurol"},{"key":"R6-20260511","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.jns.2017.08.3013","article-title":"Hydrocephalus in neuromyelitis optica spectrum disorder: A case report and literature review","volume":"381","author":"Chibaa","year":"2017","journal-title":"J Neurol Sci"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.391387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:25:42Z","timestamp":1786724742000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.391387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.391387","relation":{},"ISSN":["0028-3886","1998-4022"],"issn-type":[{"value":"0028-3886","type":"print"},{"value":"1998-4022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2021-12-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}