{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:42:14Z","timestamp":1788309734526,"version":"build-2803163510"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Erythroderma is characterized by diffuse erythema and scaling of the skin involving more than 90% of the total body skin surface area. Drug-induced erythroderma has rarely been reported with hydroxychloroquine. We report a case of a 50-year-old female patient, with systemic lupus erythematosus, who developed itchy lesions all over the body 1 month after starting treatment with hydroxychloroquine. Drug-induced erythroderma was suspected. Hydroxychloroquine was withdrawn and the patient was treated with emollients, mid-potency corticosteroids, and oral antihistamines. A biopsy was done which confirmed the diagnosis of erythroderma. She recovered with treatment and was discharged. A careful history and clinical examination to search for potential causative factors will help prevent disabling sequelae in erythroderma.<\/jats:p>","DOI":"10.4103\/0253-7613.201027","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:04:50Z","timestamp":1716476690000},"page":"132-134","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Hydroxychloroquine-induced erythroderma"],"prefix":"10.4103","volume":"49","author":[{"given":"Sunil B.","family":"Pai","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhuvaneshwari","family":"Sudershan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kuruvilla","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kasturba Medical College Hospital, Manipal University, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Kamath","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja K.","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260528","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/rheumatology\/36.7.799","article-title":"Antimalarial drugs in the treatment of rheumatological diseases","volume":"36","author":"Rynes","year":"1997","journal-title":"Br J Rheumatol"},{"key":"R4-20260528","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"R5-20260528","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejim.2015.11.017","article-title":"Adverse drug reactions and organ damage: The skin","volume":"28","author":"Marzano","year":"2016","journal-title":"Eur J Intern Med"},{"key":"R6-20260528","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-5945-5-5","article-title":"Erythroderma: A clinical study of 97 cases","volume":"5","author":"Akhyani","year":"2005","journal-title":"BMC Dermatol"},{"key":"R7-20260528","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3315\/jdcr.2016.1222","article-title":"Erythroderma. A clinical and etiological study of 103 patients","volume":"10","author":"C\u00e9sar","year":"2016","journal-title":"J Dermatol Case Rep"},{"key":"R8-20260528","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4103\/2229-5178.126024","article-title":"Clinico-etiological study of 30 erythroderma cases from tertiary center in South India","volume":"5","author":"Hulmani","year":"2014","journal-title":"Indian Dermatol Online J"},{"issue":"5 Pt 1","key":"R9-20260528","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0190-9622(85)70108-9","article-title":"Plaquenil-induced erythroderma","volume":"12","author":"Slagel","year":"1985","journal-title":"J Am Acad Dermatol"},{"key":"R10-20260528","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1001\/archderm.138.9.1231","article-title":"Adverse cutaneous reactions to hydroxychloroquine are more common in patients with dermatomyositis than in patients with cutaneous lupus erythematosus","volume":"138","author":"Pelle","year":"2002","journal-title":"Arch Dermatol"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363791-201749010-00028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:41:35Z","timestamp":1787769695000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363791-201749010-00028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/0253-7613.201027","relation":{},"ISSN":["0253-7613","1998-3751"],"issn-type":[{"value":"0253-7613","type":"print"},{"value":"1998-3751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2016-08-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}