{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:52:47Z","timestamp":1793332367342,"version":"4.5.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Indian Soc Periodontol"],"published-print":{"date-parts":[[2015]]},"DOI":"10.4103\/0972-124x.157879","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T06:06:25Z","timestamp":1432879585000},"page":"381","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of the effect of nicotine and metabolites on the periodontal status and the mRNA expression of interleukin-1\u03b2 in smokers with chronic periodontitis"],"prefix":"10.4103","volume":"19","author":[{"given":"Ajita","family":"Meenawat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Govila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Punn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RameshwarShantaram","family":"Dolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0972-124X.157879-1","first-page":"9","volume-title":"The pathogenesis of human periodontitis: An introduction","author":"Page","year":"2000","journal-title":"Periodontol"},{"key":"key-10.4103\/0972-124X.157879-2","first-page":"1827","volume-title":"Chemokine expression in human oral keratinocyte cell lines and keratinized mucosa","author":"Bickel","year":"1996","journal-title":"J Dent Res"},{"key":"key-10.4103\/0972-124X.157879-3","first-page":"247","volume-title":"Interleukin-1beta, clinical parameters and matched cellular-histopathologic changes of biopsied gingival tissue from periodontitis patients","author":"Hou","year":"2003","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0972-124X.157879-4","first-page":"153","volume-title":"Bioassay of interleukin 1 (IL-1) in human gingival crevicular fluid during experimental gingivitis","author":"Kinane","year":"1992","journal-title":"Arch Oral Biol"},{"key":"key-10.4103\/0972-124X.157879-5","first-page":"21830","volume-title":"Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control","author":"Bouaboula","year":"1992","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0972-124X.157879-6","unstructured":"Tobacco use and the periodontal patient. J Periodontol 1996;67:51-6."},{"key":"key-10.4103\/0972-124X.157879-7","first-page":"107","volume-title":"Tobacco smoking and risk of periodontal disease","author":"Bregstrom","year":"2003","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0972-124X.157879-8","doi-asserted-by":"crossref","unstructured":"Grossi SG, Zambon JJ, Ho AW, Koch G, Dunford RG, Machtei EE, et al. Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. J Periodontol 1994;65:260-7.","DOI":"10.1902\/jop.1994.65.3.260"},{"key":"key-10.4103\/0972-124X.157879-9","first-page":"51","volume-title":"Gingival crevicular fluid immunoglobulins in smokers with chronic periodontitis","author":"Sukumaran","year":"2008","journal-title":"Pak Oral Dent J"},{"key":"key-10.4103\/0972-124X.157879-10","doi-asserted-by":"crossref","unstructured":"Grossi SG, Genco RJ, Machtei EE, Ho AW, Koch G, Dunford R, et al. Assessment of risk for periodontal disease. II. Risk indicators for alveolar bone loss. J Periodontol 1995;66:23-9.","DOI":"10.1902\/jop.1995.66.1.23"},{"key":"key-10.4103\/0972-124X.157879-11","first-page":"212","volume-title":"Smoking and subgingival microflora in periodontal disease","author":"Bostr\u00f6m","year":"2001","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0972-124X.157879-12","first-page":"38","volume-title":"Consensus report: Chronic periodontitis","author":"Lindhe","year":"1999","journal-title":"Ann Periodontol"},{"key":"key-10.4103\/0972-124X.157879-13","first-page":"252","volume-title":"Candidate salivary biomarkers associated with alveolar bone loss: Cross-sectional and in vitro studies","author":"Ng","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"key":"key-10.4103\/0972-124X.157879-14","first-page":"346","volume-title":"Correlation between salivary IL-1beta levels and periodontal clinical status","author":"Tob\u00f3n-Arroyave","year":"2008","journal-title":"Arch Oral Biol"},{"key":"key-10.4103\/0972-124X.157879-15","first-page":"166","volume-title":"Relevance of local Th2-type cytokine mRNA expression in immunocompetent infiltrates in inflamed gingival tissue to periodontal diseases","author":"Tokoro","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"key-10.4103\/0972-124X.157879-16","doi-asserted-by":"crossref","unstructured":"Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533-51.","DOI":"10.3109\/00016356309011240"},{"key":"key-10.4103\/0972-124X.157879-17","doi-asserted-by":"crossref","unstructured":"Silness J, Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion. Acta Odontol Scand 1964;22:121-35.","DOI":"10.3109\/00016356408993968"},{"key":"key-10.4103\/0972-124X.157879-18","unstructured":"U.S. Department of Health and Human Services NCIHS. NHANES III Reference Manuals and Reports. Hyattsville, MD: Centers for Disease Control and Prevention; 2004."},{"key":"key-10.4103\/0972-124X.157879-19","first-page":"156","volume-title":"Measurement of interleukin-1 alpha and-1 beta in gingival crevicular fluid: Implications for the pathogenesis of periodontal disease","author":"Masada","year":"1990","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0972-124X.157879-20","first-page":"1225","volume-title":"Association between cigarette smoking, bacterial pathogens, and periodontal status","author":"Stoltenberg","year":"1993","journal-title":"J Periodontol"},{"key":"key-10.4103\/0972-124X.157879-21","first-page":"316","volume-title":"Incidence of attachment loss in community-dwelling older adults","author":"Brown","year":"1994","journal-title":"J Periodontol"},{"key":"key-10.4103\/0972-124X.157879-22","first-page":"16","volume-title":"Evidence for cigarette smoking as a major risk factor for periodontitis","author":"Haber","year":"1993","journal-title":"J Periodontol"},{"key":"key-10.4103\/0972-124X.157879-23","first-page":"297","volume-title":"Risk indicators for periodontitis in a military treatment population","author":"Horning","year":"1992","journal-title":"J Periodontol"},{"key":"key-10.4103\/0972-124X.157879-24","first-page":"398","volume-title":"Smoking-attributable periodontal disease in the Australian adult population","author":"Do","year":"2008","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0972-124X.157879-25","first-page":"1050","volume-title":"Cigarette smoking increases the risk for subgingival infection with periodontal pathogens","author":"Zambon","year":"1996","journal-title":"J Periodontol"},{"key":"key-10.4103\/0972-124X.157879-26","first-page":"324","volume-title":"The effect of SRP on the clinical and microbiological parameters of periodontal diseases","author":"Haffajee","year":"1997","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0972-124X.157879-27","first-page":"25","volume-title":"Clinical and microbiological characteristics of smokers with early onset periodontitis","author":"Kamma","year":"1999","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0972-124X.157879-28","first-page":"680","volume-title":"Tobacco smoking and periodontal hemorrhagic responsiveness","author":"Bergstr\u00f6m","year":"2001","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0972-124X.157879-29","first-page":"441","volume-title":"A validated high performance liquid chromatographic method for analysis of nicotine in pure form and from formulations","author":"Tambwekar","year":"2003","journal-title":"J Pharm Biomed Anal"},{"key":"key-10.4103\/0972-124X.157879-30","first-page":"76","volume-title":"Alterations of neutrophil oxidative burst by in vitro smoke exposure: Implications for oral and systemic diseases","author":"Ryder","year":"1998","journal-title":"Ann Periodontol"},{"key":"key-10.4103\/0972-124X.157879-31","first-page":"15","volume-title":"The relative buffering capacities of saliva and moist snuff: Implications for nicotine absorption","author":"Ciolino","year":"2001","journal-title":"J Anal Toxicol"},{"key":"key-10.4103\/0972-124X.157879-32","first-page":"447","volume-title":"Prostaglandin E2 and interleukin-1 concentrations in nicotine-exposed oral keratinocyte cultures","author":"Johnson","year":"1997","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0972-124X.157879-33","first-page":"1318","volume-title":"Immunohistochemical study of vestibular gingival blood vessel density and internal circumference in smokers and non-smokers","author":"Mirbod","year":"2001","journal-title":"J Periodontol"},{"key":"key-10.4103\/0972-124X.157879-34","first-page":"387","volume-title":"Biomarkers of tobacco exposure or harm: Application to clinical and epidemiological studies 25-26 October 2001, Minneapolis, Minnesota","author":"Hatsukami","year":"2003","journal-title":"Nicotine Tob Res"},{"key":"key-10.4103\/0972-124X.157879-35","first-page":"880","volume-title":"Specific detection of anabasine, nicotine, and nicotine metabolites in urine by liquid chromatography-tandem mass spectrometry","author":"Hoofnagle","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"key-10.4103\/0972-124X.157879-36","first-page":"158","volume-title":"Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1beta in gingival crevicular fluid and gingival tissues","author":"Yoshinari","year":"2004","journal-title":"J Periodontal Res"}],"container-title":["Journal of Indian Society of Periodontology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:32:11Z","timestamp":1786649531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0972-124X.157879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"alternative-id":["157879"],"URL":"https:\/\/doi.org\/10.4103\/0972-124x.157879","relation":{},"ISSN":["0972-124X"],"issn-type":[{"value":"0972-124X","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}