{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:42:46Z","timestamp":1759815766761},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":2756,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Med Paediatr Oncol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Context: The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-defined entity, in view of the significant overlap with atypical BL and B-cell lymphoma intermediate between DLBL (diffuse large B cell lymphoma) and BL. They are difficult to be segregated in resource-limited setups which lack molecular testing facilities. This is further affected by interobserver variability and experience of the reporting pathologist. Aims: The aim of our study was to quantitate variability among a group of pathologists with an interest in lymphomas (albeit with variable levels of experience) and quantitate the benefit of joint discussions as a tool to increase accuracy and reduce interobserver variability of pathologists, in the diagnosis of BL in a resource-limited setup. Materials and Methods: A set of 25 non-Hodgkin lymphoma cases in which a diagnosis of BL was entertained were circulated to 14 participating pathologist within the Mumbai lymphoma study group. A proforma recorded the morphologic and immunohistochemical features perceived during the initial independent diagnosis followed by a consensus meeting for discussion on morphology and additional information pertinent to the case. Statistical analysis and Results: The concordance was poor for independent diagnosis among all the pathologists with kappa statistics (\u00b1SE) of 0.168 (\u00b10.018). Expert lymphoma pathologists had the highest (albeit only fair) concordance (kappa = 0.373 \u00b1 0.071) and general pathologists the lowest concordance (kappa = 0.138 \u00b1 0.035). Concordance for morphological diagnosis was highest among expert lymphoma pathologists (kappa = 0.356 \u00b1 0.127). Revision of diagnoses after consensus meeting was highest for B-cell lymphoma intermediate between DLB and BL. To conclude, interobserver variation is a significant problem in BL in the post WHO 2008 classification era. Experience with a larger number of cases and joint discussion exercises such as the one we conducted are needed as they represent a simple and effective way of improving diagnostic accuracy of pathologists working in a resource-limited setup.<\/jats:p>","DOI":"10.4103\/0971-5851.133721","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T13:42:30Z","timestamp":1401716550000},"page":"44-53","source":"Crossref","is-referenced-by-count":4,"title":["Interobserver variation is a significant limitation in the diagnosis of Burkitt lymphoma"],"prefix":"10.1055","volume":"35","author":[{"given":"Swapnil Ulhas","family":"Rane","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tata Memorial Centre, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanuja","family":"Shet","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tata Memorial Centre, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Epari","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tata Memorial Centre, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanica","family":"Bhele","sequence":"additional","affiliation":[{"name":"Department. of Pathology, Prince Aly Khan Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaishali","family":"Gaikwad","sequence":"additional","affiliation":[{"name":"Department of Pathology, L.T. Medical College and Sion Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubhangi","family":"Agale","sequence":"additional","affiliation":[{"name":"Department of Pathology, Grant Medical College and Sir J. J. Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sweety","family":"Shinde","sequence":"additional","affiliation":[{"name":"Department of Pathology, T.N. Medical College and Nair Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daksha","family":"Prabhat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seth G.S. Medical College and K.E.M. Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwendolyn","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seth G.S. Medical College and K.E.M. Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenal","family":"Hastak","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lilavati Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandralekha","family":"Tampi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lilavati Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Narurkar","sequence":"additional","affiliation":[{"name":"Dr. Narurkar\u2032s Laboratory, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyuri","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Bombay Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitra","family":"Madiwale","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hinduja Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketki","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nanavati Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laxmi","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nanavati Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satyakam","family":"Sawaimoon","sequence":"additional","affiliation":[{"name":"Tata Medical Centre, Kolkatta, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purnima","family":"Lad","sequence":"additional","affiliation":[{"name":"Specialty Ranbaxy Ltd, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,7,19]]},"container-title":["Indian Journal of Medical and Paediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/0971-5851.133721.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T16:36:42Z","timestamp":1631032602000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/0971-5851.133721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2021,7,19]]},"published-print":{"date-parts":[[2014,1]]}},"URL":"https:\/\/doi.org\/10.4103\/0971-5851.133721","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0971-5851","0975-2129"],"issn-type":[{"value":"0971-5851","type":"print"},{"value":"0975-2129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}