{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:17:55Z","timestamp":1777670275486,"version":"3.51.4"},"reference-count":115,"publisher":"Scientific Scholar","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Med Res"],"published-print":{"date-parts":[[2015]]},"DOI":"10.4103\/0971-5916.169193","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T10:46:35Z","timestamp":1461321995000},"page":"369","source":"Crossref","is-referenced-by-count":13,"title":["Alzheimer\u2032s disease: Unique markers for diagnosis &amp; new treatment modalities"],"prefix":"10.25259","volume":"142","author":[{"given":"NeelumT","family":"Aggarwal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RajC","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DavidA","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"key":"key-10.4103\/0971-5916.169193-1","first-page":"380","volume-title":"The epidemiology of the dementias: an update","author":"Qui","year":"2007","journal-title":"Curr Opin Psychiatry"},{"key":"key-10.4103\/0971-5916.169193-2","unstructured":"World Health Organization and Alzheimer\u2032s Disease International. Dementia: a public health priority. Available from: http:\/\/www.who.int\/mental_health\/publications\/dementia_ report_2012\/en, accessed on August 20, 2015."},{"key":"key-10.4103\/0971-5916.169193-3","first-page":"464","volume-title":"Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey","author":"Llibre","year":"2008","journal-title":"Lancet"},{"key":"key-10.4103\/0971-5916.169193-4","unstructured":"World Alzheimer\u2032s Report 2010. Available from: ,\">http:\/\/www.alz.org\/documents\/national\/Worldalzheimerreport2010.pdf, accessed on August 20, 2015."},{"key":"key-10.4103\/0971-5916.169193-5","first-page":"78","volume-title":"Demographic aging: implications for mental health","author":"Sathyanarayana","year":"2007","journal-title":"Indian J Psychiatry"},{"key":"key-10.4103\/0971-5916.169193-6","first-page":"745","volume-title":"An epidemiological study of dementia in a rural community in Kerala, India","author":"Shaji","year":"1996","journal-title":"Br J Psychiatry"},{"key":"key-10.4103\/0971-5916.169193-7","first-page":"702","volume-title":"Prevalence of dementia in a rural setting: a report from India","author":"Rajkumar","year":"1997","journal-title":"Int J Geriatr Psychiatry"},{"key":"key-10.4103\/0971-5916.169193-8","first-page":"57","volume-title":"Prevalence of dementia in the community: a rural-urban comparison from Madras, India","author":"Rajkumar","year":"1996","journal-title":"Australas J Aging"},{"key":"key-10.4103\/0971-5916.169193-9","first-page":"136","volume-title":"Prevalence of dementia in an urban population in Kerala, India","author":"Shaji","year":"2005","journal-title":"Br J Psychiatry"},{"key":"key-10.4103\/0971-5916.169193-10","first-page":"1000","volume-title":"Prevalence of Alzheimer\u2032s disease and other dementias in rural India: the Indo-US study","author":"Chandra","year":"1998","journal-title":"Neurology"},{"key":"key-10.4103\/0971-5916.169193-11","first-page":"219","volume-title":"The 10\/66 Dementia Research Group\u2032s fully operationalised DSM-IV dementia computerized diagnostic algorithm, compared with the 10\/66 dementia algorithm and a clinician diagnosis: a population validation study","author":"Prince","year":"2008","journal-title":"BMC Public Health"},{"key":"key-10.4103\/0971-5916.169193-12","first-page":"2112","volume-title":"Global prevalence of dementia: a Delphi consensus study","author":"Ferri","year":"2005","journal-title":"Lancet"},{"key":"key-10.4103\/0971-5916.169193-13","first-page":"263","volume-title":"The diagnosis of dementia due to Alzheimer\u2032s disease: recommendations from the National Institute on Aging-Alzheimer\u2032s Association workgroups on diagnostic guidelines for Alzheimer\u2032s disease","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"key-10.4103\/0971-5916.169193-14","first-page":"270","volume-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2032s disease: recommendations from the National Institute on Aging-Alzheimer\u2032s Association workgroups on diagnostic guidelines for Alzheimer\u2032s disease","author":"Albert","year":"2011","journal-title":"Alzheimers Dement"},{"key":"key-10.4103\/0971-5916.169193-15","first-page":"280","volume-title":"Toward defining the preclinical stages of Alzheimer\u2032s disease: Recommendations from the National Institute on Aging-Alzheimer\u2032s Association workgroups on diagnostic guidelines for Alzheimer\u2032s disease","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement"},{"key":"key-10.4103\/0971-5916.169193-16","unstructured":"National Institute on Aging\u2032s document titled \"Alzheimer\u2032s Disease: Unraveling the Mystery,\" Available from: https:\/\/d2cauhfh6h4x0p.cloudfront.net\/s3fs-public\/alzheimers_disease_unraveling_the_mystery_0.pdf, accessed on September 11, 2015."},{"key":"key-10.4103\/0971-5916.169193-17","first-page":"257","volume-title":"Introduction to the recommendations from the National Institute on Aging-Alzheimer\u2032s Association workgroups on diagnostic guidelines for Alzheimer\u2032s disease","author":"Jack","year":"2011","journal-title":"Alzheimers Dement"},{"key":"key-10.4103\/0971-5916.169193-18","first-page":"S3","volume-title":"Alzheimer disease: update on basic mechanisms","author":"Bi","year":"2010","journal-title":"J Am Osteopath Assoc"},{"key":"key-10.4103\/0971-5916.169193-19","first-page":"599","volume-title":"Relation of neuropathology to cognition in persons without cognitive impairment","author":"Bennett","year":"2012","journal-title":"Ann Neurol"},{"key":"key-10.4103\/0971-5916.169193-20","first-page":"178","volume-title":"Amyloid deposition is associated with impaired default network function in older persons without dementia","author":"Sperling","year":"2009","journal-title":"Neuron"},{"key":"key-10.4103\/0971-5916.169193-21","first-page":"344","volume-title":"Alzheimer disease: new concepts on its neurobiology and the clinical role imaging will play","author":"Jack","year":"2012","journal-title":"Radiology"},{"key":"key-10.4103\/0971-5916.169193-22","first-page":"1","volume-title":"Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer\u2032s disease","author":"Ringman","year":"2012","journal-title":"Dement Geriatr Cogn Disord"},{"key":"key-10.4103\/0971-5916.169193-23","first-page":"1","volume-title":"Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging and the Alzheimer\u2032s Association","author":"Johnson","year":"2013","journal-title":"Alzheimers Dement"},{"key":"key-10.4103\/0971-5916.169193-24","first-page":"457","volume-title":"Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807","author":"Chien","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"key-10.4103\/0971-5916.169193-25","first-page":"e25074","volume-title":"An MRI-derived definition of MCI-to-AD conversion for long-term, automatic prognosis of MCI patients","author":"Aksu","year":"2011","journal-title":"PLoS One"},{"key":"key-10.4103\/0971-5916.169193-26","first-page":"1777","volume-title":"3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer\u2032s disease","author":"Whitwell","year":"2007","journal-title":"Brain"},{"key":"key-10.4103\/0971-5916.169193-27","first-page":"871","volume-title":"What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia?","author":"Jagust","year":"2007","journal-title":"Neurology"},{"key":"key-10.4103\/0971-5916.169193-28","first-page":"11193","volume-title":"Effects of brain amyloid deposition and reduced glucose metabolism on the default mode of brain function in normal aging","author":"Kikuchi","year":"2011","journal-title":"J Neurosci"},{"key":"key-10.4103\/0971-5916.169193-29","first-page":"1247","volume-title":"Effects of age on the glucose metabolic changes in mild cognitive impairment","author":"Kantarci","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"key":"key-10.4103\/0971-5916.169193-30","first-page":"1474","volume-title":"Medial temporal lobe atrophy relates to executive dysfunction in Alzheimer\u2032s disease","author":"Oosterman","year":"2012","journal-title":"Int Psychogeriatr"},{"key":"key-10.4103\/0971-5916.169193-31","first-page":"51","volume-title":"Beyond the signaling effect role of amyloid-\u00df42 on the processing of APP, and its clinical implications","author":"Lahiri","year":"2010","journal-title":"Exp Neurol"},{"key":"key-10.4103\/0971-5916.169193-32","first-page":"18","volume-title":"Signaling effect of amyloid-beta(42) on the processing of AbetaPP","author":"Tabaton","year":"2010","journal-title":"Exp Neurol"},{"key":"key-10.4103\/0971-5916.169193-33","first-page":"4354","volume-title":"Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems","author":"Baruch-Suchodolsky","year":"2009","journal-title":"Biochemistry"},{"key":"key-10.4103\/0971-5916.169193-34","first-page":"328","volume-title":"Amyloid beta-protein stimulates trafficking of cholesterol and caveolin-1 from the plasma membrane to the Golgi complex in mouse primary astrocytes","author":"Igbavboa","year":"2009","journal-title":"Neuroscience"},{"key":"key-10.4103\/0971-5916.169193-35","first-page":"e9505","volume-title":"The Alzheimer\u2032s disease-associated amyloid beta-protein is an antimicrobial peptide","author":"Soscia","year":"2010","journal-title":"PLoS One"},{"key":"key-10.4103\/0971-5916.169193-36","first-page":"41","volume-title":"Cerebral amyloid angiopathy","author":"Yamada","year":"2012","journal-title":"Prog Mol Biol Transl Sci"},{"key":"key-10.4103\/0971-5916.169193-37","first-page":"239","volume-title":"Neuropathological staging of Alzheimer-related changes","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"key-10.4103\/0971-5916.169193-38","first-page":"1860","volume-title":"Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer\u2032s disease","author":"Buckner","year":"2009","journal-title":"J Neurosci"},{"key":"key-10.4103\/0971-5916.169193-39","first-page":"1635","volume-title":"Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden","author":"Drzezga","year":"2011","journal-title":"Brain"},{"key":"key-10.4103\/0971-5916.169193-40","first-page":"1355","volume-title":"Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer\u2032s disease: implications for sequence of pathological events in Alzheimer\u2032s disease","author":"Jack","year":"2009","journal-title":"Brain"},{"key":"key-10.4103\/0971-5916.169193-41","first-page":"907409","volume-title":"Multimodal MRI neuroimaging biomarkers for cognitive normal adults, amnestic mild cognitive impairment, and Alzheimer\u2032s disease","author":"Lin","year":"2012","journal-title":"Neurol Res Int"},{"key":"key-10.4103\/0971-5916.169193-42","first-page":"1196","volume-title":"Neural correlates of Alzheimer\u2032s disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients","author":"Schroeter","year":"2009","journal-title":"Neuroimage"},{"key":"key-10.4103\/0971-5916.169193-43","first-page":"317","volume-title":"Australian Imaging Biomarkers and Lifestyle Research Group.Relationship between atrophy and beta-amyloid deposition in Alzheimer disease","author":"Ch\u00e9telat","year":"2010","journal-title":"Ann Neurol"},{"key":"key-10.4103\/0971-5916.169193-44","first-page":"387","volume-title":"0\u00e2-Amyloid burden in healthy aging: regional distribution and cognitive consequences","author":"Rodrigue","year":"2012","journal-title":"Neurology"},{"key":"key-10.4103\/0971-5916.169193-45","first-page":"1456","volume-title":"PET imaging of amyloid deposition in patients with mild cognitive impairment","author":"Forsberg","year":"2008","journal-title":"Neurobiol Aging"},{"key":"key-10.4103\/0971-5916.169193-46","first-page":"754","volume-title":"Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study","author":"Okello","year":"2009","journal-title":"Neurology"},{"key":"key-10.4103\/0971-5916.169193-47","first-page":"e10659","volume-title":"Alzheimer\u2032s disease amyloid-beta links lens and brain pathology in Down syndrome","author":"Moncaster","year":"2010","journal-title":"PLoS One"},{"key":"key-10.4103\/0971-5916.169193-48","first-page":"795","volume-title":"Dominantly inherited Alzheimer network","author":"Bateman","year":"2012","journal-title":"N Engl J Med"},{"key":"key-10.4103\/0971-5916.169193-49","first-page":"2262","volume-title":"Toward a multifactorial model of Alzheimer disease","author":"Storandt","year":"2012","journal-title":"Neurobiol Aging"},{"key":"key-10.4103\/0971-5916.169193-50","first-page":"361","volume-title":"On the discovery of the genetic association of apolipoprotein E genotypes and common late-onset Alzheimer disease","author":"Roses","year":"2006","journal-title":"J Alzheimers Dis"},{"key":"key-10.4103\/0971-5916.169193-51","first-page":"39","volume-title":"The use of single nucleotide polymorphisms in the isolation of common disease genes","author":"Riley","year":"2000","journal-title":"Pharmacogenomics"},{"key":"key-10.4103\/0971-5916.169193-52","first-page":"S20","volume-title":"Genetics: finding risk factors","author":"Eisenstein","year":"2011","journal-title":"Nature"},{"key":"key-10.4103\/0971-5916.169193-53","first-page":"e21896","volume-title":"Identification of conversion from mild cognitive impairment to Alzheimer\u2032s disease using multivariate predictors","author":"Cui","year":"2011","journal-title":"PLoS One"},{"key":"key-10.4103\/0971-5916.169193-54","first-page":"2032","volume-title":"Apolipoprotein E promotes \u00e2-amyloid trafficking and degradation by modulating microglial cholesterol levels","author":"Lee","year":"2012","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0971-5916.169193-55","first-page":"1452","volume-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2032s disease","author":"Lambert","year":"2013","journal-title":"Nat Genet"},{"key":"key-10.4103\/0971-5916.169193-56","first-page":"e94661","volume-title":"Gene-wide analysis detects two new susceptibility genes for Alzheimer\u2032s disease","author":"Escott-Price","year":"2014","journal-title":"PLoS One"},{"key":"key-10.4103\/0971-5916.169193-57","first-page":"1150","volume-title":"Genetic susceptibility for Alzheimer\u2032s disease neuritic plaque pathology","author":"Shulman","year":"2013","journal-title":"JAMA Neurol"},{"key":"key-10.4103\/0971-5916.169193-58","first-page":"848","volume-title":"CD33 Alzheimer\u2032s disease locus: altered monocyte function and amyloid biology","author":"Bradshaw","year":"2013","journal-title":"Nat Neurosci"},{"key":"key-10.4103\/0971-5916.169193-59","first-page":"1156","volume-title":"Alzheimer\u2032s disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2, and other loci","author":"De","year":"2014","journal-title":"Nat Neurosci"},{"key":"key-10.4103\/0971-5916.169193-60","first-page":"345","volume-title":"Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer\u2032s disease: clinical molecular and genetic studies on Alzheimer\u2032s disease","author":"Shoji","year":"2012","journal-title":"J Pharmacol Sci"},{"key":"key-10.4103\/0971-5916.169193-61","first-page":"e21643","volume-title":"Metabolomics in early Alzheimer\u2032s disease: identification of altered plasma sphingolipidome using shotgun lipidomics","author":"Han","year":"2011","journal-title":"PLoS One"},{"key":"key-10.4103\/0971-5916.169193-62","first-page":"259","volume-title":"Plasma sphingomyelins are associated with cognitive progression in Alzheimer\u2032s disease","author":"Mielke","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"key-10.4103\/0971-5916.169193-63","first-page":"42","volume-title":"Serum lipids are related to Alzheimer\u2032s pathology in nursing home residents","author":"Lesser","year":"2009","journal-title":"Dement Geriatr Cogn Disord"},{"key":"key-10.4103\/0971-5916.169193-64","first-page":"303","volume-title":"Cholesterol and LDL relate to neuritic plaques and to APOE4 presence but not to neurofibrillary tangles","author":"Lesser","year":"2011","journal-title":"Curr Alzheimer Res"},{"key":"key-10.4103\/0971-5916.169193-65","first-page":"39","volume-title":"Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients","author":"Mandas","year":"2012","journal-title":"Lipids Health Dis"},{"key":"key-10.4103\/0971-5916.169193-66","first-page":"200","volume-title":"The neuropathology of probable Alzheimer disease and mild cognitive impairment","author":"Schneider","year":"2009","journal-title":"Ann Neurol"},{"key":"key-10.4103\/0971-5916.169193-67","first-page":"e26286","volume-title":"Neuropathologic correlates of hippocampal atrophy in the elderly: a clinical, pathologic, postmortem MRI study","author":"Dawe","year":"2011","journal-title":"PLoS One"},{"key":"key-10.4103\/0971-5916.169193-68","first-page":"275","volume-title":"Use of florbetapir-PET for imaging beta-amyloid pathology","author":"Clark","year":"2011","journal-title":"JAMA"},{"key":"key-10.4103\/0971-5916.169193-69","first-page":"4252","volume-title":"(E)-5-styryl-1H-indole and (E)-6-styrylquinoline derivatives serve as probes for \u00e2-amyloid plaques","author":"Yang","year":"2012","journal-title":"Molecules"},{"key":"key-10.4103\/0971-5916.169193-70","first-page":"651","volume-title":"Efficient near-infrared in vivo imaging of amyloid-\u00e2 deposits in Alzheimer\u2032s disease mouse models","author":"Schmidt","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"key-10.4103\/0971-5916.169193-71","first-page":"666","volume-title":"Tau as a therapeutic target for Alzheimer\u2032s disease","author":"Boutajangout","year":"2011","journal-title":"Curr Alzheimer Res"},{"key":"key-10.4103\/0971-5916.169193-72","first-page":"387","volume-title":"Alzheimer\u2032s disease: strategies for disease modification","author":"Citron","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"key-10.4103\/0971-5916.169193-73","first-page":"545","volume-title":"Alzheimer\u2032s disease: molecular understanding predicts amyloid-based therapeutics","author":"Selkoe","year":"2003","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"key-10.4103\/0971-5916.169193-74","first-page":"40","volume-title":"Towards disease-modifying treatment of Alzheimer\u2032s disease: drugs targeting beta-amyloid","author":"Frisardi","year":"2010","journal-title":"Curr Alzheimer Res"},{"key":"key-10.4103\/0971-5916.169193-75","first-page":"S10","volume-title":"Current insights into the pathophysiology of Alzheimer\u2032s disease: selecting targets for early therapeutic intervention","author":"Hampel","year":"2012","journal-title":"Int Psychogeriatr"},{"key":"key-10.4103\/0971-5916.169193-76","first-page":"203","volume-title":"Disease-modifying treatments for Alzheimer\u2032s disease","author":"Galimberti","year":"2011","journal-title":"Ther Adv Neurol Disord"},{"key":"key-10.4103\/0971-5916.169193-77","first-page":"1129","volume-title":"The amyloid hypothesis for Alzheimer\u2032s disease: a critical reappraisal","author":"Hardy","year":"2009","journal-title":"J Neurochem"},{"key":"key-10.4103\/0971-5916.169193-78","first-page":"1005","volume-title":"Atorvastatin-induced activation of Alzheimer\u2032s alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding","author":"Parvathy","year":"2004","journal-title":"J Neurochem"},{"key":"key-10.4103\/0971-5916.169193-79","first-page":"305","volume-title":"Dual effects of statins on A\u00e2 metabolism: upregulation of the degradation of APP-CTF and A\u00e2 clearance","author":"Sato","year":"2012","journal-title":"Neurodegener Dis"},{"key":"key-10.4103\/0971-5916.169193-80","first-page":"202","volume-title":"Regulation of beta APP and PrPc cleavage by alpha-secretase: mechanistic and therapeutic perspectives","author":"Vincent","year":"2008","journal-title":"Curr Alzheimer Res"},{"key":"key-10.4103\/0971-5916.169193-81","first-page":"1243","volume-title":"Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before","author":"Mancuso","year":"2011","journal-title":"Expert Opin Investig Drugs"},{"key":"key-10.4103\/0971-5916.169193-82","first-page":"423","volume-title":"Brain insulin and insulin receptors in aging and sporadic Alzheimer\u2032s disease","author":"Frolich","year":"1998","journal-title":"J Neural Transm"},{"key":"key-10.4103\/0971-5916.169193-83","first-page":"341","volume-title":"The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update","author":"Hoyer","year":"2002","journal-title":"J Neural Transm"},{"key":"key-10.4103\/0971-5916.169193-84","first-page":"115","volume-title":"Glucose metabolism and insulin receptor signal transduction in Alzheimer disease","author":"Hoyer","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"key-10.4103\/0971-5916.169193-85","first-page":"247","volume-title":"Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer\u2032s disease: link to brain reductions in acetylcholine","author":"Rivera","year":"2005","journal-title":"J Alzheimers Dis"},{"key":"key-10.4103\/0971-5916.169193-86","first-page":"63","volume-title":"Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer\u2032s disease--is this type 3 diabetes?","author":"Steen","year":"2005","journal-title":"J Alzheimers Dis"},{"key":"key-10.4103\/0971-5916.169193-87","first-page":"1316","volume-title":"Demonstrated brain insulin resistance in Alzheimer\u2032s disease patients is associated with IGF-1, resistant, IRS-1 dysregulation and cognitive decline","author":"Talbot","year":"2012","journal-title":"J Clin Invest"},{"key":"key-10.4103\/0971-5916.169193-88","first-page":"29","volume-title":"Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial","author":"Craft","year":"2012","journal-title":"Arch Neurol"},{"key":"key-10.4103\/0971-5916.169193-89","first-page":"440","volume-title":"Intranasal insulin improves cognition and modulates beta-amyloid in early AD","author":"Reger","year":"2008","journal-title":"Neurology"},{"key":"key-10.4103\/0971-5916.169193-90","unstructured":"US National Institutes of Health. Study of nasal insulin to fight forgetfulness - short-acting insulin aspart (SNIFF-Quick) Unique ID: NCT02462161 Available from: https:\/\/clinicaltrials.gov, accessed on August 20, 2015."},{"key":"key-10.4103\/0971-5916.169193-91","first-page":"102","volume-title":"Tramiprosate in mild-to-moderate Alzheimer\u2032s disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)","author":"Aisen","year":"2011","journal-title":"Arch Med Sci"},{"key":"key-10.4103\/0971-5916.169193-92","first-page":"1253","volume-title":"A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease","author":"Salloway","year":"2011","journal-title":"Neurology"},{"key":"key-10.4103\/0971-5916.169193-93","first-page":"856","volume-title":"Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo","author":"Bateman","year":"2006","journal-title":"Nat Med"},{"key":"key-10.4103\/0971-5916.169193-94","first-page":"1503","volume-title":"ApoE-directed therapeutics rapidly clear \u00e2-amyloid and reverse deficits in AD mouse models","author":"Cramer","year":"2012","journal-title":"Science"},{"key":"key-10.4103\/0971-5916.169193-95","first-page":"1014","volume-title":"Anti-apoptotic roles of plasminogen activator inhibitor-1 as a neurotrophic factor in the central nervous system","author":"Soeda","year":"2008","journal-title":"Thromb Haemost"},{"key":"key-10.4103\/0971-5916.169193-96","first-page":"951","volume-title":"Peripheral administration of antisense oligonucleotides targeting the amyloid-\u00e2 protein precursor reverses A\u00e2PP and LRP-1 overexpression in the aged SAMP8 mouse brain","author":"Erickson","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"key-10.4103\/0971-5916.169193-97","first-page":"734956","volume-title":"The complexity of sporadic Alzheimer\u2032s disease pathogenesis: the role of RAGE as therapeutic target to promote neuroprotection by inhibiting neurovascular dysfunction","author":"Perrone","year":"2012","journal-title":"Int J Alzheimers Dis"},{"key":"key-10.4103\/0971-5916.169193-98","first-page":"17","volume-title":"Vaccination as a therapeutic approach to Alzheimer\u2032s disease","author":"Wisniewski","year":"2010","journal-title":"Mt Sinai J Med"},{"key":"key-10.4103\/0971-5916.169193-99","first-page":"216","volume-title":"Long-term effects of Abeta 42 immunisation in Alzheimer\u2032s disease: follow-up of a randomised, placebo-controlled phase I trial","author":"Holmes","year":"2008","journal-title":"Lancet"},{"key":"key-10.4103\/0971-5916.169193-100","first-page":"173","volume-title":"Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse","author":"Schenk","year":"1999","journal-title":"Nature"},{"key":"key-10.4103\/0971-5916.169193-101","first-page":"213","volume-title":"Immunotherapy for Alzheimer\u2032s disease: from anti-\u00e2-amyloid to tau-based immunization strategies","author":"Panza","year":"2012","journal-title":"Immunotherapy"},{"key":"key-10.4103\/0971-5916.169193-102","first-page":"1002","volume-title":"Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease","author":"Blennow","year":"2012","journal-title":"Arch Neurol"},{"key":"key-10.4103\/0971-5916.169193-103","first-page":"787","volume-title":"Solanezumab for Alzheimer\u2032s disease","author":"Samadi","year":"2011","journal-title":"Expert Opin Biol Ther"},{"key":"key-10.4103\/0971-5916.169193-104","first-page":"5847","volume-title":"Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer\u2032s disease","author":"Dodel","year":"2011","journal-title":"J Neurosci"},{"key":"key-10.4103\/0971-5916.169193-105","unstructured":"Strobel G. Collaborative umbrella CAPS three prevention trial initiatives. Alzheimer\u2032s Association International Conference 2012. Available from: \">http:\/\/www.alzforum.org\/new\/detail.aspid=3232., accessed on August 9, 2015."},{"key":"key-10.4103\/0971-5916.169193-106","unstructured":"Strobel G, Zaraib BD. Solanuzemab selected for Alzheimer\u2032s A4 prevention trial. Human Amyloid Imaging 2013. Available from: ,\">http:\/\/www.alzforum.org\/new\/detail.asp?id=3379, accessed on August 1, 2015."},{"key":"key-10.4103\/0971-5916.169193-107","first-page":"228fs13","volume-title":"The A4 study: stopping AD before symptoms begin?","author":"Sperling","year":"2014","journal-title":"Sci Transl Med"},{"key":"key-10.4103\/0971-5916.169193-108","unstructured":"National Institute on Aging. Dominant Inherited Alzheimer Network trial: an opportunity to prevent dementia (DIAN TU) c2013 Available from: https:\/\/www.nia.nih.gov\/alzheimers\/clinical-trials\/dominantly-inherited-alzheimer-network-trial-opportunity-prevent-dementia, accessed on August 20, 2015."},{"key":"key-10.4103\/0971-5916.169193-109","first-page":"321","volume-title":"Alzheimer\u2032s Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments","author":"Reiman","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"key-10.4103\/0971-5916.169193-110","unstructured":"APOE treatment study. Available from: http:\/\/banneralz.org\/research-plus-discovery\/alzheimers-prevention-initiative.aspx, accessed on August 20, 2015."},{"key":"key-10.4103\/0971-5916.169193-111","unstructured":"US National Institutes of Health. Biomarker qualification for risk of mild cognitive impairment (MCI) due to Alzheimer\u2032s disease (AD) and safety and efficacy evaluation of pioglitazone in delaying its onset (TOMMORROW) Available from: https:\/\/ clinicaltrials.gov., accessed on August 20, 2015."},{"key":"key-10.4103\/0971-5916.169193-112","unstructured":"US National Institutes of Health. Longitudinal evaluation of amyloid risk and neurodegeneration - the LEARN study. Available from: https:\/\/clinicaltrials.gov, accessed on August 20, 2015."},{"key":"key-10.4103\/0971-5916.169193-113","unstructured":"US National Institutes of Health. A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer disease, including a placebo-treated non-carrier cohort. Available from: https:\/\/ clinicaltrials.gov, accessed on August 20, 2015."},{"key":"key-10.4103\/0971-5916.169193-114","unstructured":"Government of India. Schedule Y: Requirements and guidelines for permission to import and\/or manufacture of new drugs for sale or to undertake clinical trials. Drugs and Cosmetics Rules 1945; India, 2003."},{"key":"key-10.4103\/0971-5916.169193-115","first-page":"101","volume-title":"Patient protection in clinical trials in India: some concerns","author":"Srinivasan","year":"2010","journal-title":"Perspect Cln Res"}],"container-title":["Indian Journal of Medical Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T22:56:23Z","timestamp":1751496983000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijmr.org.in\/alzheimers-disease-unique-markers-for-diagnosis-new-treatment-modalities\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":115,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"alternative-id":["169193"],"URL":"https:\/\/doi.org\/10.4103\/0971-5916.169193","relation":{},"ISSN":["0971-5916"],"issn-type":[{"value":"0971-5916","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}