{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:34:54Z","timestamp":1788798894505,"version":"build-2803163510"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":4250,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Med Paediatr Oncol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background: Langerhans cell histiocytosis (LCH) is a disease that primarily affects bone but can be associated with a clinical spectrum that ranges from a solitary bone lesion with a favorable natural history to a multisystem, life-threatening disease process. Aim: We analyzed our single institutional experience of managing children with LCH. Settings and Design: A total of 40 children of LCH, managed in tertiary cancer center in South India in the period from 2001 to 2005, were evaluated retrospectively. Materials and Methods: Clinicopathological features, laboratory findings, treatment modalities and long-term outcome were analyzed. Results: Children were aged between 2 months and 12 years, with a mean of 3 years. Majority of the children were below 5 years of age. Group B constituted a bulk of children. Disseminated cases were less (five patients). Liver function dysfunction was seen in four (10%) children. Pulmonary interstitial infiltrates were seen in two (5%) cases. Diabetes insipidus manifested in three patients. There was one death. Conclusion:  A better understanding of the etiology and pathogenesis of LCH will result in more directed and efficacious treatment regimens.<\/jats:p>","DOI":"10.4103\/0971-5851.71655","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T09:33:34Z","timestamp":1287048814000},"page":"51-53","source":"Crossref","is-referenced-by-count":8,"title":["Langerhan\u2032s cell histiocytosis: A single institutional experience"],"prefix":"10.1055","volume":"31","author":[{"given":"Tejinder","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore - 560 030, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C T","family":"Satheesh","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore - 560 030, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Appaji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Oncology, Kidwai Memorial Institute of Oncology, Bangalore - 560 030, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B S","family":"Aruna Kumari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Oncology, Kidwai Memorial Institute of Oncology, Bangalore - 560 030, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H S","family":"Mamatha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Oncology, Kidwai Memorial Institute of Oncology, Bangalore - 560 030, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G V","family":"Giri","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bangalore - 560 030, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementina Rama","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore - 560 030, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,11,19]]},"container-title":["Indian Journal of Medical and Paediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/0971-5851.71655.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T23:32:00Z","timestamp":1637364720000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/0971-5851.71655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2021,11,19]]},"published-print":{"date-parts":[[2010,4]]}},"URL":"https:\/\/doi.org\/10.4103\/0971-5851.71655","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0971-5851","0975-2129"],"issn-type":[{"value":"0971-5851","type":"print"},{"value":"0975-2129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}