{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:23:06Z","timestamp":1787844186406,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To study anti-ulcer effect of Amlodipine and compared it with ranitidine in indomethacin, alcohol and pyloric ligation-induced gastric ulcers in wistar rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Gastric ulcers were induced in Wistar albino rats by oral administration of indomethacin (200 mg\/kg), alcohol (80%, 1 ml\/100 gm) and by pyloric ligation. Antiulcer activity of amlodipine (0.5 mg\/kg, i.p.) was observed either alone or in combination with ranitidine (15 mg\/kg, i.p.), on ulcer index, gastric pH and gastric volume. Statistical analysis was done by ANOVA and unpaired one tailed \u2018\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      \u2018 test.\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Amlodipine produced significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05) decrease in ulcer index and gastric pH as compared to control. It also produced significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05) increase in gastric volume as compared to ranitidine. The anti-ulcer effects of ranitidine were significantly higher than that of amlodipine. Combination of amlodipine and ranitidine did not show significant increase in anti-ulcer activity as compared with ranitidine alone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Amlodipine produced significant anti-ulcer effects in all 3 experimental models. Amlodipine increased the volume of gastric secretions as compared to ranitidine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0253-7613.96344","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T14:28:31Z","timestamp":1337264911000},"page":"387-389","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of anti-ulcer effect of amlodipine in gastric ulcer models in rats"],"prefix":"10.4103","volume":"44","author":[{"given":"Amol N.","family":"Patil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari G.","family":"Advani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. N.","family":"Mali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir","family":"Pawar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanket B.","family":"Raut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R3-20-20260529","first-page":"G342","article-title":"Cytoprotective effect of centrally administered neurotensin on stress-induced gastric ulcers","volume":"242","author":"Nemeroff","year":"1982","journal-title":"Am J Physiol"},{"key":"R4-20-20260529","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4103\/0253-7613.28206","article-title":"Antiulcer effect of Amlodipine and its interaction with H2 blocker and proton pump inhibitor in pylorus ligated rats","volume":"38","author":"Bhave","year":"2006","journal-title":"Indian J Pharmacol"},{"key":"R5-20-20260529","first-page":"29","article-title":"Gastric antiulcer activity of calcium channel blockers in rats","volume":"26","author":"Jain","year":"1994","journal-title":"Indian J Pharmacol"},{"key":"R6-20-20260529","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1248\/jhs.52.781","article-title":"Dose dependent effects of Verapamil on ethanol-induced gastric lesions in rats","volume":"52","author":"Kilic","year":"2006","journal-title":"J Health Sci"},{"key":"R8-20-20260529","first-page":"120","article-title":"Review of current methodology of evaluation of gastric and duodenal antiulcer agents","volume":"25","author":"Parmar","year":"1993","journal-title":"Indian J Pharmacol"},{"key":"R9-20-20260529","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0014-2999(85)90787-3","article-title":"The influence of verapamil on the gastric effects of stress in rats","volume":"112","author":"Ogle","year":"1985","journal-title":"Eur J Pharmacol"},{"key":"R10-20-20260529","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0002-9149(99)00362-8","article-title":"Amlodipine promotes kinin-mediated nitric oxide production in coronary microvessels of failing human hearts","volume":"84","author":"Zhang","year":"1999","journal-title":"Am J Cardiol"},{"key":"R11-20-20260529","first-page":"48","article-title":"[The epidemiological aspects of combined arterial hypertension and peptic ulcer] ;62:48-50","volume":"62","author":"Smirnov","year":"1990","journal-title":"Ter Arkh"},{"key":"R12-20-20260529","first-page":"1005","article-title":"Peptic ulcer disease","volume":"76","author":"Ramakrishnan","year":"2007","journal-title":"Am Fam Physician"},{"key":"R13-20-20260529","doi-asserted-by":"crossref","first-page":"701","DOI":"10.2165\/00002512-200320090-00006","article-title":"NSAID and aspirin use by the elderly in general practice: effect on gastrointestinal symptoms and therapies","volume":"20","author":"Pilotto","year":"2003","journal-title":"Drugs Aging"},{"key":"R14-20-20260529","first-page":"273","article-title":"The influence of calcium antagonists (verapamil, nifedipine, and MgCl2) on rat gastric damage induced by ethanol in vivo and in vitro","volume":"44","author":"Ostrowski","year":"1993","journal-title":"J Physiol Pharmacol"},{"key":"R15-20-20260529","first-page":"390","article-title":"Potentiation of gastric antiulcer effect of famotidine by calcium channel blockers in rats","volume":"30","author":"Mandal","year":"1998","journal-title":"Indian J Pharmacol"}],"container-title":["Indian Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363791-201244030-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:13:43Z","timestamp":1787843623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363791-201244030-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.4103\/0253-7613.96344","relation":{},"ISSN":["0253-7613"],"issn-type":[{"value":"0253-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}