{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:58Z","timestamp":1786649938038,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In India, the correlates of leukoaraiosis (LA) have not been widely reported. This study was designed to investigate the factors which correlate with LA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We included patients with LA who consented for the study and graded their severity on the basis of Fazekas scale. We excluded patients with LA who did not consent\/cooperate for the study as also patients with other white matter changes which mimic LA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>LA is a common and under-rated cause of disability. Presentations include cognitive decline, gait disturbance, dysarthria, bladder\/bowel sphincter disturbances, and increased risk of stroke. The comorbidities include hyperhomocysteinemia, hypertension, dyslipidemia, tobacco use, ischemic heart disease, previous stroke, atrial fibrillation, chronic renal failure, and bariatric surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0972-2327.194425","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T07:27:21Z","timestamp":1479713241000},"page":"478-481","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Clinical correlates of leukoaraiosis"],"prefix":"10.4103","volume":"19","author":[{"given":"Rustom S.","family":"Wadia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandesh K.","family":"Ghiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshita","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh M.","family":"Sontakke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwas","family":"Bharadwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul V.","family":"Sonawane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh P.","family":"Bade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Shrikanth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Goli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit Singh","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh A.","family":"Nadkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20260108","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1212\/WNL.32.8.871","article-title":"Lacunar strokes and infarcts: A review","volume":"32","author":"Fisher","year":"1982","journal-title":"Neurology"},{"key":"R2-10-20260108","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1001\/archneur.1987.00520130013009","article-title":"Leuko-araiosis","volume":"44","author":"Hachinski","year":"1987","journal-title":"Arch Neurol"},{"key":"R3-10-20260108","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1212\/WNL.44.7.1246","article-title":"Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: The Rotterdam Study","volume":"44","author":"Breteler","year":"1994","journal-title":"Neurology"},{"key":"R4-10-20260108","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1001\/archneur.1987.00520130024012","article-title":"Cognitive and neurologic findings in subjects with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis)","volume":"44","author":"Steingart","year":"1987","journal-title":"Arch Neurol"},{"key":"R5-10-20260108","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1136\/jnnp.60.4.431","article-title":"Clinical features of leuko-araiosis","volume":"60","author":"Tarvonen-Schr\u00f6der","year":"1996","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R6-10-20260108","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging","volume":"149","author":"Fazekas","year":"1987","journal-title":"AJR Am J Roentgenol"},{"key":"R7-10-20260108","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1161\/01.STR.19.9.1083","article-title":"The Lausanne Stroke Registry: Analysis of 1,000 consecutive patients with first stroke","volume":"19","author":"Bogousslavsky","year":"1988","journal-title":"Stroke"},{"key":"R8-10-20260108","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/jnnp.72.2.211","article-title":"Incidence and case fatality rates of stroke subtypes in a multiethnic population: The South London Stroke Register","volume":"72","author":"Wolfe","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R9-10-20260108","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/hs1201.100209","article-title":"Epidemiology of ischemic stroke subtypes according to TOAST criteria: Incidence, recurrence, and long-term survival in ischemic stroke subtypes: A population-based study","volume":"32","author":"Kolominsky-Rabas","year":"2001","journal-title":"Stroke"},{"key":"R10-10-20260108","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1161\/01.STR.26.7.1293","article-title":"The significance of cerebral white matter abnormalities 100 years after Binswanger's report. 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