{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:23:37Z","timestamp":1761060217118,"version":"3.41.0"},"reference-count":13,"publisher":"Scientific Scholar","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,6]]},"abstract":"\n Background & objectives:<\/jats:title>\n Vascular illnesses are on the rise in India, due to increase in lifestyle diseases and demographic transition, requiring intervention to save life, organ or limbs using vascular prosthesis. The aim of this study was to develop indigenous large diameter vascular graft for treatment of patients with vascular pathologies.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n The South India Textile Research Association, at Coimbatore, Tamil Nadu, India, developed seamless woven polyester (Polyethylene terephthalate) graft at its research wing. Further characterization and testing followed by clinical trials were conducted at Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India. Fifteen in vivo<\/jats:italic> experiments were carried out in 1992-1994 in pigs as animal model. Controlled (phase I) clinical trial in ten patients was performed along with control graft. Thereafter, phase II trial involved 22 patients who underwent multi-centre clinical trial in four centres across India.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Laboratory testing showed that polyester graft was non-toxic, non-leeching and non-haemolytic with preserved long-term quality, further confirming in pigs by implanting in thoracic aorta, comparable to control Dacron grafts. Perigraft incorporation and smooth neointima formation which are prime features of excellent healing characteristics, were noted at explantation at planned intervals. Subsequently in the phase I and II clinical trials, all patients had excellent recovery without mortality or device-related adverse events. Patients receiving the test graft were followed up for 10 and 5 years, respectively. Serial clinical, duplex scans and CT angiograms performed periodically confirmed excellent graft performance.<\/jats:p>\n <\/jats:sec>\n \n Interpretation & conclusions:<\/jats:title>\n Indigenously developed Chitra vascular graft was comparable to commercially available Dacron graft, ready for clinical use at affordable cost to patients as against costly imported grafts.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0971-5916.192059","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T12:22:48Z","timestamp":1476879768000},"page":"769-781","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["The making of indigenous vascular prosthesis"],"prefix":"10.25259","volume":"143","author":[{"given":"Madathipat","family":"Unnikrishnan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidharth","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Balasubramaniam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.V.","family":"Muraleedharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur Vijayan","family":"Lal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.V.","family":"Mohanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meera","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tirur Raman","family":"Kapilamoorthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"key":"R1-14-20241212","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/00000658-195203000-00006","article-title":"The use of tubes constructed from vinyon \u201cN\u201d cloth in bridging arterial defects","volume":"135","author":"Voorhees","year":"1952","journal-title":"Ann Surg"},{"key":"R2-14-20241212","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/0741-5214(93)90120-B","article-title":"Evaluation and performance standards for arterial prostheses","volume":"17","author":"Abbott","year":"1993","journal-title":"J Vasc Surg"},{"key":"R3-14-20241212","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/0300985811402846","article-title":"Swine as models in Biomedical Research and Toxicology Testing","volume":"49","author":"Swindle","year":"2012","journal-title":"Vet Pathol"},{"key":"R4-14-20241212","first-page":"556","article-title":"A preliminary report of development of an arterial prosthesis","volume":"78","author":"Bhuvaneswar","year":"1983","journal-title":"Indian J Med Res"},{"key":"R7-14-20241212","first-page":"68","article-title":"Intra-operative blood scavenging in experimental thoracic aortic grafting in pigs using cardiotomy reservoir with a custom made low prime bubble trap","volume":"9","author":"Lal","year":"1995","journal-title":"Trends Biomater Artif Organs"},{"key":"R8-14-20241212","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/0003-4975(93)91119-8","article-title":"New modified Bentall procedure: Carrel patch and inclusion technique","volume":"55","author":"Kawazoe","year":"1993","journal-title":"Ann Thorac Surg"},{"key":"R9-14-20241212","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/ejcts\/ezt485","article-title":"Adult coarctation of the aorta repaired with a prosthetic bypass and its long-term follow-up","volume":"45","author":"Savlania","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"R11-14-20241212","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0741-5214(87)90300-4","article-title":"Mechanisms of healing in synthetic grafts","volume":"6","author":"Zacharias","year":"1987","journal-title":"J Vasc Surg"},{"key":"R12-14-20241212","first-page":"756","article-title":"The fate of Dacron vascular grafts","volume":"89","author":"DeBakey","year":"1964","journal-title":"Arch Surg"},{"key":"R13-14-20241212","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0741-5214(98)70318-0","article-title":"Anastomotic aneurysms after surgical treatment of Takayasu's arteritis: a 40-year experience","volume":"27","author":"Miyata","year":"1998","journal-title":"J Vasc Surg"},{"key":"R15-14-20241212","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/00015458.2005.11679712","article-title":"Intrinsic structural failure of polyester (Dacron) vascular grafts. 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