{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:29:05Z","timestamp":1793456945239,"version":"4.5.0"},"reference-count":46,"publisher":"Scientific Scholar","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>The sickle gene is widespread among many tribal population groups in India with prevalence of heterozygotes varying from 1-40 per cent. Co-inheritance of the sickle gene with \u03b2-thalassaemia, HbD Punjab and glucose-6-phosphate dehydrogenase (G6PD) deficiency has also been reported. Most of the screening programmes in India now use high performance liquid chromatography (HPLC) analysis although the solubility test is also sensitive and cheap. Sickle cell disease (SCD) among tribal populations is generally milder than among non-tribal groups with fewer episodes of painful crises, infections, acute chest syndrome and need for hospitalization. This has partly been attributed to the very high prevalence of \u03b1-thalassaemia among these tribes as well as higher foetal haemoglobin levels. However, the clinical presentation is variable with many cases having a severe presentation. There is not much information available on maternal and perinatal outcome in tribal women with sickle cell disease. Newborn screening programmes for SCD have recently been initiated in Maharashtra, Gujarat, Odisha and Chattisgarh and monitoring these birth cohorts will help to understand the natural history of SCD in India. Prenatal diagnosis is acceptable by tribal families in India. The Indian Council of Medical Research and the National Rural Health Mission in different States are undertaking outreach programmes for better management and control of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0971-5916.159492","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T14:02:47Z","timestamp":1734616967000},"page":"509-515","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":101,"title":["Sickle cell disease in tribal populations in India"],"prefix":"10.25259","volume":"141","author":[{"given":"Roshan B.","family":"Colah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malay B.","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanjaksha","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"R2-3-20241212","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0140-6736(04)17192-4","article-title":"Sickle cell disease","volume":"364","author":"Stuart","year":"2004","journal-title":"Lancet"},{"key":"R3-3-20241212","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(10)61029-X","article-title":"Sickle cell disease","volume":"376","author":"Rees","year":"2010","journal-title":"Lancet"},{"key":"R4-3-20241212","first-page":"532","article-title":"Pathophysiological insights in sickle cell disease","volume":"134","author":"Odi\u00e8vre","year":"2011","journal-title":"Indian J Med Res"},{"key":"R7-3-20241212","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nature08365","article-title":"Restructuring Indian population history","volume":"461","author":"Reich","year":"2009","journal-title":"Nature"},{"key":"R8-3-20241212","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/bmj.1.4755.404","article-title":"Sickle cell trait in southern India","volume":"1","author":"Lehman","year":"1952","journal-title":"Brit Med J"},{"key":"R9-3-20241212","first-page":"387","article-title":"The occurrence of sickle cell anemia among a group of tea garden labourers in Upper Assam","volume":"87","author":"Dunlop","year":"1952","journal-title":"Indian Med Gaz"},{"key":"R11-3-20241212","first-page":"218","article-title":"Genetics and epidemiology of sickle cell anemia in India","volume":"42","author":"Rao","year":"1988","journal-title":"Indian J Med Sci"},{"key":"R12-3-20241212","first-page":"104","article-title":"Sickle cell trait and disease among tribal communities in Orissa, Madhya Pradesh and Kerala","volume":"55","author":"Kaur","year":"1997","journal-title":"Indian J Med Res"},{"key":"R13-3-20241212","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/09723757.2002.11885800","article-title":"Epidemiology of sickle cell disorder in the state of Maharashtra","volume":"3","author":"Kate","year":"2002","journal-title":"Indian J Hum Genet"},{"key":"R14-3-20241212","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12687-011-0050-4","article-title":"Screening for the sickle cell gene in Chhattisgarh state, India: an approach to a major public health problem","volume":"2","author":"Patra","year":"2011","journal-title":"J Community Genet"},{"key":"R15-3-20241212","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4236\/ojbd.2012.24014","article-title":"Incidence of sickle cell anemia and thalassemia in Central India","volume":"2","author":"Urade","year":"2012","journal-title":"Open J Blood Dis"},{"key":"R16-3-20241212","first-page":"60","article-title":"Burden of sickle cell disease among tribes of India: A burning problem","volume":"3","author":"Kaur","year":"2013","journal-title":"Int Res J Pharm App Sci"},{"key":"R17-3-20241212","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MOH.0000000000000029","article-title":"Sickle cell disease in India","volume":"21","author":"Colah","year":"2014","journal-title":"Curr Opin Hematol"},{"key":"R18-3-20241212","first-page":"1","article-title":"Sickle cell disease load in Madhya Pradesh. 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