{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:51:48Z","timestamp":1786636308591,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Pathol Microbiol"],"published-print":{"date-parts":[[2010]]},"DOI":"10.4103\/0377-4929.59173","type":"journal-article","created":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T02:25:55Z","timestamp":1263954355000},"page":"1","source":"Crossref","is-referenced-by-count":9,"title":["Immunohistochemical study of p16\n                    <sup>INK4A<\/sup>\n                    and survivin expressions in cervical squamous neoplasm"],"prefix":"10.4103","volume":"53","author":[{"given":"GeokChin","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydee","family":"Norlatiffah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NAkmal","family":"Sharifah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazali","family":"Razmin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MSidik","family":"Shiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AZailani","family":"Hatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HOon","family":"Paul-Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0377-4929.59173-1","unstructured":"Yahya H and Lim G. Second Report of the National Cancer Registry Cancer Incidence in Malaysia: Ministry of Health Malaysia. 2003"},{"key":"key-10.4103\/0377-4929.59173-2","first-page":"154","volume-title":"2001 Consensus Guidelines for the Management of Women with Cervical Intraepithelial Neoplasia","author":"Wright","year":"2003","journal-title":"J Low Genit Tract Dis"},{"key":"key-10.4103\/0377-4929.59173-3","first-page":"544","volume-title":"Cervical screening adjuncts: recent advances","author":"Spitzer","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"key-10.4103\/0377-4929.59173-4","first-page":"190","volume-title":"p16 INK4a immunoexpression: surrogate marker of high-risk HPV and high-grade cervical intraepithelial neoplasia","author":"Kalof","year":"2006","journal-title":"Adv Anat Pathol"},{"key":"key-10.4103\/0377-4929.59173-5","first-page":"113","volume-title":"Survivin, a novel anti-apoptosis inhibitor, expression in uterine cervical cancer and relationship with prognostic factors","author":"Lee","year":"2005","journal-title":"Int J Gynecol Cancer"},{"key":"key-10.4103\/0377-4929.59173-6","first-page":"287","volume-title":"Effects of human papillomavirus type 16 oncoproteins on survivin gene expression","author":"Borb\u00e9ly","year":"2006","journal-title":"J Gen Virol"},{"key":"key-10.4103\/0377-4929.59173-7","first-page":"665","volume-title":"p 16(INK4a) expression correlates with degree of cervical neoplasia: a comparison with Ki-67 expression and detection of high-risk HPV types","author":"Agoff","year":"2003","journal-title":"Mod Pathol"},{"key":"key-10.4103\/0377-4929.59173-8","first-page":"276","volume-title":"Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri","author":"Klaes","year":"2001","journal-title":"Int J Cancer"},{"key":"key-10.4103\/0377-4929.59173-9","first-page":"1741","volume-title":"Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions","author":"Sano","year":"1998","journal-title":"Am J Pathol"},{"key":"key-10.4103\/0377-4929.59173-10","first-page":"144","volume-title":"P16 INK4a Immunocytochemistry as a Triage Test for Liquid-based Cervicovaginal Cytology Samples Diagnosed as High-Grade Squamous Intrepithelial Lesions","author":"Jovanovic","year":"2005","journal-title":"Pathology Case Reviews"},{"key":"key-10.4103\/0377-4929.59173-11","first-page":"57","volume-title":"Taxonomic classification of papillomaviruses","author":"de","year":"2001","journal-title":"Papillomavirus Report"},{"key":"key-10.4103\/0377-4929.59173-12","first-page":"7874","volume-title":"The human papillomavirus E6 protein and its contribution to malignant progression","author":"Mantovani","year":"2001","journal-title":"Oncogene"},{"key":"key-10.4103\/0377-4929.59173-13","first-page":"73","volume-title":"Human papillomavirus DNA and genotypes: prognostic factors for progression of cervical intraepithelial neoplasia","author":"Gaarenstroom","year":"1994","journal-title":"Int J Gynecol Cancer"},{"key":"key-10.4103\/0377-4929.59173-14","first-page":"7888","volume-title":"Biological activities and molecular targets of the human papillomavirus E7 oncoprotein","author":"M\u00fcnger","year":"2001","journal-title":"Oncogene"},{"key":"key-10.4103\/0377-4929.59173-15","first-page":"6622","volume-title":"The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle","author":"Flores","year":"2000","journal-title":"J Virol"},{"key":"key-10.4103\/0377-4929.59173-16","doi-asserted-by":"crossref","unstructured":"Tommasino M. Early genes of human papillomaviruses. Encyclopedic reference of cancer. Springer-Verlag 2001. p. 266-72.","DOI":"10.1007\/3-540-30683-8_477"},{"key":"key-10.4103\/0377-4929.59173-17","first-page":"4705","volume-title":"Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16 INK4a -imposed G1 cell cycle Arrest","author":"Giarr\u00e8","year":"2001","journal-title":"J Virol"},{"key":"key-10.4103\/0377-4929.59173-18","first-page":"354","volume-title":"p16(INK4A) expression is related to grade of cin and high-risk human papillomavirus but does not predict virus clearance after conization or disease outcome","author":"Branca","year":"2004","journal-title":"Int J Gynecol Pathol"},{"key":"key-10.4103\/0377-4929.59173-19","first-page":"525","volume-title":"p16 INK4A , CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer","author":"Murphy","year":"2005","journal-title":"J Clin Pathol"},{"key":"key-10.4103\/0377-4929.59173-20","first-page":"267","volume-title":"Human papillomavirus genotyping and p16 INK4a expression in cervical intraepithelial neoplasia of adolescents","author":"Hu","year":"2005","journal-title":"Mod Pathol"},{"key":"key-10.4103\/0377-4929.59173-21","first-page":"580","volume-title":"Control of apoptosis and mitotic spindle checkpoint by survivin","author":"Li","year":"1998","journal-title":"Nature"},{"key":"key-10.4103\/0377-4929.59173-22","first-page":"795","volume-title":"The utility of p16 (Ink4a) in discriminating between cervical intraepithelial neoplasia 1 and nonneoplastic equivocal lesions of the cervix","author":"Redman","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"key-10.4103\/0377-4929.59173-23","unstructured":"Cruez AF. Malaysian youth are involved in sexual activities before the age of 20- Lekhraj Rampal New Straits Times: Press Holding Ltd. Co.,2007"},{"key":"key-10.4103\/0377-4929.59173-24","first-page":"347","volume-title":"Overexpression of p16 INK4a as an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia","author":"Ishikawa","year":"2006","journal-title":"Int J Gynecol Cancer"},{"key":"key-10.4103\/0377-4929.59173-25","first-page":"186","volume-title":"Natural history of cervical intraepithelial neoplasia: a critical review","author":"Ost\u00f6r","year":"1993","journal-title":"Int J Gynecol Pathol"},{"key":"key-10.4103\/0377-4929.59173-26","first-page":"561","volume-title":"A population-based five-year follow-up study of cervical human papillomavirus infection","author":"Elfgren","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"key-10.4103\/0377-4929.59173-27","first-page":"396","volume-title":"Persistence and load of high-risk HPV are predictors for development of high-grade cervical lesions: a longitudinal French cohort study","author":"Dalstein","year":"2003","journal-title":"Int J Cancer"},{"key":"key-10.4103\/0377-4929.59173-28","first-page":"3106","volume-title":"Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia","author":"Schlecht","year":"2001","journal-title":"JAMA"},{"key":"key-10.4103\/0377-4929.59173-29","doi-asserted-by":"crossref","unstructured":"Nieh S, Chen SF, Chu TY, Lai HC, Lin YS, Fu E, et al. Is p16(INK4A) expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorized Pap smear? A comparative analysis using abnormal cervical smears with follow-up biopsies. Gynecol Oncol 2005;97:35-40.","DOI":"10.1016\/j.ygyno.2004.11.034"},{"key":"key-10.4103\/0377-4929.59173-30","first-page":"109","volume-title":"Evidence for at least three alternative mechanisms targeting the p16 INK4A \/cyclin D\/Rb pathway in penile carcinoma, one of which is mediated by high-risk human papillomavirus","author":"Ferreux","year":"2003","journal-title":"J Pathol"},{"key":"key-10.4103\/0377-4929.59173-31","doi-asserted-by":"crossref","unstructured":"Branca M, Giorgi C, Santini D, Di Bonito L, Ciotti M, Costa S, et al. HPV-Pathogen ISS Study Group. Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer. Am J Clin Pathol 2005;124:113-21","DOI":"10.1309\/L8BWF431WU9AC8FJ"},{"key":"key-10.4103\/0377-4929.59173-32","first-page":"865","volume-title":"Staining characteristics of p16 INK4a : is there a correlation with lesion grade or high-risk human papilloma virus positivity?","author":"Ozgul","year":"2008","journal-title":"J Obstet Gynaecol Res"},{"key":"key-10.4103\/0377-4929.59173-33","first-page":"137","volume-title":"Analysis of Bcl-2, Bax and Survivin genes in uterine cancer","author":"Saitoh","year":"1999","journal-title":"Int J Oncol"},{"key":"key-10.4103\/0377-4929.59173-34","first-page":"415","volume-title":"Communication: expression of the novel inhibitor of apoptosis survivin in normal and neoplastic skin","author":"Chiodino","year":"1999","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/0377-4929.59173-35","first-page":"738","volume-title":"Immunohistochemical localization of survivin in benign cervical mucosa, cervical dysplasia, and invasive squamous cell carcinoma","author":"Frost","year":"2002","journal-title":"Am J Clin Pathol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:55:54Z","timestamp":1786632954000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0377-4929.59173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010]]}},"alternative-id":["59173"],"URL":"https:\/\/doi.org\/10.4103\/0377-4929.59173","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}