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Cortexolone 17a-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0.05% cream. 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United States Patent US 2013\/0039921 A1. Available from: https:\/\/www.google.com\/patents. [Last accessed on 2016 Jan 02]"},{"key":"key-10.4103\/0378-6323.199581-100","first-page":"3112","volume-title":"Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity","author":"Sader","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.4103\/0378-6323.199581-101","first-page":"31","volume-title":"Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates","author":"Faccone","year":"2014","journal-title":"Eur J Med Chem"},{"key":"key-10.4103\/0378-6323.199581-102","first-page":"1386","volume-title":"Quality control guidelines for MIC susceptibility testing of omiganan pentahydrochloride (MBI 226), a novel antimicrobial peptide","author":"Anderegg","year":"2004","journal-title":"J Clin Microbiol"},{"key":"key-10.4103\/0378-6323.199581-103","first-page":"314","volume-title":"Vitamin C in disease prevention and cure: An overview","author":"Chambial","year":"2013","journal-title":"Indian J Clin Biochem"},{"key":"key-10.4103\/0378-6323.199581-104","first-page":"171","volume-title":"Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris","author":"Klock","year":"2005","journal-title":"Int J Cosmet Sci"},{"key":"key-10.4103\/0378-6323.199581-105","first-page":"22","volume-title":"Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: A randomized, double-blind, controlled trial","author":"Woolery-Lloyd","year":"2010","journal-title":"J Cosmet Dermatol"},{"key":"key-10.4103\/0378-6323.199581-106","unstructured":"Apremilast in the Treatment of Moderate to Severe Acne. Identifier NCT01074502. Clinical Trials: A Service of the U.S National Institutes of Health. Available from: http:\/\/www.clinicaltrials.gov. [Last accessed on 2016 Jan 02]."},{"key":"key-10.4103\/0378-6323.199581-107","first-page":"49","volume-title":"XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1\u03b2-mediated diseases","author":"Owyang","year":"2011","journal-title":"MAbs"},{"key":"key-10.4103\/0378-6323.199581-108","first-page":"1","volume-title":"Which are the antibodies to watch in 2013?","author":"Reichert","year":"2013","journal-title":"MAbs"},{"key":"key-10.4103\/0378-6323.199581-109","first-page":"327","volume-title":"Expression of inflammatory biomarkers from cultured sebocytes was influenced by treatment with Vitamin D","author":"Lee","year":"2013","journal-title":"Indian J Dermatol","ISSN":"https:\/\/id.crossref.org\/issn\/0019-5154","issn-type":"print"},{"key":"key-10.4103\/0378-6323.199581-110","first-page":"645898","volume-title":"The effect of calcipotriol on the expression of human beta defensin-2 and LL-37 in cultured human keratinocytes","author":"Kim","year":"2009","journal-title":"Clin Dev Immunol"},{"key":"key-10.4103\/0378-6323.199581-111","first-page":"1080","volume-title":"Vitamin D induces the antimicrobial protein hCAP18 in human skin","author":"Weber","year":"2005","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/0378-6323.199581-112","first-page":"221","volume-title":"Dapsone 5% gel: A review of its efficacy and safety in the treatment of acne vulgaris","author":"Stotland","year":"2009","journal-title":"Am J Clin Dermatol"},{"key":"key-10.4103\/0378-6323.199581-113","first-page":"123","volume-title":"Superiority of a combined contraceptive containing drospirenone to a triphasic preparation containing norgestimate in acne treatment","author":"Thorneycroft","year":"2004","journal-title":"Cutis"},{"key":"key-10.4103\/0378-6323.199581-114","first-page":"23","volume-title":"Treating acne with oral contraceptives: Use of lower doses","author":"Huber","year":"2006","journal-title":"Contraception"},{"key":"key-10.4103\/0378-6323.199581-115","first-page":"169","volume-title":"Hormonal therapy in dermatology","author":"Shaw","year":"2001","journal-title":"Dermatol Clin"},{"key":"key-10.4103\/0378-6323.199581-116","first-page":"429","volume-title":"Immunotherapy for acne vulgaris: Current status and future directions","author":"Simonart","year":"2013","journal-title":"Am J Clin Dermatol"}],"container-title":["Indian Journal of Dermatology, Venereology and Leprology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T05:43:59Z","timestamp":1611899039000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijdvl.com\/update-on-etiopathogenesis-and-treatment-of-acne\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":116,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017]]}},"alternative-id":["199581"],"URL":"https:\/\/doi.org\/10.4103\/0378-6323.199581","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727317034.793576538","asserted-by":"object"}]},"ISSN":["0378-6323"],"issn-type":[{"value":"0378-6323","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]}}}