{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:18Z","timestamp":1787775858966,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objective:<\/jats:title>\n                    <jats:p>Oral submucous fibrosis (OSMF) is a well-known premalignant condition encountered in Indian population. Although the disease is advancing rapidly, its reliable treatment modality for its various stages has not yet evolved.<\/jats:p>\n                    <jats:p>The aim of the present study is to compare the effect of newer antioxidant lycopene with a placebo in conjunction with the cessation of causative habit in the treatment of OSMF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      The study group included 92 patients with OSMF. The OSMF diagnosis was established through a composite of accepted clinical and histopathological characteristics. Out of 92, 46 patients were given lycopene and remaining 46 were on placebo drug. Lycopene group patients received 8 mg Lycored\n                      <jats:sup>TM<\/jats:sup>\n                      per day in two divided doses of 4 mg each, while placebo group patients received placebo tablet twice a day. Patients were examined for changes in mouth opening and other clinical symptoms of OSMF during three months and were followed up for next two months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Lycopene was found to be significantly efficacious in the amelioration of signs and symptoms of OSMF. It was effective in reducing the objective signs of OSMF as demonstrated by the improved maximal mouth opening, percentage of which was 69.56%(\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation and Conclusion:<\/jats:title>\n                    <jats:p>Reactive oxygen compounds or free radicals have been implicated as one of the major harmful factors for premalignant and malignant conditions. Present study concludes that lycopene, a newer antioxidant, appears to be a very promising drug in the management of OSMF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0970-9290.104964","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T07:21:56Z","timestamp":1355988116000},"page":"524-528","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":43,"title":["Evaluation of the effect of newer antioxidant lycopene in the treatment of oral submucous fibrosis"],"prefix":"10.4103","volume":"23","author":[{"given":"Tapasya Vaibhav","family":"Karemore","sequence":"first","affiliation":[{"name":"Department of Oral Med. and Radio, V.S.P.M. Dental College, Hingna, Nagpur, Sharad Pawar Dental College, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukta","family":"Motwani","sequence":"additional","affiliation":[{"name":"Department of Oral Med. and Radio, V.S.P.M. Dental College, Hingna, Nagpur, Sharad Pawar Dental College, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260302","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0901-5027(05)80473-4","article-title":"Oral submucous fibrosis: A new concept in surgical management Report of 100 cases","volume":"24","author":"Khanna","year":"1995","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R2-20260302","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0901-5027(96)80058-0","article-title":"Application of the buccal pad of fat to the surgical treatment of oral submucous fibrosis","volume":"25","author":"Yeh","year":"1996","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R3-20260302","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/jnci\/91.4.317","article-title":"Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature","volume":"91","author":"Giovannucci","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"R4-20260302","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0271-5317(98)00193-6","article-title":"Role of Lycopene as antioxidant carotenoid in the prevention of chronic diseases: A review","volume":"19","author":"Rao","year":"1999","journal-title":"Nutr Res"},{"key":"R5-20260302","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1368-8375(99)00050-0","article-title":"Tomatoes, tomato rich foods, Lycopene and cancer of the upper aerodigestive tract: A case control in Uruguay","volume":"36","author":"De Stefani","year":"2000","journal-title":"Oral Oncol"},{"key":"R6-20260302","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1046\/j.1523-5408.2002.00004.x","article-title":"The role of carotenoids in human health","volume":"5","author":"Johnson","year":"2002","journal-title":"Nutr Clin Care"},{"key":"R7-20260302","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1177\/153537020222701013","article-title":"Overview of Mechanisms of Action of Lycopene","volume":"227","author":"Heber","year":"2002","journal-title":"Exp Biol Med"},{"key":"R8-20260302","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.oraloncology.2003.12.011","article-title":"Efficacy of oral lycopene in the treatment of oral leukoplakia","volume":"40","author":"Singh","year":"2004","journal-title":"Oral Oncol"},{"key":"R9-20260302","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.tripleo.2006.11.012","article-title":"Efficacy of lycopene in the management of oral submucous fibrosis","volume":"103","author":"Kumar","year":"2007","journal-title":"Oral sur Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R10-20260302","first-page":"181","article-title":"The effects of placenta extract in management of oral submucous fibrosis","volume":"24","author":"Khataria","year":"1992","journal-title":"Indian J Pharmacol"},{"key":"R11-20260302","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1600-0714.2005.00325.x","article-title":"Molecular pathogenesis of oral submucous fibrosis - a collagen metabolic disorder","volume":"34","author":"Rajlalitha","year":"2005","journal-title":"J Oral Pathol Med"},{"key":"R12-20260302","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/01635589709514499","article-title":"Evaluation of Multiple Micronutrient Supplementation in the Management of Oral Submucous Fibrosis in Karachi, Pakistan","volume":"27","author":"Maher","year":"1997","journal-title":"Nutr Cancer"},{"key":"R13-20260302","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/0278-2391(91)90002-4","article-title":"Management of Oral Submucous Fibrosis: A Conservative Approach","volume":"49","author":"Borle","year":"1991","journal-title":"J Oral Maxillofac Surg"},{"key":"R14-20260302","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/sj.bdj.4805876","article-title":"Oral submucous fibrosis: Its pathogenesis and management","volume":"160","author":"Canniff","year":"1986","journal-title":"Br Dent J"},{"key":"R15-20260302","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S1368-8375(02)00123-9","article-title":"The upregulation of type one plasminogen activator inhibitor in oral submucous fibrosis","volume":"39","author":"Shun","year":"2003","journal-title":"Oral Oncol"},{"key":"R16-20260302","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1034\/j.1600-0714.2001.301007.x","article-title":"Oral administration of milk from cows immunized with human intestinal bacteria leads to significant improvements of symptoms and signs in patients with oral submucous fibrosis","volume":"30","author":"Tai","year":"2001","journal-title":"J Oral Pathol Med"}],"container-title":["Indian Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363779-201223040-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:43:57Z","timestamp":1787773437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363779-201223040-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.4103\/0970-9290.104964","relation":{},"ISSN":["0970-9290","1998-3603"],"issn-type":[{"value":"0970-9290","type":"print"},{"value":"1998-3603","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"2010-03-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-01-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}