{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:32Z","timestamp":1787841332115,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Bacterial isolates from intra-abdominal infections, in particular, peritonitis and their unpredictable antimicrobial resistance patterns, continue to be a matter of concern not only globally but regionally too.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>An attempt in the present study was made to study the patterns of drug resistance in bacterial isolates, especially gram negative bacilli in intra-abdominal infections (IAI) in our hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>From 100 cases of peritonitis, identification of isolates was done as per recommended methods. Antimicrobial susceptibility and extended-spectrum beta-lactamase (ESBL) testing were performed following the CLSI guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 133 clinical isolates were obtained, of which 108 were aerobes and 22 anaerobes. Fungal isolates were recovered in only three cases.\n                      <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                      (47\/108) emerged as the most predominant pathogen followed by\n                      <jats:italic toggle=\"yes\">Klebsiella spp.<\/jats:italic>\n                      (27\/108), while\n                      <jats:italic toggle=\"yes\">Bacteroides fragilis<\/jats:italic>\n                      emerged as the predominant anaerobe (12\/22). Among coliforms, 61.7%\n                      <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                      and 74.1%\n                      <jats:italic toggle=\"yes\">Klebsiella spp.<\/jats:italic>\n                      were ESBL positive. A high level of resistance was observed for beta lactams, ciprofloxacin, amikacin, and ertapenem. Ertapenem resistance (30-41%) seen in coliforms, appears as an important issue. Imipenem, tigecycline, and colistin were the most consistently active agents tested against ESBL producers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Drug resistance continues to be a major concern in isolates from intra-abdominal infections. Treatment with appropriate antibiotics preceded by antimicrobial resistance testing aided by early diagnosis, adequate surgical management, and knowledge of antibiotic - resistant organisms appears effective in reducing morbidity and mortality in IAI cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0377-4929.125321","type":"journal-article","created":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T01:32:10Z","timestamp":1390008730000},"page":"388-392","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Bacterial profile and patterns of antimicrobial drug resistance in intra-abdominal infections: Current experience in a teaching hospital"],"prefix":"10.4103","volume":"56","author":[{"given":"Neetu","family":"Shree","sequence":"first","affiliation":[{"name":"Department of Microbiology, Vardhman Mahavir Medical College & Safdarjang Hospital, New Delhi, 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