{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:32:39Z","timestamp":1791091959602,"version":"4.1.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and Objective:<\/jats:title>\n                    <jats:p>To determine the effects of Primary Hyperparathyroidism on oral cavity in a symptomatic contemporary Indian population by taking note of the following parameters: (1) Radiological alteration of lamina dura, (2) mandibular cortical width, (3) prevalence of brown tumor, and (4) mandibular tori.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>\n                      Twenty-six patients of Primary Hyperparathyroidism were examined clinically and radiologically for extra- and intraoral abnormalities. Loss of lamina dura, mandibular cortical width, presence of mandibular tori, and brown tumors were assessed and correlated with serum Calcium, Phosphate, Parathormone, and Alkaline phosphatase. The results were compared with twenty-six age- and gender-matched control subjects. The data was expressed as mean \u00b1 SD, and a probability (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      ) value of &lt; 0.05 was considered significant. Pearson's statistical method was used to assess the significant correlation between radiological measurements and biochemical values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Generalized absence of the lamina dura was the most consistent finding and there was a significant correlation between its loss and altered parathormone, alkaline phosphatase, and inorganic phosphate, but not with serum calcium or the duration of the disease. Mean values (in mm) for the cortical indices were significantly lower in the patients compared to the controls and correlated significantly with parathormone and alkaline phosphatase. None of the patients had mandibular tori and only one patient had a brown tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Loss of lamina dura, ground glass appearance, and mandibular cortical width reduction are common findings in primary hyperparathyroidism and these are significantly correlated with elevated parathormone and alkaline phosphatase. However, the presence of brown tumors and oral tori are less commonly encountered features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0970-9290.102236","type":"journal-article","created":{"date-parts":[[2012,10,10]],"date-time":"2012-10-10T19:42:42Z","timestamp":1349898162000},"page":"384-387","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Oro-mandibular manifestations of primary hyperparathyroidism"],"prefix":"10.4103","volume":"23","author":[{"given":"Sachin","family":"Rai","sequence":"first","affiliation":[{"name":"Oral Health Sciences Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay K","family":"Bhadada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Rattan","sequence":"additional","affiliation":[{"name":"Oral Health Sciences Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Bhansali","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D S","family":"Rao","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Laboratory, Henry Ford Hospital, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viral","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260302","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/00060793-200312000-00002","article-title":"Treatment of primary hyperparathyroidism","volume":"10","author":"Rao","year":"2003","journal-title":"Curr Opin Endocrinol Diabetes"},{"key":"R3-20260302","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.otc.2004.02.004","article-title":"Primary, secondary, and tertiary hyperparathyroidism","volume":"37","author":"Ahmad","year":"2004","journal-title":"Otolaryngol Clin North Am"},{"key":"R4-20260302","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0030-4220(53)90115-7","article-title":"Roentgenologic manifestations of systemic disease in dentistry","volume":"6","author":"Stafne","year":"1953","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R5-20260302","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1210\/jc.2005-2282","article-title":"The impact of primary hyperthyroidism on the oral cavity","volume":"9","author":"Padbury","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R6-20260302","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0901-5027(00)80079-X","article-title":"Highly aggressive brown tumour of the maxilla as first manifestation of primary hyperparathyroidism","volume":"29","author":"Martinez-Gavidia","year":"2000","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R7-20260302","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.tripleo.2004.01.015","article-title":"Primary hyperparathyroidism presenting as a palatal brown tumor","volume":"98","author":"Daniels","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R8-20260302","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.dmfr.4600215","article-title":"Panoramic mandibular index as a radiomorphometric tool: A study in precision","volume":"26","author":"Ledgerton","year":"1997","journal-title":"Dentomaxillofac Radiol"},{"key":"R9-20260302","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0030-4220(82)90473-X","article-title":"Radiographic interpretation of the mandibular angular cortex: A diagnostic tool in metabolic bone loss, Part I: Normal bone","volume":"53","author":"Bras","year":"1982","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R10-20260302","first-page":"84","article-title":"Hyperparathyroidism: A review of 220 proven cases, with special emphasis on findings in the jaws","volume":"15","author":"Rosenberg","year":"1962","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R11-20260302","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/0030-4220(62)90375-4","article-title":"The dental structures in Primary Hyperparathyroidism","volume":"15","author":"Silverman","year":"1962","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R12-20260302","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1001\/jama.1961.03040450011003","article-title":"Clinical and laboratory aspects of the diagnosis of Primary Hyperparathyroidism","volume":"178","author":"Keating","year":"1961","journal-title":"J Am Med Assoc"},{"key":"R13-20260302","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-0528.1988.tb00557.x","article-title":"Prevalence of torus palatinus and torus mandibularis in Germans and Thai","volume":"16","author":"Reichart","year":"1988","journal-title":"Community Dent Oral Epidemiol"},{"key":"R14-20260302","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00276-007-0184-6","article-title":"Prevalence and clinical characteristics of oral tori in 1,520 Chulalongkorn University Dental School patients","volume":"29","author":"Jainkittivong","year":"2007","journal-title":"Surg Radiol Anat"},{"key":"R15-20260302","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s00276-005-0003-x","article-title":"Prevalence of torus palatinus in Turkish Schoolchildren","volume":"27","author":"Yildiz","year":"2005","journal-title":"Surg Radiol Anat"}],"container-title":["Indian Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363779-201223030-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:43:48Z","timestamp":1787773428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363779-201223030-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.4103\/0970-9290.102236","relation":{},"ISSN":["0970-9290","1998-3603"],"issn-type":[{"value":"0970-9290","type":"print"},{"value":"1998-3603","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"2010-11-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-08-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}