{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:08:01Z","timestamp":1785326881935,"version":"3.55.0"},"reference-count":37,"publisher":"Scientific Scholar","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Pancreatic cancer has one of the worst prognoses among all types of cancers. The survival rate is less than 5 per cent; this is due to difficulty in diagnosing at an early stage. Despite the improvements in diagnostic imaging techniques such as computed tomography, magnetic resonance imaging, <jats:italic toggle=\"yes\">etc<\/jats:italic>., the early diagnosis of pancreatic cancer is still difficult. Alternative methods of diagnosing pancreatic cancer at an early stage are presently been explored. The detection of telomerase activity has been proposed to be a useful tool in the diagnosis of pancreatic cancer. Telomerase is made up of three major parts namely, human telomerase reverse transcriptase, human telomerase and telomerase -associated protein. Several researchers have shown telomerase activity in tissues and fluids of patients with pancreatic and other types of cancers. About 95 per cent telomerase activity has been detected in pancreatic adenocarcinoma. Since telomerase activity is present in a vast majority of human cancers, it might have a role in the diagnosis and treatment of cancer.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/0971-5916.93420","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T21:54:59Z","timestamp":1330984499000},"page":"26-30","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Expression of telomerase &amp; its significance in the diagnosis of pancreatic cancer"],"prefix":"10.25259","volume":"135","author":[{"given":"Anutebeh Verdo","family":"Zisuh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Quan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-Dao","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"R1-7-20241212","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/sj.bjc.6604568","article-title":"Modelling prognostic factor in advanced pancreatic cancer","volume":"99","author":"Stocken","year":"2008","journal-title":"Br J Cancer"},{"key":"R3-7-20241212","first-page":"236","article-title":"In situ telomerase activity in pancreatic juice may discriminate pancreatic from other pancreatic diseases","volume":"36","author":"Uehara","year":"2008","journal-title":"Gastrointestinal Oncol"},{"key":"R4-7-20241212","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1593\/neo.08578","article-title":"Prognostic relevance of hTERT mRNA expression in ductal adenocarcinoma of the pancreas","volume":"10","author":"Grochola","year":"2008","journal-title":"Neoplasia"},{"key":"R5-7-20241212","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev.genet.34.1.331","article-title":"Telomeres and their control","volume":"34","author":"McEachern","year":"2000","journal-title":"Annu Rev Genet"},{"key":"R6-7-20241212","doi-asserted-by":"crossref","first-page":"10857","DOI":"10.1128\/MCB.24.24.10857-10867.2004","article-title":"Counting of Rif1P and Rif2P on saccharomyces cerevisiae telomere regulates telomere length","volume":"24","author":"Levy","year":"2004","journal-title":"Mol Cell Bio"},{"key":"R7-7-20241212","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1126\/science.1185100","article-title":"Loss of Rapi induces telomere recombination in the absent of NHEj or a DNA damage signal","volume":"327","author":"Sfeir","year":"2010","journal-title":"Science"},{"key":"R8-7-20241212","first-page":"141","article-title":"Telomere acquire embryonic stem cell characteristics induced pluripotent stem cells","volume":"4","author":"Marion","year":"2009","journal-title":"Stem cells"},{"key":"R9-7-20241212","doi-asserted-by":"crossref","first-page":"14191","DOI":"10.1021\/bi050628s","article-title":"Telomerase as a DNA-dependent DNA polymerase","volume":"44","author":"Legassie","year":"2005","journal-title":"Biochemistry"},{"key":"R10-7-20241212","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/nar\/gkh546","article-title":"Human telomerase catalyzes nucleolytic primer cleavage","volume":"32","author":"Huard","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"R11-7-20241212","doi-asserted-by":"crossref","first-page":"14276","DOI":"10.1073\/pnas.96.25.14276","article-title":"Inhibition of telomerase lead to eroded telomere reduced proliferation and cell death","volume":"96","author":"Herbert","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"R12-7-20241212","first-page":"290","article-title":"Expression of telomerase activity, telomerase RNA component and telomerase catalytic subunit gene in lung cancer","volume":"115","author":"Chen","year":"2002","journal-title":"Chin Med J (Engl"},{"key":"R13-7-20241212","first-page":"287","article-title":"hTR RNA component as a marker of cellular proliferation in oral lichen planus","volume":"9","author":"Flatharta","year":"2008","journal-title":"Asian Pac J Cancer Prev"},{"key":"R14-7-20241212","doi-asserted-by":"crossref","first-page":"718","DOI":"10.4161\/cc.5.7.2636","article-title":"Role of the TRF2 telomeric protein in cancer and ageing","volume":"5","author":"Mu\u00f1oz","year":"2006","journal-title":"Cell Cycle"},{"key":"R15-7-20241212","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0092-8674(00)80538-3","article-title":"The putative human telomerase catalytic subunit gene is upregulated in tumor cells and during immortalisation","volume":"90","author":"Meyerson","year":"1997","journal-title":"Cell"},{"key":"R16-7-20241212","first-page":"2518","article-title":"Structure and variability of human chromosome ends","volume":"10","author":"De","year":"1990","journal-title":"Mol Cell Biol"},{"key":"R17-7-20241212","first-page":"221","article-title":"Imetelstat (GRN163) Telomerase-based cancer therapy","volume":"184","author":"Roth","year":"2010","journal-title":"Cancer Res"},{"key":"R18-7-20241212","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1158\/1078-0432.CCR-09-2850","article-title":"The telomerase antagonist imetelstat efficiently target glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth","volume":"1","author":"Marian","year":"2010","journal-title":"Clin Cancers Res"},{"key":"R19-7-20241212","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1158\/1078-0432.CCR-04-1581","article-title":"Quantitative assessment of telomerase activity and human telomerase reverse transcriptase messenger RNA levels in pancreatic juice samples for the diagnosis of pancreatic cancer","volume":"11","author":"Ohuchida","year":"2005","journal-title":"Clin Cancer Res"},{"key":"R20-7-20241212","first-page":"326","article-title":"Telomerase activity is detected in pancreatic cancer but not in benign tumors","volume":"57","author":"Hiyama","year":"1997","journal-title":"Cancer Res"},{"key":"R21-7-20241212","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"key":"R22-7-20241212","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/nbt.1587","article-title":"DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity","volume":"27","author":"Henson","year":"2009","journal-title":"Nat Biotechnol"},{"key":"R23-7-20241212","first-page":"1976","article-title":"Diagnosis of pancreatic adenocarcinoma by detection of human telomerase reverse transcriptase messenger RNA in pancreatic juice with sample quantification","volume":"7","author":"Seki","year":"2001","journal-title":"Clin Cancer Res"},{"key":"R24-7-20241212","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/1097-0142(20010101)91:1<35::AID-CNCR5>3.0.CO;2-A","article-title":"Preoperative diagnosis of intraductal mucinous tumors of the pancreas with attention to telomerase activity","volume":"91","author":"Inoue","year":"2001","journal-title":"Cancer"},{"key":"R25-7-20241212","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1111\/j.1572-0241.1998.00557.x","article-title":"Telomerase activity detected in pancreatic juice 19 months before a tumor is detected in a patient of with pancreatic cancer","volume":"93","author":"Suehara","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"R26-7-20241212","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1093\/carcin\/18.11.2085","article-title":"Mortalised mouse mammary cells in vivo do not exhibit increase telomerase activity","volume":"18","author":"Jiang","year":"1997","journal-title":"Carcinogenesis"},{"key":"R27-7-20241212","first-page":"326","article-title":"Telomerase activity is detected in pancreatic cancer but not in benign tumors","volume":"57","author":"Hiyama","year":"1997","journal-title":"Cancer Res"},{"key":"R28-7-20241212","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/MPA.0b013e3181a16d28","article-title":"Usefulness of human telomerase reverse transcriptase in pancreatic juice as a biomaker of pancreatic malignancy","volume":"38","author":"Nakashima","year":"2009","journal-title":"Pancreas"},{"key":"R29-7-20241212","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.surg.2007.07.042","article-title":"Detection of human telomerase reverse transcriptase (hTERT) expression in tissue and pancreatic juice from pancreatic cancer","volume":"143","author":"Hashimoto","year":"2008","journal-title":"Surgery"},{"key":"R30-7-20241212","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1245\/s10434-009-0333-8","article-title":"Positive regulation of human telomerase reverse transcriptase gene expression and telomerase activity by DNA methylation in pancreatic cancer","volume":"16","author":"Kumari","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"R31-7-20241212","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s005340200003","article-title":"Genetic diagnosis of pancreatic cancer","volume":"9","author":"Mizumoto","year":"2002","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"R32-7-20241212","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00981880","article-title":"Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol","volume":"17","author":"Piatyszek","year":"1995","journal-title":"Method Cell Sci"},{"key":"R33-7-20241212","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0304-3835(02)00709-7","article-title":"Telomerase as tumor marker","volume":"194","author":"Hiyama","year":"2003","journal-title":"Cancer Lett"},{"key":"R34-7-20241212","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/bjc.1997.90","article-title":"Telomerase activity in normal and malignant mammalian tissues: feasibility of telomerase as a taget for cancer chemotherapy","volume":"75","author":"Burger","year":"1997","journal-title":"Br J Cancer"},{"key":"R35-7-20241212","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/1097-0142(20000825)90:4<235::AID-CNCR6>3.0.CO;2-Z","article-title":"Telomerase activity as a marker of breast cancinoma in fine-needle aspirated samples","volume":"90","author":"Hiyama","year":"2000","journal-title":"Cancer"},{"key":"R36-7-20241212","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/(SICI)1097-0215(19980220)79:1<8::AID-IJC2>3.0.CO;2-5","article-title":"Telomerase activity correlates with tumor aggressiveness and reflects therapy effect in breast cancer","volume":"79","author":"Hoos","year":"1998","journal-title":"Int J Cancer"},{"key":"R37-7-20241212","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.3748\/wjg.v12.i25.4004","article-title":"Inhibitory effects of antisense phosphorothioate oligodeoxynucleotides on pancreatic cancer cell Bxpc-3 telomerase activity and cell growth in vitro","volume":"12","author":"Wang","year":"2006","journal-title":"World J Gastroenterol"},{"key":"R38-7-20241212","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s005340200036","article-title":"Telomerase as a new target for pancreatic cancer treatment","volume":"9","author":"Sato","year":"2002","journal-title":"J Hepatobiliary Pancreat Surg"}],"container-title":["Indian Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/02223309-201235010-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T22:55:28Z","timestamp":1751496928000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijmr.org.in\/expression-of-telomerase-its-significance-in-the-diagnosis-of-pancreatic-cancer\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.4103\/0971-5916.93420","relation":{},"ISSN":["0971-5916"],"issn-type":[{"value":"0971-5916","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}