{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:53:33Z","timestamp":1778698413161,"version":"3.51.4"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,5]]},"DOI":"10.4103\/0366-6999.235118","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T12:06:43Z","timestamp":1530014803000},"page":"1549-1556","source":"Crossref","is-referenced-by-count":20,"title":["A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia"],"prefix":"10.1097","volume":"131","author":[{"given":"Qing","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lie-Xin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-Quan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Song","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Hua","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-6-20210129","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.3748\/wjg.v23.i30.5589","article-title":"Efficacy and safety of Xiangsha Liujunzi granules for functional dyspepsia: A multi-center randomized double-blind placebo-controlled clinical study","volume":"23","author":"Lv","year":"2017","journal-title":"World J Gastroenterol"},{"key":"R2-6-20210129","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.3748\/wjg.14.6388","article-title":"Chronic gastrointestinal symptoms and quality of life in the Korean population","volume":"14","author":"Jeong","year":"2008","journal-title":"World J Gastroenterol"},{"key":"R3-6-20210129","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","article-title":"Functional gastroduodenal disorders","volume":"130","author":"Tack","year":"2006","journal-title":"Gastroenterology"},{"key":"R4-6-20210129","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1440-1746.2011.06633.x","article-title":"Current understanding of pathogenesis of functional dyspepsia","volume":"26","author":"Miwa","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"R5-6-20210129","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nrgastro.2013.11","article-title":"Current management strategies and emerging treatments for functional dyspepsia","volume":"10","author":"Camilleri","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"R6-6-20210129","first-page":"1028","article-title":"Efficacy of Qi-Zhi-Wei-Tong granules on dysmotility-like functional dyspepsia: An analysis of 48 cases","volume":"19","author":"Chen","year":"2010","journal-title":"J Emerg Tradit Chin Med"},{"key":"R7-6-20210129","first-page":"2930","article-title":"Efficacy of Qi-Zhi-Wei-Tong granules on dysmotility-like functional dyspepsia: An analysis of 58 cases (in Chinese)","volume":"15","author":"Wang","year":"2006","journal-title":"Modern J Integr Tradit Chin West Med"},{"key":"R8-6-20210129","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1053\/j.gastro.2006.03.008","article-title":"The functional gastrointestinal disorders and the Rome III process","volume":"130","author":"Drossman","year":"2006","journal-title":"Gastroenterology"},{"key":"R9-6-20210129","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/MPG.0b013e3181fea0a9","article-title":"Value of the likert dyspepsia scale in differentiation of functional and organic dyspepsia in children","volume":"52","author":"Canan","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"R10-6-20210129","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/2050640613510904","article-title":"Effect of lansoprazole on the epigastric symptoms of functional dyspepsia (ELF study): A multicentre, prospective, randomized, double-blind, placebo-controlled clinical trial","volume":"1","author":"Suzuki","year":"2013","journal-title":"United European Gastroenterol J"},{"key":"R11-6-20210129","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1056\/NEJMoa052639","article-title":"A placebo-controlled trial of itopride in functional dyspepsia","volume":"354","author":"Holtmann","year":"2006","journal-title":"N Engl J Med"},{"key":"R12-6-20210129","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/gut.37.1.47","article-title":"Does Helicobacter pylori infection increase gastric sensitivity in functional dyspepsia?","volume":"37","author":"Mearin","year":"1995","journal-title":"Gut"},{"key":"R13-6-20210129","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1023\/B:DDAS.0000026317.00071.75","article-title":"Clinical presentation and personality factors are predictors of the response to treatment in patients with functional dyspepsia; a randomized, double-blind placebo-controlled crossover study","volume":"49","author":"Holtmann","year":"2004","journal-title":"Dig Dis Sci"},{"key":"R14-6-20210129","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/BF03256924","article-title":"Itopride in the treatment of functional dyspepsia in Chinese patients: A prospective, multicentre, post-marketing observational study","volume":"31","author":"Sun","year":"2011","journal-title":"Clin Drug Investig"},{"key":"R15-6-20210129","doi-asserted-by":"crossref","first-page":"336","DOI":"10.11569\/wcjd.v17.i3.336","article-title":"Combined therapy of domperidone and compound digestive enzymes for functional dyspepsia: An analysis of 84 cases","volume":"17","author":"Zheng","year":"2009","journal-title":"World Chin J Digestol"},{"key":"R16-6-20210129","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archpsyc.1965.01720310065008","article-title":"A self-rating depression scale","volume":"12","author":"Zung","year":"1965","journal-title":"Arch Gen Psychiatry"},{"key":"R17-6-20210129","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0033-3182(71)71479-0","article-title":"A rating instrument for anxiety disorders","volume":"12","author":"Zung","year":"1971","journal-title":"Psychosomatics"},{"key":"R18-6-20210129","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1572-0241.1999.00781.x","article-title":"Placebo in functional dyspepsia: Symptomatic, gastrointestinal motor, and gastric sensorial responses","volume":"94","author":"Mearin","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"R19-6-20210129","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1046\/j.1365-2036.1998.00410.x","article-title":"Efficacy of omeprazole in functional dyspepsia: Double-blind, randomized, placebo-controlled trials (the bond and opera studies)","volume":"12","author":"Talley","year":"1998","journal-title":"Aliment Pharmacol Ther"},{"key":"R20-6-20210129","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0254-6272(13)60168-5","article-title":"Effect of herbal formula xiao pi-II on functional dyspepsia","volume":"33","author":"Liu","year":"2013","journal-title":"J Tradit Chin Med"},{"key":"R21-6-20210129","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000351086","article-title":"The Tibetan herbal formula padma digestin in functional dyspepsia: An open-label study","volume":"20","author":"Meier","year":"2013","journal-title":"Forsch Komplementmed"},{"key":"R22-6-20210129","first-page":"62","article-title":"Rikkunshito improves the symptoms in patients with functional dyspepsia, accompanied by an increase in the level of plasma ghrelin","volume":"59","author":"Arai","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"R23-6-20210129","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s11655-015-2175-5","article-title":"Dalitong granule combined with electroacupuncture in the treatment of functional dyspepsia: A randomized controlled trial","volume":"21","author":"Zhang","year":"2015","journal-title":"Chin J Integr Med"},{"key":"R24-6-20210129","doi-asserted-by":"crossref","first-page":"91S","DOI":"10.1016\/S0002-9343(99)00086-8","article-title":"Problems and challenges in the design of irritable bowel syndrome clinical trials: Experience from published trials","volume":"107","author":"Spiller","year":"1999","journal-title":"Am J Med"},{"key":"R25-6-20210129","first-page":"3242","article-title":"Symptom-based tendencies of Helicobacter pylori eradication in patients with functional dyspepsia","volume":"17","author":"Lan","year":"2011","journal-title":"World J Gastroenterol"},{"key":"R26-6-20210129","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1053\/j.gastro.2004.05.030","article-title":"Pathophysiology and treatment of functional dyspepsia","volume":"127","author":"Tack","year":"2004","journal-title":"Gastroenterology"},{"key":"R27-6-20210129","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/nmo.12718","article-title":"The relationship among gastroparetic symptoms, quality of life, and gastric emptying in patients referred for gastric emptying testing","volume":"28","author":"DiBaise","year":"2016","journal-title":"Neurogastroenterol Motil"},{"key":"R28-6-20210129","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1177\/0300060517726442","article-title":"Impaired vagal activity to meal in patients with functional dyspepsia and delayed gastric emptying","volume":"46","author":"Guo","year":"2018","journal-title":"J Int Med Res"},{"key":"R29-6-20210129","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1080\/003655201750305440","article-title":"Treatment of non-ulcer dyspepsia: A meta-analysis of placebo-controlled prospective studies","volume":"36","author":"Allescher","year":"2001","journal-title":"Scand J Gastroenterol"},{"key":"R30-6-20210129","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1751-2980.2011.00491.x","article-title":"Cisapride: What can we learn from the rise and fall of a prokinetic?","volume":"12","author":"Quigley","year":"2011","journal-title":"J Dig Dis"},{"key":"R31-6-20210129","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3109\/13880209.2013.854396","article-title":"The effects of Fructus Aurantii extract on the 5-hydroxytryptamine and vasoactive intestinal peptide contents of the rat gastrointestinal tract","volume":"52","author":"Jiang","year":"2014","journal-title":"Pharm Biol"},{"key":"R32-6-20210129","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1055\/s-0028-1088342","article-title":"Effect of constituents from Fructus Aurantii Immaturus and Radix Paeoniae Alba on gastrointestinal movement","volume":"75","author":"Fang","year":"2009","journal-title":"Planta Med"},{"key":"R33-6-20210129","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1440-1681.1996.tb01769.x","article-title":"Antihypertensive effects of DL-tetrahydropalmatine: An active principle isolated from corydalis","volume":"23","author":"Lin","year":"1996","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"R34-6-20210129","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jep.2016.05.024","article-title":"Multicomponent, multitarget integrated adjustment \u2013 Metabolomics study of Qizhiweitong particles curing gastrointestinal motility disorders in mice induced by atropine","volume":"189","author":"Chang","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"R35-6-20210129","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/nrgastro.2013.10","article-title":"The role of psychosocial factors and psychiatric disorders in functional dyspepsia","volume":"10","author":"Van Oudenhove","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"R36-6-20210129","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2036.2012.05128.x","article-title":"Review article: Current treatment options and management of functional dyspepsia","volume":"36","author":"Lacy","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"R37-6-20210129","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0278-5846(03)00108-8","article-title":"Anxiolytic-like action of orally administered dl-tetrahydropalmatine in elevated plus-maze","volume":"27","author":"Leung","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"R38-6-20210129","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3940(01)01962-0","article-title":"DL-tetrahydropalmatine may act through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats","volume":"307","author":"Chang","year":"2001","journal-title":"Neurosci Lett"}],"container-title":["Chinese Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/0366-6999.235118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T19:48:06Z","timestamp":1623959286000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00029330-201807050-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":38,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/0366-6999.235118","relation":{},"ISSN":["0366-6999"],"issn-type":[{"value":"0366-6999","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,5]]}}}