{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:30:10Z","timestamp":1782552610111,"version":"3.54.5"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T00:00:00Z","timestamp":1577750400000},"content-version":"vor","delay-in-days":2921,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Plast Surg"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Background: The frequency of encountering radiodermatitis caused by X-ray fluoroscopic procedures for ischaemic heart disease is increasing. In severe cases, devastating ulcers with pain, for which conservative therapy is ineffective, emerge. Radiation-induced ulcers are notorious for being difficult to treat. Simple skin grafting often fails because of the poor state of the wound bed. A vascularized flap is a very good option. However, the non-adherence of the well-vascularized flap with the irradiated wound bed is frequently experienced. Aim: To ameliorate the irradiated wound bed, bone marrow-derived platelet-rich plasma (bm-PRP) was delivered during the surgery. Materials and Methods: Four patients with severe cutaneous radiation injury accompanied by unbearable pain after multiple fluoroscopic procedures for ischaemic heart disease were treated. Wide excision of the lesion and coverage with a skin flap supplemented with bm-PRP injection was performed. Results: All patients obtained wound closure and were relieved from pain. No complication concerning the bone marrow aspiration and delivery of bm-PRP was observed. Conclusions: Supplementation of bm-PRP can be an option without major complications, time, and cost to improve the surgical outcome for irradiated wounds.<\/jats:p>","DOI":"10.4103\/0970-0358.96599","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T15:34:29Z","timestamp":1337873669000},"page":"109-114","source":"Crossref","is-referenced-by-count":14,"title":["Supplementation of bone marrow aspirate-derived platelet-rich plasma for treating radiation-induced ulcer after cardiac fluoroscopic procedures: A preliminary report"],"prefix":"10.1055","volume":"45","author":[{"given":"Soh","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Tsumano","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Kakibuchi","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,12,31]]},"reference":[{"key":"key-10.4103\/0970-0358.96599-1","first-page":"510","volume-title":"Treatment of chronic wounds with bone marrow-derived cells","author":"Badiavas","year":"2003","journal-title":"Arch Dermatol"},{"key":"key-10.4103\/0970-0358.96599-2","first-page":"260","volume-title":"Platelet-rich plasma combined with skin substitute for chronic wound healing: A case report","author":"Knox","year":"2006","journal-title":"J Extra Corpor Technol"},{"key":"key-10.4103\/0970-0358.96599-3","first-page":"68","volume-title":"A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers","author":"Driver","year":"2006","journal-title":"Ostomy Wound Manage"},{"key":"key-10.4103\/0970-0358.96599-4","first-page":"307","volume-title":"Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: A comparative study","author":"Saad","year":"2011","journal-title":"Int Wound J"},{"key":"key-10.4103\/0970-0358.96599-5","first-page":"156","volume-title":"Simultaneous concentration of platelets and marrow cells: A simple and useful technique to obtain source cells and growth factors for regenerative medicine","author":"Nishimoto","year":"2007","journal-title":"Wound Repair Regen"},{"key":"key-10.4103\/0970-0358.96599-6","first-page":"695","volume-title":"Radiation injury to skin following fluoroscopically guided procedures","author":"Malkinson","year":"1996","journal-title":"Arch Dermatol"},{"key":"key-10.4103\/0970-0358.96599-7","first-page":"663","volume-title":"Chronic radiodermatitis following cardiac catheterization.Arch 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Transplant"},{"key":"key-10.4103\/0970-0358.96599-11","first-page":"141","volume-title":"Intracoronary autologous bone-marrow cell transfer after myocardial infarction: The BOOST randomised controlled clinical trial","author":"Wollert","year":"2004","journal-title":"Lancet"},{"key":"key-10.4103\/0970-0358.96599-12","first-page":"785","volume-title":"New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy","author":"Lataillade","year":"2007","journal-title":"Regen Med"},{"key":"key-10.4103\/0970-0358.96599-13","first-page":"50","volume-title":"Emerging therapy for improving wound repair of severe radiation burns using local bone marrow-derived stem cell administrations","author":"Bey","year":"2010","journal-title":"Wound Repair Regen"},{"key":"key-10.4103\/0970-0358.96599-14","first-page":"401","volume-title":"Preliminary results of a pilot study of pentoxifylline in the treatment of late radiation soft tissue necrosis","author":"Dion","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key-10.4103\/0970-0358.96599-15","first-page":"1855","volume-title":"Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice","author":"Gupta","year":"2007","journal-title":"J Immunol"},{"key":"key-10.4103\/0970-0358.96599-16","first-page":"1122","volume-title":"Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease","author":"Aslam","year":"2009","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Indian Journal of Plastic 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