{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:31:43Z","timestamp":1786717903249,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Dent Res"],"published-print":{"date-parts":[[2016]]},"DOI":"10.4103\/0970-9290.186247","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:11:46Z","timestamp":1468887106000},"page":"323","source":"Crossref","is-referenced-by-count":48,"title":["Role of endothelin-1 in periodontal diseases: A structured review"],"prefix":"10.4103","volume":"27","author":[{"given":"Waleed","family":"Khalid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SheejaS","family":"Vargheese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema","family":"Lakshmanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sankari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ND","family":"Jayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0970-9290.186247-1","first-page":"411","volume-title":"Anovel potent vasoconstrictor peptide produced by vascular endothelial cells","author":"Yanagisawa","year":"1988","journal-title":"Nature"},{"key":"key-10.4103\/0970-9290.186247-2","first-page":"2863","volume-title":"The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes","author":"Inoue","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/0970-9290.186247-3","first-page":"134","volume-title":"Microbial complexes in subgingival plaque","author":"Socransky","year":"1998","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0970-9290.186247-4","first-page":"821","volume-title":"Periodontal diseases: Pathogenesis","author":"Offenbacher","year":"1996","journal-title":"Ann Periodontol"},{"key":"key-10.4103\/0970-9290.186247-5","first-page":"618","volume-title":"Endothelin-1 stimulates proinflammatory cytokine expression in human periodontal ligament cells via mitogen-activated protein kinase pathway","author":"Liang","year":"2014","journal-title":"J Periodontol"},{"key":"key-10.4103\/0970-9290.186247-6","first-page":"E19756","volume-title":"Mechanical tension increases CCN2\/CTGF expression and proliferation in gingival fibroblasts via a TGF\u00df-dependent mechanism","author":"Guo","year":"2011","journal-title":"PLoS One"},{"key":"key-10.4103\/0970-9290.186247-7","first-page":"348","volume-title":"Effects of periodontitis on aortic insulin resistance in an obese rat model","author":"Ekuni","year":"2010","journal-title":"Lab Invest"},{"key":"key-10.4103\/0970-9290.186247-8","first-page":"1447","volume-title":"Relationship between gingival angiopoietin-1 concentrations and depth of the adjacent gingival sulcus","author":"Lester","year":"2009","journal-title":"J Periodontol"},{"key":"key-10.4103\/0970-9290.186247-9","first-page":"349","volume-title":"Relationship between endothelin-1 and interleukin-1\u03b2 in inflamed periodontal tissues","author":"Rikimaru","year":"2009","journal-title":"Biomed Res"},{"key":"key-10.4103\/0970-9290.186247-10","first-page":"35","volume-title":"Expression and bioactivities of endothelin-1 in gingiva during cyclosporine A treatment","author":"Chin","year":"2009","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0970-9290.186247-11","first-page":"275","volume-title":"Crevicular fluid endothelin-1 levels in periodontal health and disease","author":"Pradeep","year":"2008","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0970-9290.186247-12","doi-asserted-by":"crossref","unstructured":"Beikler T, Peters U, Prior K, Eisenacher M, Fleming TF. Gene Expression in periodontal tissues following treatment. BMC Med Genomics 2008;1:30. doi:10.1186\/1755-8794-1-30.","DOI":"10.1186\/1755-8794-1-30"},{"key":"key-10.4103\/0970-9290.186247-13","first-page":"290","volume-title":"Endothelin-1 and its receptors ET (A) and ET (B) in drug-induced gingival overgrowth","author":"Tamilselvan","year":"2007","journal-title":"J Periodontol"},{"key":"key-10.4103\/0970-9290.186247-14","first-page":"703","volume-title":"Relationship between calcineurin inhibition and plasma endothelin concentrations in cyclosporine-A-treated kidney transplant patients","author":"B\u00fcchler","year":"2004","journal-title":"Eur J Clin Pharmacol"},{"key":"key-10.4103\/0970-9290.186247-15","first-page":"417","volume-title":"Expression of endothelin-1 in gingival epithelial cells","author":"Yamamoto","year":"2003","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0970-9290.186247-16","first-page":"269","volume-title":"Expression of endothelins and their receptors in cells from human periodontal tissues","author":"Fujioka","year":"2003","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0970-9290.186247-17","first-page":"327S","volume-title":"Effects of periodontopathic bacteria on the expression of endothelin-1 in gingival epithelial cells in adult periodontitis","author":"Ansai","year":"2002","journal-title":"Clin Sci (Lond)"},{"key":"key-10.4103\/0970-9290.186247-18","first-page":"451","volume-title":"Proliferative effects of angiotensin II and endothelin-1 on guinea pig gingival fibroblast cells in culture","author":"Ohuchi","year":"2002","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"key-10.4103\/0970-9290.186247-19","first-page":"844","volume-title":"An investigation of immunocompetence substances in normal gingival and periodontitis tissue","author":"Chen","year":"2000","journal-title":"Chin Med J (Engl)"},{"key":"key-10.4103\/0970-9290.186247-20","first-page":"85","volume-title":"Interactions of lymphotoxin alpha (TNF-beta), angiotensin-converting enzyme (ACE), and endothelin-1 (ET-1) gene polymorphisms in adult periodontitis","author":"Holl\u00e1","year":"2001","journal-title":"J Periodontol"},{"key":"key-10.4103\/0970-9290.186247-21","first-page":"162","volume-title":"Effects of induced periapical abscesses on rat pregnancy outcomes","author":"Bain","year":"2009","journal-title":"Arch Oral Biol"},{"key":"key-10.4103\/0970-9290.186247-22","first-page":"606","volume-title":"Periodontal disease and gene-expression levels of metalloendopeptidases in human buccal mucosal epithelium","author":"Kinoshita","year":"2013","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0970-9290.186247-23","first-page":"250","volume-title":"LPS from Porphyromonas gingivalis increases the sensitivity of contractile response mediated by endothelin-B (ET (B)) receptors in cultured endothelium-intact rat coronary arteries","author":"Ghorbani","year":"2010","journal-title":"Vascul Pharmacol"},{"key":"key-10.4103\/0970-9290.186247-24","first-page":"139","volume-title":"Sequencing, expression and biochemical characterization of the Porphyromonas gingivalis pepO gene encoding a protein homologous to human endothelin-converting enzyme","author":"Awano","year":"1999","journal-title":"FEBS Lett"},{"key":"key-10.4103\/0970-9290.186247-25","first-page":"44","volume-title":"Novel pathogenic role of fibrin as revealed by a case study on ligneous gingivitis","author":"Shimo","year":"2011","journal-title":"Oral Sci Int"},{"key":"key-10.4103\/0970-9290.186247-26","first-page":"501","volume-title":"Thrombin-stimulated proliferation is mediated by endothelin-1 in cultured rat gingival fibroblasts","author":"Ohuchi","year":"2010","journal-title":"Fundam Clin Pharmacol"},{"key":"key-10.4103\/0970-9290.186247-27","first-page":"677","volume-title":"Inhibition of angiotensin II- and endothelin-1-stimulated proliferation by selective MEK inhibitor in cultured rabbit gingival fibroblasts dagger","author":"Ohsawa","year":"2005","journal-title":"Fundam Clin Pharmacol"},{"key":"key-10.4103\/0970-9290.186247-28","first-page":"465","volume-title":"Proliferative response to phenytoin and nifedipine in gingival fibroblasts cultured from humans with gingival fibromatosis","author":"Sano","year":"2004","journal-title":"Fundam Clin Pharmacol"},{"key":"key-10.4103\/0970-9290.186247-29","first-page":"E27097","volume-title":"Gingival fibroblasts display reduced adhesion and spreading on extracellular matrix: A possible basis for scarless tissue repair?","author":"Guo","year":"2011","journal-title":"PLoS One"},{"key":"key-10.4103\/0970-9290.186247-30","first-page":"876","volume-title":"State-of-the-art lecture.Role of endothelin-1 in hypertension","author":"Schiffrin","year":"1999","journal-title":"Hypertension"},{"key":"key-10.4103\/0970-9290.186247-31","first-page":"84","volume-title":"Endothelial dysfunction and atherosclerosis: Endothelin receptor antagonists as novel therapeutics","author":"Barton","year":"2000","journal-title":"Curr Hypertens Rep"},{"key":"key-10.4103\/0970-9290.186247-32","first-page":"1594","volume-title":"Regulation of endothelin-1 synthesis in cultured guinea pig airway epithelial cells by various cytokines","author":"Endo","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"key-10.4103\/0970-9290.186247-33","first-page":"985","volume-title":"Regulation of endothelin-1 by angiopoietin-1: Implications for inflammation","author":"McCarter","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"key":"key-10.4103\/0970-9290.186247-34","first-page":"172","volume-title":"Endothelin in nasal mucosa: Role in nasal function and inflammation","author":"Mullol","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"key-10.4103\/0970-9290.186247-35","first-page":"753","volume-title":"Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells","author":"Imai","year":"1992","journal-title":"Hypertension"},{"key":"key-10.4103\/0970-9290.186247-36","first-page":"131","volume-title":"Endothelin stimulated by angiotensin II augments contractility of spontaneously hypertensive rat resistance arteries","author":"Dohi","year":"1992","journal-title":"Hypertension"},{"key":"key-10.4103\/0970-9290.186247-37","first-page":"321","volume-title":"Morphological assessment of the effects of cyclosporin A on mast cell \u2013 Nerve relationship in atopic dermatitis","author":"Toyoda","year":"1998","journal-title":"Acta Derm Venereol"}],"container-title":["Indian Journal of Dental Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:29:07Z","timestamp":1786714147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0970-9290.186247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"alternative-id":["186247"],"URL":"https:\/\/doi.org\/10.4103\/0970-9290.186247","relation":{},"ISSN":["0970-9290"],"issn-type":[{"value":"0970-9290","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}