{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:42:27Z","timestamp":1787071347452,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    Goblet cell carcinoid (GCC) is a rare variant of carcinoid tumor that exclusively involves the appendix. It usually occurs in 5\n                    <jats:sup>th<\/jats:sup>\n                    -6\n                    <jats:sup>th<\/jats:sup>\n                    decade with the most common clinical presentation being acute appendicitis. The natural history of this tumor is intermediate between carcinoids and adenocarcinomas. We here report a case of GCC diagnosed incidentally in a patient presenting with acute intestinal obstruction. Ultrasonographic examination supported the clinical diagnosis of acute intestinal obstruction, following which the patient underwent laparotomy and resection of ileum along with appendix was done. On gross pathological examination, a nodular growth was present on the tip and body of appendix that was yellow in color with a semi-solid to mucoid consistency on cut section. On microscopy, lakes of mucin with few acinar structures floating in them were seen. The submucosa as well as serosa were infiltrated by clusters of goblet cells and well-formed acini, with little atypia. Glands and nests were positive for per-iodic acid Schiff and immunohistochemistry showed focal chromogranin positivity in glandular structures, thereby confirming the diagnosis of GCC. Although the prognosis of GCC is better than adenocarcinomas, it is one of the carcinoids having a poorer outcome when compared with other variants of carcinoid tumor. Therefore, it is important to rule out other differential diagnoses of goblet cell carcinoid, the most important being mucinous adenocarcinomas.\n                  <\/jats:p>","DOI":"10.4103\/0377-4929.130918","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T09:02:49Z","timestamp":1398675769000},"page":"120-123","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Incidentally discovered goblet cell carcinoid clinically presenting as acute intestinal obstruction: A case report with review of literature"],"prefix":"10.4103","volume":"57","author":[{"given":"Nishat","family":"Afroz","sequence":"first","affiliation":[{"name":"Department of Pathology, J N Medical College, AMU, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nida","family":"Shamim","sequence":"additional","affiliation":[{"name":"Department of Pathology, J N Medical College, AMU, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lateef Ahmed","family":"Sofi","sequence":"additional","affiliation":[{"name":"Department of Pathology, J N Medical College, AMU, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Amjad Ali","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, J N Medical College, AMU, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250922","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/cncr.10589","article-title":"Primary malignant neoplasms of the appendix: A population-based study from the surveillance, epidemiology and end-results program, 1973-1998","volume":"94","author":"McCusker","year":"2002","journal-title":"Cancer"},{"key":"R2-20250922","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1097\/01.MP.0000097362.10330.B1","article-title":"Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors","volume":"16","author":"Stancu","year":"2003","journal-title":"Mod Pathol"},{"key":"R3-20250922","first-page":"386","article-title":"Crypt cell carcinoma of the appendix","volume":"18","author":"Gallegos","year":"1992","journal-title":"Eur J Surg Oncol"},{"key":"R4-20250922","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/dc.2840070211","article-title":"Goblet-cell carcinoid tumor in peritoneal fluid: A case report","volume":"7","author":"Wojcik","year":"1991","journal-title":"Diagn Cytopathol"},{"key":"R5-20250922","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0002-9610(05)80145-X","article-title":"Goblet cell carcinoid of the appendix","volume":"168","author":"Butler","year":"1994","journal-title":"Am J Surg"},{"key":"R6-20250922","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/ajcp\/94.1.27","article-title":"Goblet cell carcinoids and related tumors of the vermiform appendix","volume":"94","author":"Burke","year":"1990","journal-title":"Am J Clin Pathol"},{"key":"R7-20250922","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF02556796","article-title":"Adenocarcinoid of the vermiform appendix. A clinicopathologic study of 20 cases","volume":"31","author":"Bak","year":"1988","journal-title":"Dis Colon Rectum"},{"key":"R8-20250922","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1097\/PAS.0b013e31817f1816","article-title":"Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix","volume":"32","author":"Tang","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"R9-20250922","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2559.1991.tb00815.x","article-title":"Appendiceal goblet cell carcinoids: A clinicopathological and immunohistochemical study","volume":"18","author":"Anderson","year":"1991","journal-title":"Histopathology"},{"key":"R10-20250922","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4251\/wjgo.v2.i6.251","article-title":"Goblet cell carcinoid tumors of the appendix: An overview","volume":"2","author":"Roy","year":"2010","journal-title":"World J Gastrointest Oncol"},{"key":"R11-20250922","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1245\/ASO.2006.02.016","article-title":"Surgical and chemotherapy treatment outcomes of goblet cell carcinoid: A tertiary cancer center experience","volume":"13","author":"Pham","year":"2006","journal-title":"Ann Surg Oncol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00004270-201457010-00029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:43Z","timestamp":1787067883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00004270-201457010-00029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0377-4929.130918","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}