{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:22:27Z","timestamp":1751516547862,"version":"3.41.0"},"reference-count":21,"publisher":"Scientific Scholar","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n            <jats:title>Background &amp; objectives:<\/jats:title>\n            <jats:p>Studies have shown that certain flaviviruses influence susceptibility of mosquitoes by inhibiting\/enhancing replication of important flaviviruses. Hence, a study was designed to determine whether Bagaza virus (BAGV), a flavivirus isolated from <jats:italic toggle=\"yes\">Culex tritaeniorhynchus<\/jats:italic> mosquitoes in India, alters susceptibility of <jats:italic toggle=\"yes\">Cx. tritaeniorhynchus<\/jats:italic> and <jats:italic toggle=\"yes\">Cx. quinquefasciatus<\/jats:italic> mosquitoes to Japanese encephalitis (JEV) and West Nile viruses (WNV).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>JEV and WNV infection in <jats:italic toggle=\"yes\">Cx. tritaeniorhynchus<\/jats:italic> and <jats:italic toggle=\"yes\">Cx. quinquefasciatus<\/jats:italic> mosquitoes in the presence of BAGV was carried out by intrathoracic (IT) inoculation and oral feeding methods. Mosquitoes were infected with BAGV and WNV\/JEV either simultaneously or in a phased manner, in which mosquitoes were infected with BAGV by IT inoculation followed by super-infection with JEV\/WNV after eight days post-infection (PI). JEV and WNV yield on 7<jats:sup>th<\/jats:sup> and 14<jats:sup>th<\/jats:sup> day PI after super-infection was determined by 50 per cent tissue culture infective dose (TCID<jats:sub>50<\/jats:sub>) method.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>In <jats:italic toggle=\"yes\">Cx. tritaeniorhynchus<\/jats:italic> mosquitoes, prior infection with BAGV significantly reduced JEV and WNV replication while in <jats:italic toggle=\"yes\">Cx. quinquefasciatus<\/jats:italic>, BAGV influence was only seen with WNV. Reduction in virus titre was observed in IT inoculated and oral fed mosquitoes irrespective of the infection mode. JEV replication was also found reduced in <jats:italic toggle=\"yes\">Cx. tritaeniorhynchus<\/jats:italic> mosquitoes persistently infected with BAGV at passage four.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Interpretation &amp; conclusions:<\/jats:title>\n            <jats:p>BAGV infection in <jats:italic toggle=\"yes\">Cx. tritaeniorhynchus<\/jats:italic> and <jats:italic toggle=\"yes\">Cx. quinquefasciatus<\/jats:italic> mosquitoes altered their susceptibility to JEV and WNV producing low virus yield. However, the role of BAGV in inhibiting JEV\/WNV replication in field mosquitoes needs further investigations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/0971-5916.176618","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T10:34:04Z","timestamp":1455618844000},"page":"S44-S51","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Bagaza virus inhibits Japanese encephalitis &amp; West Nile virus replication in Culex tritaeniorhynchus &amp; Cx. quinquefasciatus mosquitoes"],"prefix":"10.25259","volume":"142","author":[{"given":"A.B.","family":"Sudeep","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.P.","family":"Bondre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.S.","family":"Ghodke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.V.","family":"Aher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Gokhale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"key":"R1-7-20241212","first-page":"257","article-title":"Preliminary findings of Bagaza virus (Flavivirus: Flaviviridae) growth kinetics, transmission 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