{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:42:50Z","timestamp":1787071370643,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>\n                      C-reactive protein (CRP) is an acute phase reactant, widely used as a biomarker for various infectious and inflammatory conditions. Guillain-Barr\u03b9 syndrome (GBS) is an acute, autoimmune, polyradiculoneuropathy, triggered by infectious agents such as\n                      <jats:italic toggle=\"yes\">Campylobacter jejuni<\/jats:italic>\n                      . GBS is generally precipitated 1-3 weeks following\n                      <jats:italic toggle=\"yes\">C. jejuni<\/jats:italic>\n                      infection which suggests a humoral immunopathogenic mechanism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>Basal CRP levels were estimated in sera of patients with GBS and compared with adequate controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings &amp; Design:<\/jats:title>\n                    <jats:p>The study population was divided into 4 groups: (i) GBS group included 45 newly diagnosed GBS patients; (ii) Neurological control (NC) group comprised of 59 patients with non-paralytic neurological symptoms\/disorders; (iii) Non-neurological controls (NNC) comprised of 43 patients having no neurological symptoms and (iv) Healthy controls (HC) comprised of 101 healthy subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>CRP was evaluated using slide latex agglutination test (LAT) and enzyme linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>Statistical analysis was done by the Chi-square test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>CRP by LAT was positive in 24.4% GBS group, 34% NC group and 44% NNC group. The range of titer in CRP positive samples in the three patient groups (GBS, NC, NNC) was at concentration of 0.6 mg\/dl to 19.2 mg\/dl. Similar results were also obtained by ELISA in the patient groups. None of the HC subjects was positive for detectable levels of CRP. High basal level of CRP was detected in patients with GBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Autoimmune conditions like GBS can stimulate the production of a high level of inflammation resulting in an increase in the CRP production.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0377-4929.130897","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T09:02:49Z","timestamp":1398675769000},"page":"51-54","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["C-reactive protein in patients with Guillain Barr\u00e9 syndrome"],"prefix":"10.4103","volume":"57","author":[{"given":"Chetana","family":"Vaishnavi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 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