{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:21:06Z","timestamp":1792225266818,"version":"4.4.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>In this retrospective case series, we report the spectrum and outcomes of aggressive posterior retinopathy of prematurity (APROP) in infants \u22651500 g birth weight. Twenty-nine eyes of 15 infants are included. All infants were referred from level I or II nurseries, received supplemental unmonitored oxygen for prolonged duration (&gt;1 week) and had multiple systemic co-morbidities. Of the 29 eyes, 10 (34.5%) had zone 1 and 19 (65.5%) had posterior zone 2 disease. Twenty-five (86.2%) eyes had flat neovascularization and 4 (13.8%) eyes had brush like proliferation. We noticed large vascular loops in 10 (34.5%) eyes. After confluent laser photocoagulation, 22 (75.9%) eyes had a favorable outcome. The study concludes that APROP in heavier (\u22651500 g birth weight) premature infants occurs mostly in posterior zone 2 with flat neovascularization and atypical features like large vascular loops. Supplemental unmonitored oxygen for prolonged duration and multiple systemic co-morbidities could be a contributing factor.<\/jats:p>","DOI":"10.4103\/0301-4738.128639","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T05:21:17Z","timestamp":1394515277000},"page":"254-257","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":51,"title":["Aggressive posterior retinopathy of prematurity in infants \u22651500 g birth weight"],"prefix":"10.4103","volume":"62","author":[{"given":"Gaurav","family":"Sanghi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangat R","family":"Dogra","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeksha","family":"Katoch","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amod","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251008","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1001\/archopht.123.7.991","article-title":"International committee for the classification of retinopathy of prematurity. 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Levels of neonatal care","volume":"114","author":"Stark","year":"2004","journal-title":"Pediatrics"},{"key":"R9-20251008","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ajo.2006.05.048","article-title":"Early vitreous surgery for aggressive posterior retinopathy of prematurity","volume":"142","author":"Azuma","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"R10-20251008","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ajo.2006.02.018","article-title":"Retinopathy of prematurity: Two distinct mechanisms that underlie zone1 and zone 2 disease","volume":"142","author":"Flynn","year":"2006","journal-title":"Am J Ophthalmol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223307-201462020-00030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:05Z","timestamp":1786650065000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223307-201462020-00030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0301-4738.128639","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"2012-02-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}