{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:32:00Z","timestamp":1787758320705,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>\n                    A 42-year-old immunocompetent man presented with subacute onset unilateral headache and associated lower cranial nerve palsies. Cranial magnetic resonance imaging showed enhancing thickened tentorium cerebelli and subtentorial dura mater. Cerebrospinal fluid examination revealed lymphocytic pleocytosis and positive polymerase chain reaction assay of\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    DNA. While on voriconazole treatment a progressive increase was noted in subtentorial pachymeningeal hypertrophy, which was excised because of critical compression of the medulla. The excision material showed extensive fibrosis, cellular infiltrates and no organisms. With combination therapy with anti-fungal agents and corticosteroids, pachymeningitis showed regression. We hypothesised that intact immune status and less burden of\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    infection in this patient may have resulted in a chronic progressive hypertrophic pachymeningitis.\n                  <\/jats:p>","DOI":"10.4103\/0028-3886.76886","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:23:05Z","timestamp":1302268985000},"page":"111-113","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Hypertrophic pachymeningitis in an immunocompetent adult with positive Aspergillus DNA in the cerebrospinal fluid"],"prefix":"10.4103","volume":"59","author":[{"given":"Hirotaka","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Neurology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Neurology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Neurology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2011,2,18]]},"reference":[{"key":"R1-20260605","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1212\/WNL.43.7.1329","article-title":"Cranial pachymeningitis of unknown origin: A study of seven cases","volume":"43","author":"Masson","year":"1993","journal-title":"Neurology"},{"key":"R2-20260605","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1128\/jcm.33.12.3115-3118.1995","article-title":"Plasma (1\u00ae3)-b-D-glucan and fungal antigenemia in patients with candidemia, aspergillosis, and cryptococcosis","volume":"33","author":"Miyazaki","year":"1995","journal-title":"J Clin Microbiol"},{"key":"R3-20260605","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1086\/323337","article-title":"Use of real-time PCR on blood samples for diagnosis of invasive aspergillosis","volume":"33","author":"Kami","year":"2001","journal-title":"Clin Infect Dis"},{"key":"R4-20260605","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1128\/JCM.37.4.1186-1189.1999","article-title":"Aspergillus meningitis: Diagnosis by non-culture-based microbiological methods and management","volume":"37","author":"Verweij","year":"1999","journal-title":"J Clin Microbiol"},{"key":"R5-20260605","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1128\/JCM.00466-06","article-title":"Detection of Aspergillus DNA in cerebrospinal fluid from patients with cerebral aspergillosis by a nested PCR assay","volume":"44","author":"Hummel","year":"2006","journal-title":"J Clin Microbiol"},{"key":"R6-20260605","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00701-005-0659-3","article-title":"Diagnostic MR imaging features of craniocerebral Aspergillosis of sino-nasal origin in immunocompetent patients","volume":"148","author":"Siddiqui","year":"2006","journal-title":"Acta Neurochir (Wien)"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223311-201159010-00028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:09:48Z","timestamp":1787756988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223311-201159010-00028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.76886","relation":{},"ISSN":["0028-3886","1998-4022"],"issn-type":[{"value":"0028-3886","type":"print"},{"value":"1998-4022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"2010-10-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-10-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}