{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:30:41Z","timestamp":1786739441735,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This study compared the effectiveness of prophylactic administration of topical flurbiprofen 0.03% and nepafenac 0.1% in maintaining mydriasis during small incision cataract surgery (SICS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This study was a prospective, randomized, double-blind comparative study in adult cataract patients given topical flurbiprofen or nepafenac prior to SICS and capsular bag intraocular lens (IOL) implantation at a tertiary care hospital. Horizontal and vertical diameters of pupil were measured at the beginning and end of surgery, and the mean values were compared across the two groups. Unpaired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test and Fisher's exact test were used to analyse the results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 70 eyes of cataract surgery patients, 33 males and 37 females, with a mean age of 58.5 \u00b1 11.24 years, were included in the study. The mean horizontal and vertical diameters of the two groups were similar at the start of surgery. Significant differences were seen after IOL implantation, with the nepafenac group having the larger mean diameters in both horizontal (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03) and vertical (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04) pupillary measurements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Topical nepafenac has been shown to be a more effective inhibitor of meiosis during SICS and provides a more stable mydriatic effect compared to topical flurbiprofen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0253-7613.165201","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T06:44:00Z","timestamp":1442385840000},"page":"491-495","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of preoperative nepafenac (0.1%) and flurbiprofen (0.03%) eye drops in maintaining mydriasis during small incision cataract surgery in patients with senile cataract: A randomized, double-blind study"],"prefix":"10.4103","volume":"47","author":[{"given":"Saumya","family":"Sarkar","sequence":"first","affiliation":[{"name":"Department of Pharmacology, R.G. Kar M.C. and H, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchan Kumar","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, R.G. Kar M.C. and H, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukalyan Saha","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, R.G. Kar M.C. and H, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmistha","family":"Gayen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, R.G. Kar M.C. and H, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine and J.N.M. Hospital, Kalyani, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha Raman","family":"De","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, R.G. Kar M.C. and H, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20260528","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00055735-199902000-00006","article-title":"Preoperative and postoperative medications used for cataract surgery","volume":"10","author":"Rowen","year":"1999","journal-title":"Curr Opin Ophthalmol"},{"key":"R3-20260528","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0161-6420(87)33424-4","article-title":"Risk factors for intraoperative complications in 1000 extracapsular cataract cases","volume":"94","author":"Guzek","year":"1987","journal-title":"Ophthalmology"},{"key":"R4-20260528","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/sj.eye.6700124","article-title":"Naproxen Study Group. Topical naproxen sodium for inhibition of miosis during cataract surgery. Prospective, randomized clinical trials","volume":"16","author":"Papa","year":"2002","journal-title":"Eye (Lond)"},{"key":"R5-20260528","first-page":"637","article-title":"Prostaglandins, nonsteroidal anti-inflammatory agents and eye disease","volume":"74","author":"Podos","year":"1976","journal-title":"Trans Am Ophthalmol Soc"},{"key":"R6-20260528","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1136\/bjo.2004.046003","article-title":"A system for preoperative stratification of cataract patients according to risk of intraoperative complications: A prospective analysis of 1441 cases","volume":"88","author":"Muhtaseb","year":"2004","journal-title":"Br J Ophthalmol"},{"key":"R7-20260528","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1001\/archopht.1997.01100160289004","article-title":"Topical 0.5% ketorolac vs. 003% flurbiprofen for inhibition of miosis during cataract surgery","volume":"115","author":"Solomon","year":"1997","journal-title":"Arch Ophthalmol"},{"key":"R8-20260528","first-page":"474","article-title":"Effect of flurbiprofen and dexamethasone acetate in prevention of surgically induced miosis during cataract surgery","volume":"7","author":"Abdel","year":"2011","journal-title":"J Am Sci"},{"key":"R9-20260528","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/01.iio.0000212129.53019.49","article-title":"Nepafenac: A unique nonsteroidal prodrug","volume":"46","author":"Lane","year":"2006","journal-title":"Int Ophthalmol Clin"},{"key":"R10-20260528","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.jcrs.2007.05.015","article-title":"In vivo pharmacokinetics and in vitro pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac","volume":"33","author":"Walters","year":"2007","journal-title":"J Cataract Refract Surg"},{"key":"R11-20260528","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1023\/A:1007001131987","article-title":"Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers","volume":"24","author":"Ke","year":"2000","journal-title":"Inflammation"},{"key":"R12-20260528","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1185\/030079906X89775","article-title":"Ocular permeation and inhibition of retinal inflammation: An examination of data and expert opinion on the clinical utility of nepafenac","volume":"22","author":"Lindstrom","year":"2006","journal-title":"Curr Med Res Opin"},{"key":"R13-20260528","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2147\/OPTH.S4820","article-title":"Inhibition of surgically induced miosis and prevention of postoperative macular edema with nepafenac","volume":"3","author":"Cervantes-Coste","year":"2009","journal-title":"Clin Ophthalmol"},{"key":"R14-20260528","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0039-6257(92)90095-B","article-title":"Cyclo-oxygenase inhibitors in ophthalmology","volume":"36","author":"Flach","year":"1992","journal-title":"Surv Ophthalmol"},{"key":"R15-20260528","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1023\/A:1007049015148","article-title":"Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy","volume":"24","author":"Gamache","year":"2000","journal-title":"Inflammation"},{"key":"R16-20260528","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0161-6420(00)00366-3","article-title":"Discussion: Ketorolac versus prednisolone versus combination therapy in the treatment of acute pseudophakic cystoid macular edema","volume":"107","author":"Flach","year":"2000","journal-title":"Ophthalmology"},{"issue":"Suppl","key":"R17-20260528","first-page":"S289","article-title":"Efficacy of topical Voltaren in reducing the incidence of postoperative cystoids macular edema","volume":"409","author":"McColgin","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R18-20260528","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/S0886-3350(03)00137-8","article-title":"Prednisolone and flurbiprofen drops to maintain mydriasis during phacoemulsification cataract surgery","volume":"29","author":"Shaikh","year":"2003","journal-title":"J Cataract Refract Surg"},{"key":"R19-20260528","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0886-3350(96)80045-9","article-title":"Intraocular availability and pupillary effect of flurbiprofen and indomethacin during cataract surgery","volume":"22","author":"Gimbel","year":"1996","journal-title":"J Cataract Refract Surg"},{"key":"R20-20260528","first-page":"474","article-title":"Effect of flurbiprofen and dexamethasone acetate in prevention of surgically induced miosis during cataract surgery","volume":"7","author":"Mahdy","year":"2011","journal-title":"J Am Sci"},{"key":"R21-20260528","first-page":"23","article-title":"Effect of topical ketorolac tromethamine and topical nepafenac on maintaining pupillary dilation during phacoemulsification","volume":"36","author":"Atanis","year":"2011","journal-title":"Philipp J Ophthalmol"},{"key":"R22-20260528","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.jcrs.2006.04.009","article-title":"Preoperative ketorolac tromethamine 0.4% in phacoemulsification outcomes: Pharmacokinetic-response curve","volume":"32","author":"Donnenfeld","year":"2006","journal-title":"J Cataract Refract Surg"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363791-201547050-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:29:01Z","timestamp":1786735741000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0253-7613.165201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0253-7613.165201","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"2015-02-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}