{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:42:21Z","timestamp":1787071341008,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>Poorly differentiated synovial sarcoma is a diagnostically challenging neoplasm. Most commonly they occur in the soft tissue of the extremities and are rare in the mediastinum. They can be indistinguishable from other \u201cround cell tumors\u201d based on the morphology alone or at times by immunohistochemical studies. Here in, we report an extremely rare case of metastatic poorly differentiated monophasic synovial sarcoma of the mediastinum without a known primary in a 30-year-old man. The imaging studies on admission showed 10 \u00d7 9.5 cm anterior mediastinal mass with multiple nodules in the lung and pleura along with multiple enlarged mediastinal and axillary lymph nodes. Histopathologic and immunohistochemical analysis supported the diagnosis of poorly differentiated synovial sarcoma, which was further confirmed by molecular genetic analysis.<\/jats:p>","DOI":"10.4103\/0377-4929.81650","type":"journal-article","created":{"date-parts":[[2011,5,28]],"date-time":"2011-05-28T10:08:01Z","timestamp":1306577281000},"page":"384-387","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Poorly differentiated monophasic synovial sarcoma of the mediastinum"],"prefix":"10.4103","volume":"54","author":[{"given":"Maha","family":"Arafah","sequence":"first","affiliation":[{"name":"Division of Histopathology, King Saud University, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaesta N","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Division of Histopathology, King Saud University, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250922","first-page":"573","article-title":"Exstirpation einer sehr grossen, mit dicken Stiele angewachsenen Kneigelenkmaus mit gluklichem Erfolge","volume":"6","author":"Simon","year":"1865","journal-title":"Arch Klin Chir"},{"key":"R2-20250922","first-page":"754","article-title":"Synovial sarcomes","volume":"55","author":"Sabrazes","year":"1934","journal-title":"Gaz Hebd Sc Med Bordeaux"},{"key":"R3-20250922","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.5858\/2006-130-1199-MDOS","article-title":"Molecular diagnosis of sarcomas: Chromosomal translocations in sarcomas","volume":"130","author":"Lazar","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"R4-20250922","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0003-4975(01)03110-1","article-title":"Mediastinal synovial sarcoma: Report of two cases with molecular genetic analysis","volume":"73","author":"Trupiano","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"R5-20250922","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0022-5223(98)70333-2","article-title":"Primary sarcomas of the mediastinum: Results of therapy","volume":"115","author":"Burt","year":"1998","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R6-20250922","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1073\/pnas.84.7.1981","article-title":"Involvement of chromosome X in primary cytogenetic change in human neoplasia: Nonrandom translocation in synovial sarcoma","volume":"84","author":"Turc-Carel","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"R7-20250922","first-page":"217","article-title":"Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown primary: A molecular genetic analysis","volume":"3","author":"Rong","year":"2009","journal-title":"Int J Clin Exp Pathol"},{"key":"R8-20250922","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1038\/sj.onc.1204601","article-title":"Fusions of the SYT and SSX genes in synovial sarcoma","volume":"20","author":"Ladanyi","year":"2001","journal-title":"Oncogene"},{"key":"R9-20250922","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1092-9134(98)80042-7","article-title":"Synovial sarcoma","volume":"2","author":"Fisher","year":"1998","journal-title":"Ann Diagn Pathol"},{"key":"R10-20250922","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1586\/era.09.64","article-title":"New medical treatment options and strategies to assess clinical outcome in soft-tissue sarcoma","volume":"9","author":"Schmitt","year":"2009","journal-title":"Expert Rev Anticancer Ther"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00004270-201154020-00032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:39Z","timestamp":1787067879000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00004270-201154020-00032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.4103\/0377-4929.81650","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}