{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:41:37Z","timestamp":1786653697803,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,2]]},"abstract":"\n Purpose:<\/jats:title>\n To compare the outcome of Collagen cross-linking (CXL) with that following topography-guided customized ablation treatment (T-CAT) with simultaneous CXL in eyes with progressive keratoconus.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n This was a prospective, non-randomized single centre study of 66 eyes with progressive keratoconus. Of these, 40 eyes underwent CXL and 26 eyes underwent T-CAT + CXL. The refractive, topographic, tomographic and aberrometric changes measured at baseline, 1, 3 and 6 months post-operatively were compared between both groups.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n After a mean follow-up of 7.7 \u00b1 1.3 months, the mean retinoscopic cylinder decreased by 1.02 \u00b1 3.16 D in the CXL group (\n P<\/jats:italic>\n = 0.1) and 2.87 \u00b1 3.22 D in the T-CAT + CXL group (\n P<\/jats:italic>\n = 0.04). The Best corrected visual acuity increased by 2 lines or more in 10% of eyes in the CXL group and in 23.3% of eyes in the T-CAT + CXL group. The mean steepest-K reduced by 0.40 \u00b1 3.71 D (\n P<\/jats:italic>\n = 0.77) in the CXL group and by 2.91 \u00b1 2.01D (\n P<\/jats:italic>\n = 0.03) in the T-CAT + CXL group. The sag factor and surface asymmetry index showed no significant change in the CXL group but reduced by 3.59 \u00b1 5.94 D (\n P<\/jats:italic>\n = 0.01) and 0.72 \u00b1 1.18 (\n P<\/jats:italic>\n = 0.02) respectively in the T-CAT + CXL group. There was a significant increase in the highest posterior corneal elevation in both groups (9.57 \u00b1 14.93 \u03bc in the CXL group and 7.85 \u00b1 9.25 \u03bc in the T-CAT + CXL group,\n P<\/jats:italic>\n \u2264 0.001 for both). There was significantly greater reduction of mean coma (\n P<\/jats:italic>\n < 0.001) and mean higher-order aberrations (\n P<\/jats:italic>\n = 0.01) following T-CAT + CXL compared to CXL.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n CAT + CXL is an effective approach to confer biomechanical stability and to improve the corneal contour in eyes with keratoconus and results in better refractive, topographic and aberrometric outcomes than CXL alone.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0301-4738.111209","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T02:30:25Z","timestamp":1391049025000},"page":"229-235","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Corneal changes following collagen cross linking and simultaneous topography guided photoablation with collagen cross linking for keratoconus"],"prefix":"10.4103","volume":"62","author":[{"given":"Prema","family":"Padmanabhan","sequence":"first","affiliation":[{"name":"Department of Cornea and Refractive Surgery, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwaryah","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Cornea and Refractive Surgery, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abinaya Priya","family":"Venkataraman","sequence":"additional","affiliation":[{"name":"Department of Cornea and Refractive Surgery, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cornea and Refractive Surgery, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Cornea and Refractive Surgery, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251008","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"Wollensak","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"R2-20251008","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jcrs.2006.01.091","article-title":"Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: Preliminary refractive results in an Italian study","volume":"32","author":"Caporossi","year":"2006","journal-title":"J Cataract Refract Surg"},{"key":"R3-20251008","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jcrs.2007.12.039","article-title":"Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: Long-term results","volume":"34","author":"Raiskup-Wolf","year":"2008","journal-title":"J Cataract Refract Surg"},{"key":"R4-20251008","first-page":"S720","article-title":"A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: Preliminary results","volume":"24","author":"Wittig-Silva","year":"2008","journal-title":"J Refract Surg"},{"key":"R5-20251008","first-page":"813","article-title":"Corneal Cross-linking for the treatment of keratoconus: Preliminary results","volume":"71","author":"Jankov","year":"2008","journal-title":"Arq Bras Oftalmol"},{"key":"R6-20251008","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00347-008-1783-2","article-title":"Collagen cross-linking with riboflavin and UVA light in keratoconus. 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