{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:26:02Z","timestamp":1787772362043,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      The study was designed to evaluate possible antihistaminic and anticholinergic activities of\n                      <jats:italic toggle=\"yes\">Equisetum debile<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Effects of crude ethanolic (Ed.Eth) and effects of crude aqueous (Ed.Aq) extracts of\n                      <jats:italic toggle=\"yes\">E. debile<\/jats:italic>\n                      were studied using isolated guinea pig ileum, rabbit jejunum, and rabbit trachea. Tissue responses were recorded using isotonic and isometric transducers, connected with PowerLab data acquisition system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A dose-dependent (0.1\u20130.3 mg\/ml) rightward shift was demonstrated in histamine concentration-response curves. Whereas a complete relaxation of carbachol (1 \u03bcM)-induced contractions in isolated rabbit jejunum (3 mg\/ml) and tracheal (10 mg\/ml) preparations was observed, similar to dicyclomine at 1 and 3 \u03bcM, respectively. However, no significant difference between the effects of Ed.Eth and Ed.Aq was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Study provides pharmacological evidence for the presence of antihistaminic and anticholinergic activities in crude extracts of\n                      <jats:italic toggle=\"yes\">E. debile<\/jats:italic>\n                      and also highlight its medicinal significance in the management of airway and gastrointestinal disorders.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0253-7613.201017","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:04:50Z","timestamp":1716476690000},"page":"98-101","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["A pharmacological evidence for 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