{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:02:30Z","timestamp":1788436950429,"version":"build-2803163510"},"reference-count":68,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Pharmacol"],"published-print":{"date-parts":[[2015]]},"DOI":"10.4103\/0253-7613.150305","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T02:42:33Z","timestamp":1422585753000},"page":"4","source":"Crossref","is-referenced-by-count":52,"title":["Diabetes-associated depression: The serotonergic system as a novel multifunctional target"],"prefix":"10.4103","volume":"47","author":[{"given":"Deepali","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visakh","family":"Prabhakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek","family":"Kanade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Radhakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0253-7613.150305-1","first-page":"302","volume-title":"Diabetes and depression: Global perspectives","author":"Egede","year":"2010","journal-title":"Diabetes Res Clin Pract"},{"key":"key-10.4103\/0253-7613.150305-2","first-page":"1069","volume-title":"The prevalence of comorbid depression in adults with diabetes: A meta-analysis","author":"Anderson","year":"2001","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0253-7613.150305-3","first-page":"18","volume-title":"Subsyndromal symptomatic depression: A new mood disorder?","author":"Judd","year":"1994","journal-title":"J Clin Psychiatry"},{"key":"key-10.4103\/0253-7613.150305-4","first-page":"602","volume-title":"Similarity of depression in diabetic and psychiatric patients","author":"Lustman","year":"1992","journal-title":"Psychosom Med"},{"key":"key-10.4103\/0253-7613.150305-5","first-page":"196","volume-title":"Relationship between retinopathy severity, visual impairment and depression in persons with long-term type 1 diabetes","author":"Hirai","year":"2012","journal-title":"Ophthalmic Epidemiol"},{"key":"key-10.4103\/0253-7613.150305-6","first-page":"1066","volume-title":"Diabetes, depression, and quality of life: A population study","author":"Goldney","year":"2004","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0253-7613.150305-7","first-page":"2154","volume-title":"Relationship of depression and diabetes self-care, medication adherence, and preventive care","author":"Lin","year":"2004","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0253-7613.150305-8","first-page":"155","volume-title":"Pathophysiology of depression: Do we have any solid evidence of interest to clinicians?","author":"Hasler","year":"2010","journal-title":"World Psychiatry"},{"key":"key-10.4103\/0253-7613.150305-9","first-page":"2030","volume-title":"Neurobiology of depression: An integrated view of key findings","author":"Maletic","year":"2007","journal-title":"Int J Clin Pract"},{"key":"key-10.4103\/0253-7613.150305-10","first-page":"4","volume-title":"History and evolution of the monoamine hypothesis of depression","author":"Hirschfeld","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"key-10.4103\/0253-7613.150305-11","first-page":"500","volume-title":"Learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: Interaction of diabetes and ageing","author":"Kamal","year":"2000","journal-title":"Diabetologia"},{"key":"key-10.4103\/0253-7613.150305-12","first-page":"11056","volume-title":"Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress","author":"Magari\u00f1os","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/0253-7613.150305-13","first-page":"1600","volume-title":"Diabetes increases atrophy and vascular lesions on brain MRI in patients with symptomatic arterial disease","author":"Tiehuis","year":"2008","journal-title":"Stroke"},{"key":"key-10.4103\/0253-7613.150305-14","first-page":"237","volume-title":"Memory-improving actions of glucose: Involvement of a central cholinergic muscarinic mechanism","author":"Kopf","year":"1994","journal-title":"Behav Neural Biol"},{"key":"key-10.4103\/0253-7613.150305-15","first-page":"2378","volume-title":"Diabetic peripheral neuropathy and depressive symptoms: The association revisited","author":"Vileikyte","year":"2005","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0253-7613.150305-16","first-page":"1539","volume-title":"Reduced hippocampal neurogenesis and number of hilar neurones in streptozotocin-induced diabetic mice: Reversion by antidepressant treatment","author":"Beauquis","year":"2006","journal-title":"Eur J Neurosci"},{"key":"key-10.4103\/0253-7613.150305-17","first-page":"125","volume-title":"Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: Effects of insulin treatment","author":"Biessels","year":"1998","journal-title":"Brain Res"},{"key":"key-10.4103\/0253-7613.150305-18","first-page":"646","volume-title":"Insulin receptor signaling in long-term memory consolidation following spatial learning","author":"Dou","year":"2005","journal-title":"Learn Mem"},{"key":"key-10.4103\/0253-7613.150305-19","first-page":"259","volume-title":"Serotonin modulation of cerebral glucose metabolism in depressed older adults","author":"Smith","year":"2009","journal-title":"Biol Psychiatry"},{"key":"key-10.4103\/0253-7613.150305-20","first-page":"343","volume-title":"Association between serotonin transporter promoter polymorphisms and psychological distress in a diabetic population","author":"Wilhelm","year":"2012","journal-title":"Psychiatry Res"},{"key":"key-10.4103\/0253-7613.150305-21","first-page":"1588","volume-title":"Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression","author":"Zalsman","year":"2006","journal-title":"Am J Psychiatry"},{"key":"key-10.4103\/0253-7613.150305-22","first-page":"293","volume-title":"Changes in cerebra serotonin synthesis induced by insulin-dependent diabetes mellitus","author":"Manjarrez-Guti\u00e9rrez","year":"1999","journal-title":"Rev Invest Clin"},{"key":"key-10.4103\/0253-7613.150305-23","first-page":"57","volume-title":"Inhibition and kinetic changes of brain tryptophan-5-hydroxylase during insulin-dependent diabetes mellitus in the rat","author":"Herrera","year":"2005","journal-title":"Nutr Neurosci"},{"key":"key-10.4103\/0253-7613.150305-24","first-page":"461","volume-title":"Diabetes attenuates the antidepressant-like effect mediated by the activation of 5-HT1A receptor in the mouse tail suspension test","author":"Miyata","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"key-10.4103\/0253-7613.150305-25","first-page":"1393","volume-title":"Streptozotocin-induced diabetes provokes changes in serotonin concentration and on 5-HT1A and 5-HT2 receptors in the rat brain","author":"Sandrini","year":"1997","journal-title":"Life Sci"},{"key":"key-10.4103\/0253-7613.150305-26","first-page":"1607","volume-title":"Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression","author":"Mocking","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"key-10.4103\/0253-7613.150305-27","first-page":"925","volume-title":"Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders","author":"Sapolsky","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"key-10.4103\/0253-7613.150305-28","first-page":"2439","volume-title":"Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes","author":"Bruehl","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/0253-7613.150305-29","first-page":"108","volume-title":"Allostasis and allostatic load: Implications for neuropsychopharmacology","author":"McEwen","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"key-10.4103\/0253-7613.150305-30","first-page":"252","volume-title":"The therapeutic role of 5-HT1A and 5-HT2A receptors in depression","author":"Celada","year":"2004","journal-title":"J Psychiatry Neurosci"},{"key":"key-10.4103\/0253-7613.150305-31","first-page":"433","volume-title":"Modulation of 5HT1A responsiveness in CA1 pyramidal neurons by in vivo activation of corticosteroid receptors","author":"Hesen","year":"1996","journal-title":"J Neuroendocrinol"},{"key":"key-10.4103\/0253-7613.150305-32","first-page":"4400","volume-title":"HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience","author":"Espallergues","year":"2012","journal-title":"J Neurosci"},{"key":"key-10.4103\/0253-7613.150305-33","first-page":"371","volume-title":"Colocalization of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and hypothalamus","author":"Han","year":"2005","journal-title":"Neurosci Res"},{"key":"key-10.4103\/0253-7613.150305-34","first-page":"6956","volume-title":"Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation","author":"Heisler","year":"2007","journal-title":"J Neurosci"},{"key":"key-10.4103\/0253-7613.150305-35","first-page":"1891","volume-title":"Function of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system in models of acute stress in domestic farm animals","author":"Minton","year":"1994","journal-title":"J Anim Sci"},{"key":"key-10.4103\/0253-7613.150305-36","first-page":"431","volume-title":"Brain-derived neurotrophic factor (BDNF) and type 2 diabetes","author":"Krabbe","year":"2007","journal-title":"Diabetologia"},{"key":"key-10.4103\/0253-7613.150305-37","doi-asserted-by":"crossref","unstructured":"Martinowich K, Lu B. Interaction between BDNF and serotonin: Role in mood disorders. Neuropsychopharmacology 2008;33:73-83.","DOI":"10.1038\/sj.npp.1301571"},{"key":"key-10.4103\/0253-7613.150305-38","first-page":"5","volume-title":"Understanding depression: Linking brain-derived neurotrophic factor, transglutaminase 2 and serotonin","author":"Hashimoto","year":"2013","journal-title":"Expert Rev Neurother"},{"key":"key-10.4103\/0253-7613.150305-39","first-page":"230","volume-title":"Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats","author":"Grillo","year":"2011","journal-title":"Behav Brain Res"},{"key":"key-10.4103\/0253-7613.150305-40","first-page":"1219","volume-title":"Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats","author":"Burguera","year":"2000","journal-title":"Diabetes"},{"key":"key-10.4103\/0253-7613.150305-41","first-page":"382","volume-title":"Towards a serotonin-dependent leptin roadmap in the brain","author":"Oury","year":"2011","journal-title":"Trends Endocrinol Metab"},{"key":"key-10.4103\/0253-7613.150305-42","first-page":"1","volume-title":"GSK3beta: Role in therapeutic landscape and development of modulators","author":"Phukan","year":"2010","journal-title":"Br J Pharmacol"},{"key":"key-10.4103\/0253-7613.150305-43","first-page":"1","volume-title":"GSK3 takes centre stage more than 20 years after its discovery","author":"Frame","year":"2001","journal-title":"Biochem J"},{"key":"key-10.4103\/0253-7613.150305-44","first-page":"785","volume-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"key-10.4103\/0253-7613.150305-45","first-page":"1426","volume-title":"In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain","author":"Li","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"key-10.4103\/0253-7613.150305-46","first-page":"1421","volume-title":"Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions","author":"Jope","year":"2006","journal-title":"Curr Drug Targets"},{"key":"key-10.4103\/0253-7613.150305-47","first-page":"6846","volume-title":"Serotonin receptor activation inhibits sodium current and dendritic excitability in prefrontal cortex via a protein kinase C-dependent mechanism","author":"Carr","year":"2002","journal-title":"J Neurosci"},{"key":"key-10.4103\/0253-7613.150305-48","first-page":"542","volume-title":"Cognition and synaptic plasticity in diabetes mellitus","author":"Gispen","year":"2000","journal-title":"Trends Neurosci"},{"key":"key-10.4103\/0253-7613.150305-49","first-page":"326","volume-title":"Cognitive role of neurogenesis in depression and antidepressant treatment","author":"Perera","year":"2008","journal-title":"Neuroscientist"},{"key":"key-10.4103\/0253-7613.150305-50","first-page":"394","volume-title":"Reduced hippocampal cell differentiation in the subgranular zone of the dentate gyrus in a rat model of type II diabetes","author":"Hwang","year":"2008","journal-title":"Neurochem Res"},{"key":"key-10.4103\/0253-7613.150305-51","first-page":"999","volume-title":"Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats","author":"Brezun","year":"1999","journal-title":"Neuroscience"},{"key":"key-10.4103\/0253-7613.150305-52","first-page":"2896","volume-title":"Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus","author":"Aberg","year":"2000","journal-title":"J Neurosci"},{"key":"key-10.4103\/0253-7613.150305-53","first-page":"45","volume-title":"Glutamate release in human cerebral cortex and its modulation by 5-hydroxytryptamine acting at h 5-HT1D receptors","author":"Maura","year":"1998","journal-title":"Br J Pharmacol"},{"key":"key-10.4103\/0253-7613.150305-54","first-page":"5682","volume-title":"Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic \u00df cells","author":"Isaac","year":"2013","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0253-7613.150305-55","first-page":"1974","volume-title":"Obesity, dyslipidemia, and diabetes with selective serotonin reuptake inhibitors: The hordaland health study","author":"Raeder","year":"2006","journal-title":"J Clin Psychiatry"},{"key":"key-10.4103\/0253-7613.150305-56","first-page":"391","volume-title":"The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling","author":"Grimes","year":"2001","journal-title":"Prog Neurobiol"},{"key":"key-10.4103\/0253-7613.150305-57","first-page":"1223","volume-title":"Glycogen synthase kinase-3: A putative molecular target for lithium mimetic drugs","author":"Gould","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"key-10.4103\/0253-7613.150305-58","unstructured":"Cooper AJ, Ashcroft G. Potentiation of insulin hypoglycaemia by M.A.O.I. antidepressant drugs. Lancet 1966;1:407-9."},{"key":"key-10.4103\/0253-7613.150305-59","first-page":"214","volume-title":"Biochemistry and pharmacology of reversible inhibitors of MAO-A agents: Focus on moclobemide","author":"Nair","year":"1993","journal-title":"J Psychiatry Neurosci"},{"key":"key-10.4103\/0253-7613.150305-60","first-page":"1049","volume-title":"Bupropion SR vs.placebo for weight loss in obese patients with depressive symptoms","author":"Jain","year":"2002","journal-title":"Obes Res"},{"key":"key-10.4103\/0253-7613.150305-61","first-page":"241","volume-title":"Effects of nortriptyline on depression and glycemic control in diabetes: Results of a double-blind, placebo-controlled trial","author":"Lustman","year":"1997","journal-title":"Psychosom Med"},{"key":"key-10.4103\/0253-7613.150305-62","first-page":"336","volume-title":"Antidepressant-like effect of pioglitazone in the forced swimming test in mice: The role of PPAR-gamma receptor and nitric oxide pathway","author":"Sadaghiani","year":"2011","journal-title":"Behav Brain Res"},{"key":"key-10.4103\/0253-7613.150305-63","first-page":"22","volume-title":"Safety and efficacy of duloxetine in the treatment of diabetic peripheral neuropathic pain in older patients","author":"Wasan","year":"2009","journal-title":"Curr Drug Saf"},{"key":"key-10.4103\/0253-7613.150305-64","first-page":"9","volume-title":"Treatment of patients with comorbid depression and diabetes with metformin and milnacipran","author":"Hofmann","year":"2010","journal-title":"Neuropsychiatr Dis Treat"},{"key":"key-10.4103\/0253-7613.150305-65","first-page":"206","volume-title":"Recommendations for nutrition best practice in the management of gestational diabetes mellitus.Executive summary (1)","author":"Canadian","year":"2006","journal-title":"Can J Diet Pract Res"},{"key":"key-10.4103\/0253-7613.150305-66","first-page":"1","volume-title":"A review of treating depression in diabetes: Emerging findings","author":"Markowitz","year":"2011","journal-title":"Psychosomatics"},{"key":"key-10.4103\/0253-7613.150305-67","first-page":"196","volume-title":"Glucocorticoid regulation of brain-derived neurotrophic factor: Relevance to hippocampal structural and functional plasticity","author":"Suri","year":"2013","journal-title":"Neuroscience"},{"key":"key-10.4103\/0253-7613.150305-68","first-page":"1","volume-title":"A simple role for BDNF in learning and memory?","author":"Cunha","year":"2010","journal-title":"Front Mol Neurosci"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:31:53Z","timestamp":1786649513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0253-7613.150305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015]]}},"alternative-id":["150305"],"URL":"https:\/\/doi.org\/10.4103\/0253-7613.150305","relation":{},"ISSN":["0253-7613"],"issn-type":[{"value":"0253-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}