{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:42:27Z","timestamp":1787071347214,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Skin is one of the important organs affected by amyloidosis which is characterized by extracellular deposition of fibrillary proteins having homogenous, eosinophilic on routine staining with distinct tinctorial properties. Nodular cutaneous amyloidosis is rare and may affect dermis, subcutis and also vascular walls. Nodular amyloid deposits in the deeper dermis occurring at the site of insulin injection are a rare observation, which is described here. This description indicates that cutaneous amyloidosis may be associated with local subcutaneous injections of insulin and may clinically mimic a neoplasm or lipodystrophic lesion.<\/jats:p>","DOI":"10.4103\/0377-4929.130920","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T09:02:49Z","timestamp":1398675769000},"page":"127-129","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Cutaneous amyloidosis at the site of insulin injection with coexistence of acanthosis nigricans"],"prefix":"10.4103","volume":"57","author":[{"given":"Bevinahalli N.","family":"Nandeesh","sequence":"first","affiliation":[{"name":"Department of Pathology, St. John\u2032s Medical College, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Rajalakshmi","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. John\u2032s Medical College, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Shubha","sequence":"additional","affiliation":[{"name":"Department of Dermatology, St. John\u2032s Medical College, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250922","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF00276849","article-title":"Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient","volume":"31","author":"Dische","year":"1988","journal-title":"Diabetologia"},{"key":"R2-20250922","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.diabres.2006.07.013","article-title":"Severe insulin resistance associated with subcutaneous amyloid deposition","volume":"75","author":"Albert","year":"2007","journal-title":"Diabetes Res Clin Pract"},{"key":"R3-20250922","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0190-9622(98)70069-6","article-title":"Cutaneous deposition diseases","volume":"39","author":"Touart","year":"1998","journal-title":"Part I. J Am Acad Dermatol"},{"key":"R4-20250922","first-page":"138","article-title":"Human recombinant insulin and amyloidosis: An unexpected association","volume":"68","author":"Sie","year":"2010","journal-title":"Neth J Med"},{"key":"R5-20250922","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.humpath.2009.02.019","article-title":"Localized insulin-derived amyloidosis in patients with diabetes mellitus: A case report","volume":"40","author":"Yumlu","year":"2009","journal-title":"Hum Pathol"},{"key":"R6-20250922","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2230.2012.04373.x","article-title":"Coexistence of insulin-derived amyloidosis and an overlying acanthosis nigricans-like lesion at the site of insulin injection","volume":"38","author":"Kudo-Watanuki","year":"2013","journal-title":"Clin Exp Dermatol"},{"key":"R7-20250922","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0140-6736(09)60041-6","article-title":"The insulin ball","volume":"373","author":"Nagase","year":"2009","journal-title":"Lancet"},{"key":"R8-20250922","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1046\/j.1464-5491.2002.07581.x","article-title":"Examination of insulin injection sites: An unexpected finding of localized amyloidosis","volume":"19","author":"Swift","year":"2002","journal-title":"Diabet Med"},{"key":"R9-20250922","doi-asserted-by":"crossref","first-page":"29691","DOI":"10.1074\/jbc.M705004200","article-title":"Investigation into the role of macrophages in the formation and degradation of beta2-microglobulin amyloid fibrils","volume":"282","author":"Morten","year":"2007","journal-title":"J Biol Chem"},{"key":"R10-20250922","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbapap.2003.12.008","article-title":"Conformational constraints for amyloid fibrillation: The importance of being unfolded","volume":"1698","author":"Uversky","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"R11-20250922","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2169\/internalmedicine.49.2633","article-title":"Localized amyloidosis at the site of repeated insulin injection in a diabetic patient","volume":"49","author":"Shikama","year":"2010","journal-title":"Intern Med"},{"key":"R12-20250922","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.1016\/j.jaad.2010.03.001","article-title":"Nodular amyloidosis in a diabetic patient with frequent hypoglycemia: Sequelae of repeatedly injecting insulin without site rotation","volume":"63","author":"Endo","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"R13-20250922","doi-asserted-by":"crossref","DOI":"10.3949\/ccjm.75.11.772","article-title":"Skin manifestations of diabetes","volume":"75","author":"Van Hattem","year":"2008","journal-title":"Cleve Clin J Med"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00004270-201457010-00031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:43Z","timestamp":1787067883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00004270-201457010-00031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0377-4929.130920","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}