{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:37Z","timestamp":1787772457007,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Drug-induced leukocytoclastic vasculitis is a small-vessel vasculitis that most commonly manifests with palpable purpuric lesions on gravity-dependent areas. Vasculitis occurs within weeks after initial administration of medication and demonstrates clearance upon withdrawal of medication. Levetiracetam, a pyrrolidone derivative, is used as an adjunctive therapy in patients with refractory focal epilepsy, myoclonic epilepsy, and primary generalized tonic\u2013clonic seizures. We present a case of a 14-year-old female, who developed cutaneous small-vessel vasculitis within 8 days of initiation of levetiracetam. Vasculitis was successfully managed by discontinuation of medication and systemic corticosteroids. This adverse reaction, to the best of our knowledge, has not been previously reported in literature.<\/jats:p>","DOI":"10.4103\/0253-7613.201020","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:04:50Z","timestamp":1716476690000},"page":"124-126","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Levetiracetam-induced leukocytoclastic vasculitis"],"prefix":"10.4103","volume":"49","author":[{"given":"Mrinal","family":"Gupta","sequence":"first","affiliation":[{"name":"Treatwell Skin Centre, Jammu, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260528","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0889-857X(05)70239-8","article-title":"Drug-induced vasculitis","volume":"27","author":"Merkel","year":"2001","journal-title":"Rheum Dis Clin North Am"},{"key":"R2-20260528","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1067\/mjd.2003.212","article-title":"Cutaneous vasculitis","volume":"48","author":"Fiorentino","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"R4-20260528","first-page":"2229","article-title":"Preventability and severity assessment in reporting adverse drug reactions","volume":"49","author":"Hartwig","year":"1992","journal-title":"Am J Hosp Pharm"},{"key":"R5-20260528","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"R7-20260528","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/BOR.0b013e3282f1331f","article-title":"Drug-induced vasculitis","volume":"20","author":"Wiik","year":"2008","journal-title":"Curr Opin Rheumatol"},{"key":"R8-20260528","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1345\/aph.1A124","article-title":"Cutaneous and systemic manifestations of drug-induced vasculitis","volume":"36","author":"ten Holder","year":"2002","journal-title":"Ann Pharmacother"},{"key":"R9-20260528","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1527-3458.2007.00005.x","article-title":"Levetiracetam: Part II, the clinical profile of a novel anticonvulsant drug","volume":"13","author":"De Smedt","year":"2007","journal-title":"CNS Drug Rev"},{"key":"R10-20260528","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3109\/15569527.2012.725444","article-title":"A case of levetiracetam induced bullous pemphigoid","volume":"32","author":"Karadag","year":"2013","journal-title":"Cutan Ocul Toxicol"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363791-201749010-00025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:47:43Z","timestamp":1787770063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363791-201749010-00025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/0253-7613.201020","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2016-08-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}