{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:51:17Z","timestamp":1791492677694,"version":"4.3.4"},"reference-count":23,"publisher":"Scientific Scholar","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Haemoglobinopathies particularly haemoglobin S and E (HbS, HbE) and \u03b2-thalassaemia are important challenges for tribal populations in India. The HbS, HbE and \u03b2-thalassaemia genes are variably distributed across various tribal populations of India. HbE is mainly restricted in tribals of North-East, West Bengal, Odisha and those in Andaman and Nicobar islands. HbS has more extensive distribution in the country (10-40% trait frequency) and the homozygotes and double heterozygotes present with a wide array of morbidities. The morbidity varies greatly in different areas of the country due to differential co-inheritance of \u03b1-thalassaemia gene and interaction of various epistatic and environmental factors. Though substantial data on prevalence of these disorders exist, there is an urgent need to develop integrated hierarchical core facilities to manage the disease. Such centres will generate more data and will also explore areas of management which need more local attention. Newborn screening, genetic counselling, carrier detection, prenatal diagnosis along with management of cases should form the basic infrastructure of haemoglobinopathy management. Research in this areas should continue focusing on various challenges in care delivery, prevention and basic sciences on interaction of haemoglobinopathies with various other infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0971-5916.159488","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T14:02:03Z","timestamp":1734616923000},"page":"505-508","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":32,"title":["Haemoglobinopathies in tribal populations of India"],"prefix":"10.25259","volume":"141","author":[{"given":"Kanjaksha","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan B.","family":"Colah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malay B.","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"R3-2-20241212","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/BF00702780","article-title":"High prevalence of haemoglobin E in two populations in Assam","volume":"12","author":"Das","year":"1971","journal-title":"Humangenetik"},{"key":"R4-2-20241212","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000152506","article-title":"Genetic survey in the population of Assam. I. ABO blood groups, glucose-6-phosphate dehydrogenase and haemoglobin type","volume":"22","author":"Flatz","year":"1972","journal-title":"Hum Hered"},{"key":"R5-2-20241212","first-page":"187","article-title":"Predominance of the haemoglobin E gene in a Mongoloid population in Assam (India)","volume":"30","author":"Das","year":"1975","journal-title":"Humangenetik"},{"key":"R6-2-20241212","first-page":"153","article-title":"Haemoglobin E in six populations of Assam","volume":"15","author":"Das","year":"1980","journal-title":"J Indian Anthropol Soc"},{"key":"R7-2-20241212","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1080\/10245330600840180","article-title":"Anemia and hemoglobinopathies in tribal population of Eastern and North eastern India","volume":"11","author":"De","year":"2006","journal-title":"Hematology"},{"key":"R9-2-20241212","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1081\/HEM-120034244","article-title":"Spectrum of hemoglobinopathies in Orissa, India","volume":"28","author":"Chottray","year":"2004","journal-title":"Hemoglobin"},{"key":"R10-2-20241212","first-page":"1021","article-title":"Spectrum of hemoglobinopathies in the state of Orissa, India: a ten years cohort study","volume":"53","author":"Balgir","year":"2005","journal-title":"J Assoc Physicians India"},{"key":"R11-2-20241212","first-page":"81","article-title":"Hemoglobin Koya Dora: high frequency of a chain termination mutant","volume":"27","author":"De Jong","year":"1975","journal-title":"Am J Hum Genet"},{"key":"R12-2-20241212","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0140-6736(86)92205-1","article-title":"Sickle cell disease in Orissa state, India","volume":"2","author":"Kar","year":"1986","journal-title":"Lancet"},{"key":"R13-2-20241212","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1182\/blood.V71.2.467.467","article-title":"The molecular basis of alpha thalassemia in India. Its interaction with the sickle cell gene","volume":"71","author":"Kulozik","year":"1988","journal-title":"Blood"},{"key":"R14-2-20241212","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/(SICI)1096-8652(199706)55:2<104::AID-AJH9>3.0.CO;2-X","article-title":"Effect of alpha-thalassemia on sickle cell anemia linked to the Arab - Indian haplotype in India","volume":"55","author":"Mukherjee","year":"1997","journal-title":"Am J Hematol"},{"key":"R15-2-20241212","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1136\/jclinpath-2011-200642","article-title":"First case of Hb Fontainebleau with sickle hemoglobin and other non-deletional \u03b1 gene variants identified in neonates during newborn screening for sickle cell disorders","volume":"65","author":"Upadhye","year":"2012","journal-title":"J Clin Pathol"},{"key":"R16-2-20241212","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/ajh.20368","article-title":"Congenital methemoglobinemia caused by Hb-M Ratnagiri (beta-63CAT-->TAT, His-->Tyr) in an Indian family","volume":"79","author":"Kedar","year":"2005","journal-title":"Am J Hematol"},{"key":"R17-2-20241212","first-page":"242","article-title":"Prevalence of sickle cells in Irula, Kurumba, Paniya & Mullukurumba tribes of Nilgiris (Tamil Nadu, India)","volume":"100","author":"Ramasamy","year":"1994","journal-title":"Indian J Med Res"},{"key":"R18-2-20241212","first-page":"267","article-title":"Sickle cell disease in Wayanad, Kerala: gene frequencies and disease characteristics","volume":"14","author":"Feroze","year":"2001","journal-title":"Natl Med J India"},{"key":"R19-2-20241212","first-page":"479","article-title":"Haplotypes in tribal Indians bearing the sickle gene: evidence for the unicentric origin of the beta S mutation and the unicentric origin of the tribal populations of India","volume":"61","author":"Labie","year":"1989","journal-title":"Hum Biol"},{"key":"R20-2-20241212","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MOH.0000000000000029","article-title":"Sickle cell disease in India","volume":"21","author":"Colah","year":"2014","journal-title":"Curr Opin Hematol"},{"key":"R21-2-20241212","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/1096-8652(199610)53:2<149::AID-AJH2830530203>3.0.CO;2-H","article-title":"Alpha genotyping in a heterogeneous Indian population","volume":"53","author":"Nadkarni","year":"1996","journal-title":"Am J Hematol"},{"key":"R22-2-20241212","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/03630269.2013.774284","article-title":"Variable presentation of Hb H disease due to homozygosity for the rare polyadenylation signal AT (Indian) (AATAAA \u2192 AATA--) mutation in four Indian families","volume":"37","author":"Nair","year":"2013","journal-title":"Hemoglobin"},{"key":"R23-2-20241212","first-page":"561","article-title":"Genetic counselling in tribals in India","volume":"134","author":"Mohanty","year":"2011","journal-title":"Indian J Med Res"},{"key":"R24-2-20241212","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bcmd.2008.08.003","article-title":"Hydroxyurea in sickle cell disease - a study of clinico - pharmacological efficacy in the Indian haplotype","volume":"42","author":"Italia","year":"2009","journal-title":"Blood Cells Mol Dis"},{"key":"R25-2-20241212","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s13312-013-0264-0","article-title":"Efficacy of fixed low dose hydroxyurea in Indian children with sickle cell anemia: a single centre experience","volume":"50","author":"Jain","year":"2013","journal-title":"Indian Pediatr"},{"key":"R26-2-20241212","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cca.2009.06.019","article-title":"Response to hydroxyurea in beta-thalassemia major and intermedia: experience in western India","volume":"407","author":"Italia","year":"2009","journal-title":"Clin Chim Acta"}],"container-title":["Indian Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/02223309-201541050-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T18:55:45Z","timestamp":1751482545000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijmr.org.in\/haemoglobinopathies-in-tribal-populations-of-india\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0971-5916.159488","relation":{},"ISSN":["0971-5916"],"issn-type":[{"value":"0971-5916","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}