{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:30:08Z","timestamp":1787758208174,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>\n                    To study the antidiarrheal activity of the decoction of\n                    <jats:italic toggle=\"yes\">Cyperus rotundus<\/jats:italic>\n                    Linn. tubers using representative assays of diarrheal pathogenesis and understand its mechanism of action.Antibacterial, antigiardial and antirotaviral activities were studied. Effect on adherence of enteropathogenic\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    (EPEC) and invasion of enteroinvasive\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    (EIEC) and\n                    <jats:italic toggle=\"yes\">Shigella flexneri<\/jats:italic>\n                    to HEp-2 cells was evaluated as a measure of effect on colonization. Effect on enterotoxins such as enterotoxigenic\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    (ETEC) heat labile toxin (LT), heat stable toxin (ST) and cholera toxin (CT) was also assessed. The decoction showed antigiardial activity, reduced bacterial adherence to and invasion of HEp-2 cells and affected production of CT and action of LT. The decoction of\n                    <jats:italic toggle=\"yes\">C. rotundus<\/jats:italic>\n                    does not have marked antimicrobial activity and exerts its antidiarrheal action by mechanisms other than direct killing of the pathogen.\n                  <\/jats:p>","DOI":"10.4103\/0253-7613.81502","type":"journal-article","created":{"date-parts":[[2011,5,28]],"date-time":"2011-05-28T10:05:28Z","timestamp":1306577128000},"page":"340-344","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":34,"title":["Studies on the activity of Cyperus rotundus Linn. tubers against infectious diarrhea"],"prefix":"10.4103","volume":"43","author":[{"given":"Poonam G.","family":"Daswani","sequence":"first","affiliation":[{"name":"The Foundation for Medical Research, Worli, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Brijesh","sequence":"additional","affiliation":[{"name":"The Foundation for Medical Research, Worli, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pundarikakshudu","family":"Tetali","sequence":"additional","affiliation":[{"name":"Naoroji Godrej Centre for Plant Research, Lawkin Ltd. Campus, Shirwal, Satara, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tannaz J.","family":"Birdi","sequence":"additional","affiliation":[{"name":"The Foundation for Medical Research, Worli, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260605","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0140-6736(96)07492-2","article-title":"Alternative projections of mortality and disability by cause 1990-2020: Global burden of disease study","volume":"349","author":"Murray","year":"1997","journal-title":"Lancet"},{"key":"R3-20260605","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1172\/JCI34005","article-title":"Enteric infections, diarrhea, and their impact on function and development","volume":"18","author":"Petri","year":"2008","journal-title":"J Clin Invest"},{"key":"R4-20260605","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1136\/gut.2003.022103","article-title":"Management of infectious diarrhoea","volume":"53","author":"Casburn-Jones","year":"2004","journal-title":"Gut"},{"key":"R5-20260605","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.5897\/AJB2007.000-2465","article-title":"Antidiarrhoeal activity of different plants used in traditional medicine","volume":"6","author":"Gutierrez","year":"2007","journal-title":"Afr J Biotechnol"},{"key":"R7-20260605","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1472-6882-9-47","article-title":"Studies on the antidiarrhoeal activity of Aegle marmelos unripe fruit: Validating its traditional usage","volume":"9","author":"Brijesh","year":"2009","journal-title":"BMC Complement Altern Med"},{"key":"R8-20260605","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1472-6882-10-33","article-title":"Newer insights into the mechanism of action of Psidium guajava L.leaves in infectious diarrhoea","volume":"10","author":"Birdi","year":"2010","journal-title":"BMC Complement Altern Med"},{"key":"R10-20260605","first-page":"20","article-title":"Review on Cyperus rotundus \u2013 A potential herb","volume":"2","author":"Meena","year":"2010","journal-title":"International Journal of Pharmaceutical and Clinical Research"},{"key":"R11-20260605","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/IJPHA_2001332_116","article-title":"Study of the action of Cyperus rotundus root decoction on the adherence and enterotoxin production of diarrhoeagenic Escherichia coli","volume":"33","author":"Daswani","year":"2001","journal-title":"Indian J Pharmacol"},{"key":"R12-20260605","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.fitote.2004.11.011","article-title":"Antidiarrhoeal activity of Cyperus rotundus","volume":"77","author":"Uddin","year":"2006","journal-title":"Fitoterapia"},{"key":"R13-20260605","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jep.2003.09.042","article-title":"Effect of a polyherbal formulation on experimental models of inflammatory bowel diseases","volume":"90","author":"Jagtap","year":"2004","journal-title":"J Ethnopharmacol"},{"key":"R14-20260605","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jep.2007.08.043","article-title":"Anti-inflammatory compounds from leaves and bark of Alchornea cordifolia (Schumach. and Thonn.) 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