{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:31:27Z","timestamp":1786717887499,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Dent Res"],"published-print":{"date-parts":[[2016]]},"DOI":"10.4103\/0970-9290.186230","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:11:46Z","timestamp":1468887106000},"page":"283","source":"Crossref","is-referenced-by-count":3,"title":["Indirect immunofluorescence technique to study expression of toll-like receptor 4 in chronic periodontitis"],"prefix":"10.4103","volume":"27","author":[{"given":"RomaldinS","family":"Dsouza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KishoreG","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Sailaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayak","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0970-9290.186230-1","first-page":"33","volume-title":"A prospective experimental comparative study on the clinical effects of calculus dissolution based oral rinse in gingivitis patients","author":"Saini","year":"2015","journal-title":"Int J Exp Dent Sci"},{"key":"key-10.4103\/0970-9290.186230-2","first-page":"602","volume-title":", Foster BL, Barros SP, Darveau RP, Somerman MJ.Cementoblast gene expression is regulated by Porphyromonas gingivalis lipopolysaccharide partially via toll-like receptor-4\/MD-2","author":"Nociti","year":"2004","journal-title":"J Dent Res"},{"key":"key-10.4103\/0970-9290.186230-3","first-page":"592","volume-title":"Interleukin-17 and interleukin-18 levels in saliva and plasma of patients with chronic periodontitis","author":"Oz\u00e7aka","year":"2011","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0970-9290.186230-4","first-page":"73","volume-title":"Microbial recognition by Toll-like receptors","author":"Takeda","year":"2004","journal-title":"J Dermatol Sci"},{"key":"key-10.4103\/0970-9290.186230-5","first-page":"3","volume-title":"TLR signaling pathways","author":"Takeda","year":"2004","journal-title":"Semin Immunol"},{"key":"key-10.4103\/0970-9290.186230-6","first-page":"394","volume-title":"A human homologue of the Drosophila toll protein signals activation of adaptive immunity","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"key-10.4103\/0970-9290.186230-7","first-page":"257","volume-title":"Inferences, questions and possibilities in Toll-like receptor signalling","author":"Beutler","year":"2004","journal-title":"Nature"},{"key":"key-10.4103\/0970-9290.186230-8","first-page":"41","volume-title":"Toll-like receptors and their role in periodontal health and disease","author":"Mahanonda","year":"2000","journal-title":"Periodontol"},{"key":"key-10.4103\/0970-9290.186230-9","first-page":"2018","volume-title":"Bacterial lipopolysaccharide and IFN-\u03b3 induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: Role of NF-kB activation","author":"Faure","year":"2001","journal-title":"J Immunol"},{"key":"key-10.4103\/0970-9290.186230-10","first-page":"474","volume-title":"Differential expression of Toll-like receptor 2 in human cells","author":"Flo","year":"2001","journal-title":"J Leukoc Biol"},{"key":"key-10.4103\/0970-9290.186230-11","first-page":"1","volume-title":"Cutting edge: Recognition of gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2","author":"Yoshimura","year":"1999","journal-title":"J Immunol"},{"key":"key-10.4103\/0970-9290.186230-12","first-page":"286","volume-title":"Extolling the diversity of bacterial endotoxins","author":"Golenbock","year":"2001","journal-title":"Nat Immunol"},{"key":"key-10.4103\/0970-9290.186230-13","first-page":"20","volume-title":"TLR4: Central component of the sole mammalian LPS sensor","author":"Beutler","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"key-10.4103\/0970-9290.186230-14","first-page":"11058","volume-title":"Bacterial lipopolysaccharide activates NF-kB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells.Differential expression of TLR-4 and TLR-2 in endothelial cells","author":"Faure","year":"2000","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0970-9290.186230-15","first-page":"341","volume-title":"Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors","author":"Ingalls","year":"1999","journal-title":"Infect Dis Clin North Am"},{"key":"key-10.4103\/0970-9290.186230-16","first-page":"19","volume-title":"Recognition of gram-negative bacteria and endotoxin by the innate immune system","author":"Ulevitch","year":"1999","journal-title":"Curr Opin Immunol"},{"key":"key-10.4103\/0970-9290.186230-17","first-page":"7611","volume-title":"Bacterial lipopolysaccharide activates nuclear factor-kB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes","author":"Zhang","year":"1999","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0970-9290.186230-18","first-page":"1","volume-title":"Development of a classification system for periodontal diseases and conditions","author":"Armitage","year":"1999","journal-title":"Ann Periodontol"},{"key":"key-10.4103\/0970-9290.186230-19","unstructured":"Johnson GD, Dorling J. Immunofluorescence and immune-peroxidase techniques. In: Thompson RA, editor. Techniques in Clinical Immunology. 2nd ed. London: Blackwell Scientific Publications; 1981. p. 106-37."},{"key":"key-10.4103\/0970-9290.186230-20","unstructured":"Bancroft JD, Gamble M. Theory and Practice of Histological Techniques. 5th ed. Edinburgh: Churchill Livingstone; 2002. p. 125-38."},{"key":"key-10.4103\/0970-9290.186230-21","first-page":"8637","volume-title":"Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis","author":"Gao","year":"2007","journal-title":"Mol Cell Biol"},{"key":"key-10.4103\/0970-9290.186230-22","first-page":"194","volume-title":"A clinical and microbiological study to evaluate the effect of dietary supplement of coenzyme Q10 in nonsurgical treatment outcome of chronic periodontitis patients after phase 1 periodontal therapy","author":"Saini","year":"2014","journal-title":"Eur J Gen Dent","ISSN":"https:\/\/id.crossref.org\/issn\/2278-9626","issn-type":"print"},{"key":"key-10.4103\/0970-9290.186230-23","first-page":"263","volume-title":"Toll-like receptors and their dual role in periodontitis: A review","author":"Hans","year":"2011","journal-title":"J Oral Sci"},{"key":"key-10.4103\/0970-9290.186230-24","first-page":"987","volume-title":"Toll-like receptor control of the adaptive immune responses","author":"Iwasaki","year":"2004","journal-title":"Nat Immunol"},{"key":"key-10.4103\/0970-9290.186230-25","first-page":"361","volume-title":"Fundamental mechanisms of host immune responses to infection","author":"Azuma","year":"2006","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0970-9290.186230-26","first-page":"1630","volume-title":"Toll-like receptors in health and disease: Complex questions remain","author":"Sabroe","year":"2003","journal-title":"J Immunol"},{"key":"key-10.4103\/0970-9290.186230-27","first-page":"514","volume-title":"Endogenous ligands of Toll-like receptors","author":"Tsan","year":"2004","journal-title":"J Leukoc Biol"},{"key":"key-10.4103\/0970-9290.186230-28","first-page":"850","volume-title":"DNA from periodontopathogenic bacteria is immunostimulatory for mouse and human immune cells","author":"Nonnenmacher","year":"2003","journal-title":"Infect Immun"},{"key":"key-10.4103\/0970-9290.186230-29","first-page":"3731","volume-title":"Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts","author":"Tabeta","year":"2000","journal-title":"Infect Immun"},{"key":"key-10.4103\/0970-9290.186230-30","first-page":"1161","volume-title":"Toll-like receptor 4-mediated signal pathway induced by Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts","author":"Wang","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"key-10.4103\/0970-9290.186230-31","first-page":"970","volume-title":"DNA microarray analysis of human gingival fibroblasts from healthy and inflammatory gingival tissues","author":"Wang","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"key-10.4103\/0970-9290.186230-32","first-page":"6186","volume-title":"Toll-like receptor 4 gene polymorphism is associated with chronic periodontitis","author":"Ding","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key-10.4103\/0970-9290.186230-33","first-page":"54","volume-title":"Immunohistochemical localization of Toll-like receptors 2 and 4 in gingival tissue from patients with periodontitis","author":"Mori","year":"2003","journal-title":"Oral Microbiol Immunol"},{"key":"key-10.4103\/0970-9290.186230-34","first-page":"1950","volume-title":"The expression profile of lipopolysaccharide-binding protein, membrane-bound CD14, and toll-like receptors 2 and 4 in chronic periodontitis","author":"Ren","year":"2005","journal-title":"J Periodontol"},{"key":"key-10.4103\/0970-9290.186230-35","first-page":"524","volume-title":"Toll-like receptors, NOD1, and NOD2 in oral epithelial cells","author":"Sugawara","year":"2006","journal-title":"J Dent Res"},{"key":"key-10.4103\/0970-9290.186230-36","first-page":"249","volume-title":"Functional TLRs and NODs in human gingival fibroblasts","author":"Uehara","year":"2007","journal-title":"J Dent Res"},{"key":"key-10.4103\/0970-9290.186230-37","first-page":"425","volume-title":"Immunohistochemical localization of Toll-like receptors 1-10 in periodontitis","author":"Beklen","year":"2008","journal-title":"Oral Microbiol Immunol"},{"key":"key-10.4103\/0970-9290.186230-38","first-page":"62","volume-title":"Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis","author":"Rojo-Botello","year":"2012","journal-title":"J Periodontal Res"}],"container-title":["Indian Journal of Dental Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:28:59Z","timestamp":1786714139000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0970-9290.186230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"alternative-id":["186230"],"URL":"https:\/\/doi.org\/10.4103\/0970-9290.186230","relation":{},"ISSN":["0970-9290"],"issn-type":[{"value":"0970-9290","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}