{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:17:51Z","timestamp":1787847471330,"version":"build-2784847793"},"reference-count":3,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Adverse drug effects that are uncommon or appear only on chronic administration of a drug may not be detected in clinical trials. This explains the need of strict post-marketing vigilance on drug use. Phenytoin administration has been shown in the literature to be associated with development of neoplasia (benign\/malignant). In our knowledge current work represents the first case of pleomorphic-adenoma of sub-mandibular salivary gland developed following chronic phenytoin use. A 40 year old male having a history of head trauma twenty years back, had been on tablet phenytoin 100 mg thrice daily since then. One year back he noticed a small swelling in left sub-mandibular region and gradually increasing in size. FNAC and CECT revealed the diagnosis of pleomorphic-adenoma of sub-mandibular salivary gland. Other causes were ruled out. Surgical excision was performed successfully and continuing follow-up with no recurrence at the end of 6 months. Histo-pathogical examination of the tissue did not show any malignant changes.<\/jats:p>","DOI":"10.4103\/0253-7613.201018","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:04:50Z","timestamp":1716476690000},"page":"130-131","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Chronic administration of phenytoin and pleomorphic adenoma: A case report and review of literature"],"prefix":"10.4103","volume":"49","author":[{"given":"Vikas","family":"Maharshi","sequence":"first","affiliation":[{"name":"Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravesh","family":"Nagar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, LHMC, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260528","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2174\/157015909788848866","article-title":"Antiepileptic drug monotherapy: The initial approach in epilepsy management","volume":"7","author":"St. Louis","year":"2009","journal-title":"Curr Neuropharmacol"},{"key":"R2-20260528","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3810\/pgm.2011.09.2475","article-title":"Key concepts of clinical trials: A narrative review","volume":"123","author":"Umscheid","year":"2011","journal-title":"Postgrad Med"},{"issue":"Pt 1","key":"R3-20260528","first-page":"7","article-title":"Cancer risk in people with epilepsy: The role of antiepileptic drugs","volume":"128","author":"Singh","year":"2005","journal-title":"Brain"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363791-201749010-00027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:19:29Z","timestamp":1787843969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363791-201749010-00027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":3,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/0253-7613.201018","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2016-07-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}