{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:23:27Z","timestamp":1787844207627,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To evaluate ethanolic extract of leaves of\n                      <jats:italic toggle=\"yes\">Aegle marmelos<\/jats:italic>\n                      in an experimental animal model of chronic fatigue syndrome for potential therapeutic benefit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Age\/weight-matched female Wistar albino rats were grouped into five groups. (Group I- V) (n = 8). Group I served as na\u00efve control and II served as stress control. Except for group I animals, other group animals were subjected to forced swimming every day for 15 minutes to induce a state of chronic fatigue and simultaneously treated with ethanolic extract of\n                      <jats:italic toggle=\"yes\">Aegle marmelos<\/jats:italic>\n                      (EEAM) 150 and 250 mg\/kg b.w. and Imipramine (20 mg.kg b.w.), respectively. Duration of immobility, anxiety level and locomotor activity were assessed on day 1, 7, 14 and 21 followed by biochemical estimation of oxidative biomarkers at the end of the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Treatment with EEAM (150 and 250 mg\/kg b.w.) resulted in a statistically significant and dose dependent reduction (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) in the duration of immobility, reduction in anxiety and increase in locomotor activity. Dose dependent and significant reduction in LPO level and increase in CAT and SOD was observed in extract treated animals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The results are suggestive of potential protective effect of\n                      <jats:italic toggle=\"yes\">A. marmelos<\/jats:italic>\n                      against experimentally induced CFS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0253-7613.96316","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T14:28:31Z","timestamp":1337264911000},"page":"351-356","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of protective effect of Aegle marmelos Corr. in an animal model of chronic fatigue 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