{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:42Z","timestamp":1787841342480,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Neurofibromatosis (NF-1) patients have an increased risk of developing malignancies most commonly rhabdomyosarcomas, optic gliomas, brain tumors and non-lymphocytic leukemias. Acute lymphoblastic leukemia (ALL) has been infrequently reported in association with NF-1. We describe a rare association of NF-1, T-lineage ALL and parvovirus infection in a 12-year-old child. In addition, it is also to emphasize that a high index of suspicion should be kept for parvovirus B19 infection as a cause of bicytopenia\/pancytopenia in ALL patients following induction chemotherapy.<\/jats:p>","DOI":"10.4103\/0377-4929.125366","type":"journal-article","created":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T01:32:10Z","timestamp":1390008730000},"page":"446-448","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["T-lineage acute lymphoblastic leukemia and parvovirus infection in a child with neurofibromastosis-1"],"prefix":"10.4103","volume":"56","author":[{"given":"Pallavi","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Pathology, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shano","family":"Naseem","sequence":"additional","affiliation":[{"name":"Department of Hematology, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Varma","sequence":"additional","affiliation":[{"name":"Department of Hematology, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RK","family":"Marwaha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250920","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/bjc.1994.431","article-title":"Neurofibromatosis and childhood leukaemia\/lymphoma: A population-based UKCCSG study","volume":"70","author":"Stiller","year":"1994","journal-title":"Br J Cancer"},{"key":"R2-20250920","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0022-3476(78)80362-X","article-title":"Neurofibromatosis and childhood leukemia","volume":"92","author":"Bader","year":"1978","journal-title":"J Pediatr"},{"key":"R3-20250920","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s00380-004-0786-4","article-title":"Fatal eosinophilic heart disease in a child with neurofibromatosis-1 complicated by acute lymphoblastic leukemia","volume":"20","author":"Horigome","year":"2005","journal-title":"Heart Vessels"},{"key":"R4-20250920","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.humpath.2008.09.003","article-title":"Gaucher or pseudo-Gaucher? The challenge of several diseases colliding in a pediatric patient","volume":"40","author":"Cajaiba","year":"2009","journal-title":"Hum Pathol"},{"key":"R5-20250920","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1182\/blood-2007-06-095075","article-title":"Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis","volume":"111","author":"Balgobind","year":"2008","journal-title":"Blood"},{"key":"R6-20250920","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1056\/NEJM199403033300903","article-title":"Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders","volume":"330","author":"Shannon","year":"1994","journal-title":"N Engl J Med"},{"key":"R7-20250920","doi-asserted-by":"crossref","first-page":"603","DOI":"10.4103\/0377-4929.85109","article-title":"Parvovirus B19 presenting with persistent pancytopenia in a patient of T-ALL post induction chemotherapy diagnosed on bone marrow examination","volume":"54","author":"Gadage","year":"2011","journal-title":"Indian J Pathol Microbiol"},{"key":"R8-20250920","first-page":"407","article-title":"A pilot study on parvovirus B19 infection in paediatric haematological malignancies","volume":"133","author":"Kishore","year":"2011","journal-title":"Indian J Med Res"},{"key":"R9-20250920","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/00043426-200206000-00009","article-title":"Serologic study on parvovirus b19 infection in childhood acute lymphoblastic leukemia during chemotherapy: Clinical and hematologic implications","volume":"24","author":"Heegaard","year":"2002","journal-title":"J Pediatr Hematol Oncol"},{"key":"R10-20250920","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1086\/526522","article-title":"Parvovirus B19 infection in children with acute lymphoblastic leukemia is associated with cytopenia resulting in prolonged interruptions of chemotherapy","volume":"46","author":"Lindblom","year":"2008","journal-title":"Clin Infect Dis"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00004270-201356040-00028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:50:22Z","timestamp":1787838622000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00004270-201356040-00028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.4103\/0377-4929.125366","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}