{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:41:35Z","timestamp":1786653695236,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To report our experience of brachytherapy using \u2018BARC I-125 Ocu-Prosta seeds\u2019 for the management of intraocular tumors with regard to tumor control, globe preservation visual outcome, and patient survival at Sankara Nethralaya, Chennai, India between September 2003 and May 2011.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We reviewed records of 35 eyes of 35 patients who underwent ophthalmic brachytherapy between September 2003 and May 2011. Twenty-one cases had choroidal melanoma, nine had childhood retinoblastoma, two had adult-onset retinoblastoma, and there were one case each of vasoproliferative tumor, retinal angioma, and ciliary body melanoma. Brachytherapy was administered using a 15- or 20-mm gold plaque with or without a notch. Brachytherapy was the primary treatment modality in all tumors other than retinoblastoma, wherein brachytherapy was done post chemoreduction for residual tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>For choroidal melanomas, the mean radiation dose was 68.69 \u00b1 15.07 (range, 47.72-94.2) Gy. The eye salvage rate was 13\/20 (65%) and tumor control rate was 16\/20 (80%) at an average follow-up of 24.43 \u00b1 24.75 (range, 1.5-87.98) months. For retinoblastoma, the mean dose was 45.85 \u00b1 3.90 (range, 39.51-50.92) Gy. The eye salvage rate and tumor control rate was 5\/6 (83.3%) at an average follow-up of 38.36 \u00b1 31.33 (range, 4.14-97.78) months. All eyes with retinoblastoma needed additional focal therapy for tumor control and eye salvage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results of this retrospective study confirms that the use of \u2018BARC I-125 Ocu-Prosta seeds\u2019 in episcleral plaques to treat intraocular tumors offers a viable option for the management of intraocular cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0301-4738.128618","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T05:21:17Z","timestamp":1394515277000},"page":"158-162","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Brachytherapy of intra ocular tumors using \u2018BARC I-125 Ocu-Prosta seeds\u2019: An Indian experience"],"prefix":"10.4103","volume":"62","author":[{"given":"Vikas","family":"Khetan","sequence":"first","affiliation":[{"name":"Department of Ocular Oncology and Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingam","family":"Gopal","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology and Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India"},{"name":"Department of Ophthalmology, National University Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh P","family":"Shanmugam","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology and Vitreoretinal Services, Sankara Eye Hospitals, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology and Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology and Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod","family":"Bhende","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology and Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva","family":"Muthukumar","sequence":"additional","affiliation":[{"name":"Chief Medical Physicist, Dr. Rai Memorial Cancer Institute, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Consultant Radiation Oncologist, Dr. Rai Memorial Cancer Institute, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thayalan","family":"Kuppuswamy","sequence":"additional","affiliation":[{"name":"Consultant Medical Physicist, Dr. Kamakshi Memorial Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S K","family":"Saxena","sequence":"additional","affiliation":[{"name":"Radiopharmaceuticals Division, Bhabha Atomic Research Center, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Dash","sequence":"additional","affiliation":[{"name":"Radiopharmaceuticals Division, Bhabha Atomic Research Center, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251008","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0039-6257(97)00088-X","article-title":"Radiation therapy for choroidal melanoma","volume":"42","author":"Finger","year":"1997","journal-title":"Surv Ophthalmol"},{"key":"R2-20251008","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0161-6420(99)90456-6","article-title":"Comparison of episcleral plaque and proton beam radiation therapy for the treatment of choroidal melanoma","volume":"106","author":"Wilson","year":"1999","journal-title":"Ophthalmology"},{"key":"R3-20251008","first-page":"143","article-title":"Current concepts in the management of adult intraocular tumours","volume":"45","author":"Shanmugam","year":"1997","journal-title":"Indian J Ophthalmol"},{"key":"R4-20251008","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4103\/0301-4738.98708","article-title":"Episcleral plaque brachytherapy using \u2018BARC I-125 Ocu-Prosta seeds\u2019 in the treatment of intraocular tumors: A single-institution experience in India","volume":"60","author":"Shah","year":"2012","journal-title":"Indian J Ophthalmol"},{"key":"R5-20251008","first-page":"25","article-title":"AERB SS-3 (Rev-1). Testing and classification of sealed radioactive sources. A publication of Atomic Energy Regulatory Board of India","year":"2001"},{"key":"R6-20251008","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0969-8043(02)00099-4","article-title":"A novel approach for the adsorption of iodine-125 on silver wire as matrix for brachytherapy source for the treatment of eye and prostate cancer","volume":"57","author":"Mathew","year":"2002","journal-title":"Appl Radiat Isot"},{"key":"R7-20251008","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.apradiso.2005.08.011","article-title":"Studies on the production and quality assurance of miniature 125I radioactive sources suitable for treatment of ocular and prostate cancers","volume":"64","author":"Saxena","year":"2006","journal-title":"Appl Radiat Isot"},{"key":"R8-20251008","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S0360-3016(03)00006-3","article-title":"The American Brachytherapy Society recommendations for brachytherapy of uveal melanomas","volume":"56","author":"Nag","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R9-20251008","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/PL00007880","article-title":"Long-term follow-up of Ru-106\/Rh-106 brachytherapy for posterior uveal melanoma","volume":"238","author":"Lommatzsch","year":"2000","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R10-20251008","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.ajo.2003.12.032","article-title":"Survival, anatomic, and functional long-term results in choroidal and ciliary body melanoma after ruthenium brachytherapy (15 years\u2019 experience with beta-rays)","volume":"137","author":"Rouberol","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"R11-20251008","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.ophtha.2004.11.038","article-title":"Ruthenium brachytherapy for uveal melanoma, 1979-2003: Survival and functional outcomes in the Swedish population","volume":"112","author":"Bergman","year":"2005","journal-title":"Ophthalmology"},{"key":"R12-20251008","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1259\/0007-1285-49-582-551","article-title":"The treatment of ophthalmic tumours with lowenergy sources","volume":"49","author":"Sealy","year":"1976","journal-title":"Brj Radiol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223307-201462020-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:07Z","timestamp":1786650067000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223307-201462020-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0301-4738.128618","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"2012-09-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}