{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:16:54Z","timestamp":1790090214806,"version":"4.0.1"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Erdheim Chester disease (ECD) is a rare non-Langerhans cell histiocytosis, commonly involving the musculoskeletal system. Other tissue can also be involved, including the central nervous system with wide spectrum of clinical features, at times being nonspecific. This can cause diagnostic dilemmas with delay in diagnosis and initiation of therapy. Here we describe a 63-year-old man who had presented with ataxia and behavioral changes, bony pains, weight loss, and fatigue. His computed tomography (CT), 99Tc scintigraphy and histopathological features on bone biopsy were consistent with ECD. Thus, ECD should be considered as a differential diagnosis in patients presenting with bony pain and nonspecific features of multiorgan involvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0972-2327.157181","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T03:16:06Z","timestamp":1432005366000},"page":"338-341","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["A case of Erdheim Chester disease with central nervous system involvement"],"prefix":"10.4103","volume":"18","author":[{"given":"Anil Kumar","family":"Patil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Muthusamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjith","family":"Aaron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanda","family":"Kachare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunithi","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhakar","family":"Sniya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20260109","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00005792-199605000-00005","article-title":"Erdheim-Chester disease. 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Cardiac involvement in Erdheim-Chester disease: Magnetic resonance and computed tomographic scan imaging in a monocentric series of 37 patients","volume":"119","author":"Haroche","year":"2009","journal-title":"Circulation"},{"key":"R11-15-20260109","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1002\/art.27672","article-title":"Pulmonary involvement in Erdheim-Chester disease: A single-center study of thirty-four patients and a review of the literature","volume":"62","author":"Arnaud","year":"2010","journal-title":"Arthritis Rheum"},{"key":"R12-15-20260109","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1182\/blood-2012-05-430140","article-title":"High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses","volume":"120","author":"Haroche","year":"2012","journal-title":"Blood"},{"key":"R13-15-20260109","doi-asserted-by":"crossref","first-page":"e331","DOI":"10.1200\/JCO.2012.43.2260","article-title":"Erdheim-Chester disease harboring the BRAF V600E mutation","volume":"30","author":"Blombery","year":"2012","journal-title":"J Clin Oncol"},{"key":"R14-15-20260109","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1182\/blood-2012-07-446286","article-title":"Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation","volume":"121","author":"Haroche","year":"2013","journal-title":"Blood"},{"key":"R15-15-20260109","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1517\/21678707.2013.847785","article-title":"Strategies and treatment alternatives in the management of Erdheim \u2014 Chester disease","volume":"1","author":"Mazor","year":"2013","journal-title":"Expert Opin Orphan Drugs"},{"key":"R16-15-20260109","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1182\/blood-2010-06-294108","article-title":"CNS involvement and treatment with interferonalpha are independent prognostic factors in Erdheim-Chester disease: A multicenter survival analysis of 53 patients","volume":"117","author":"Arnaud","year":"2011","journal-title":"Blood"}],"container-title":["Annals of Indian Academy of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223306-201518030-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:04:12Z","timestamp":1786647852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223306-201518030-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0972-2327.157181","relation":{},"ISSN":["0972-2327"],"issn-type":[{"value":"0972-2327","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}